TRPV5

TRPV5: an ingeniously controlled calcium channel.
[18596722] Kidney Int 74(10): 1241-6 (2008)

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.
[15747113] Naunyn Schmiedebergs Arch Pharmacol 371(4): 295-306 (2005)

The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation.
[12765695] Cell Calcium 33(5-6): 497-507 (2003)

Vanilloid transient receptor potential cation channels: an overview.
[18220815] Curr Pharm Des 14(1): 18-31 (2008)

Calciotropic and magnesiotropic TRP channels.
[18268363] Physiology (Bethesda) 23(): 32-40 (2008)

Epithelial calcium channels: from identification to function and regulation.
[12684797] Pflugers Arch 446(3): 304-8 (2003)

(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6.
[12748856] Pflugers Arch 446(4): 401-9 (2003)

The epithelial calcium channel, ECaC1: molecular details of a novel player in renal calcium handling.
[11427620] Nephrol Dial Transplant 16(7): 1329-35 (2001)

Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2.
[11744752] J Physiol 537(Pt 3): 747-61 (2001)

Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.
[16148038] J Am Soc Nephrol 16(11): 3188-95 (2005)

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.
[14679186] J Clin Invest 112(12): 1906-14 (2003)

Gene structure and chromosomal mapping of human epithelial calcium channel.
[10944439] Biochem Biophys Res Commun 275(1): 47-52 (2000)

Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1).
[10945469] Genomics 67(1): 48-53 (2000)

Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia.
[10085067] J Biol Chem 274(13): 8375-8 (1999)

Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC.
[10970426] J Physiol 527 Pt 2(): 239-48 (2000)

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.
[12574114] EMBO J 22(4): 776-85 (2003)

Homo- and heteromeric assembly of TRPV channel subunits.
[15713749] J Cell Sci 118(Pt 5): 917-28 (2005)

Molecular determinants in TRPV5 channel assembly.
[15489237] J Biol Chem 279(52): 54304-11 (2004)

Functional properties of the epithelial Ca2+ channel, ECaC.
[11765215] Gen Physiol Biophys 20(3): 239-53 (2001)

Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.
[14630907] J Biol Chem 279(8): 6853-62 (2004)

Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium.
[17942632] Am J Physiol Cell Physiol 293(6): C1962-70 (2007)

TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.
[16044309] Pflugers Arch 451(1): 181-92 (2005)

Permeation and gating properties of the novel epithelial Ca(2+) channel.
[10660551] J Biol Chem 275(6): 3963-9 (2000)

Conformational changes of pore helix coupled to gating of TRPV5 by protons.
[16121193] EMBO J 24(18): 3224-34 (2005)

Modulation of the epithelial Ca2+ channel ECaC by extracellular pH.
[11417220] Pflugers Arch 442(2): 237-42 (2001)

Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH.
[14525991] J Biol Chem 278(51): 51044-52 (2003)

On the role of pore helix in regulation of TRPV5 by extracellular protons.
[17334836] J Membr Biol 212(3): 191-8 (2006)

Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels.
[17178838] Mol Cell Biol 27(4): 1486-94 (2007)

Regulation of TRPV5 single-channel activity by intracellular pH.
[18004496] J Membr Biol 220(1-3): 79-85 (2007)

The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium.
[10425212] Biochem Biophys Res Commun 261(2): 488-92 (1999)

The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel.
[11035011] J Biol Chem 276(2): 1020-5 (2001)

Modulation of the epithelial calcium channel, ECaC, by intracellular Ca2+.
[11352507] Cell Calcium 29(6): 417-28 (2001)

80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).
[15100231] J Biol Chem 279(25): 26351-7 (2004)

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
[22354706] J Struct Funct Genomics 13(2): 91-100 (2012)

Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone.
[21576356] Mol Cell Biol 31(14): 2845-53 (2011)

The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5.
[16352746] Am J Physiol Renal Physiol 290(5): F1253-9 (2006)

PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+.
[16230466] J Gen Physiol 126(5): 439-51 (2005)

Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.
[12077127] J Biol Chem 277(34): 30852-8 (2002)

Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.
[17233615] Biochem Soc Trans 35(Pt 1): 115-9 (2007)

Regulation of TRPV5 and TRPV6 by associated proteins.
[16682485] Am J Physiol Renal Physiol 290(6): F1295-302 (2006)

Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.
[12660155] EMBO J 22(7): 1478-87 (2003)

Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.
[16380433] J Am Soc Nephrol 17(1): 26-30 (2006)

Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner.
[21952826] Cell Mol Life Sci 69(6): 981-92 (2012)

TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
[18077461] J Biol Chem 283(7): 4077-86 (2008)

Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.
[16354700] Mol Cell Biol 26(1): 303-12 (2006)

Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5.
[18305097] Am J Physiol Renal Physiol 294(5): F1212-21 (2008)

The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization.
[20628046] J Biol Chem 285(37): 28481-7 (2010)

WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C.
[20061383] J Biol Chem 285(9): 6604-11 (2010)

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.
[18768590] Am J Physiol Renal Physiol 295(5): F1472-84 (2008)

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane.
[18703016] Biochem Biophys Res Commun 375(2): 225-9 (2008)

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
[17018846] Am J Physiol Renal Physiol 292(2): F545-54 (2007)

Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
[21187068] Biochem Biophys Res Commun 404(4): 979-84 (2011)

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.
[16565876] Pflugers Arch 452(4): 407-17 (2006)

Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1.
[15665527] Cell Physiol Biochem 15(1-4): 175-82 (2005)

Significance of SGK1 in the regulation of neuronal function.
[20530112] J Physiol 588(Pt 18): 3349-54 (2010)

Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3.
[18005662] FEBS Lett 581(29): 5586-90 (2007)

Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
[17006539] EMBO J 25(20): 4707-16 (2006)

Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking.
[21795703] J Biol Chem 286(37): 32132-9 (2011)

Regulation of the epithelial calcium channel TRPV5 by extracellular factors.
[17565273] Curr Opin Nephrol Hypertens 16(4): 319-24 (2007)

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.
[18606998] Proc Natl Acad Sci U S A 105(28): 9805-10 (2008)

The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.
[18495742] Nephrol Dial Transplant 23(11): 3397-402 (2008)

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
[16239475] Science 310(5747): 490-3 (2005)

Regulation of ion channels by secreted Klotho.
[22396165] Adv Exp Med Biol 728(): 100-6 (2012)

Klotho prevents renal calcium loss.
[19713312] J Am Soc Nephrol 20(11): 2371-9 (2009)

Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism.
[16775459] Curr Opin Nephrol Hypertens 15(4): 437-41 (2006)

Activation of the Ca2+-sensing receptor stimulates the activity of the epithelial Ca2+ channel TRPV5.
[19157541] Cell Calcium 45(4): 331-9 (2009)

Role of the calcium-sensing receptor in reducing the risk for calcium stones.
[21784822] Clin J Am Soc Nephrol 6(8): 2076-82 (2011)

Hypercalcemia reduces plasma renin via parathyroid hormone, renal interstitial calcium, and the calcium-sensing receptor.
[21825222] Hypertension 58(4): 604-10 (2011)

Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation.
[19423690] J Am Soc Nephrol 20(8): 1693-704 (2009)

Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone.
[16164647] Kidney Int 68(4): 1708-21 (2005)

Molecular Mechanisms of Vitamin D Action.
[22782502] Calcif Tissue Int (): (2012)

Calcitriol controls the epithelial calcium channel in kidney.
[11423563] J Am Soc Nephrol 12(7): 1342-9 (2001)

Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.
[15225790] J Steroid Biochem Mol Biol 89-90(1-5): 303-8 (2004)

Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
[18287084] Proc Natl Acad Sci U S A 105(7): 2598-603 (2008)

Rapid effects of 17beta-estradiol on TRPV5 epithelial Ca2+ channels in rat renal cells.
[19463684] Steroids 74(8): 642-9 (2009)

1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney.
[12138142] J Am Soc Nephrol 13(8): 2102-9 (2002)

Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins.
[20090667] Kidney Int 77(7): 601-8 (2010)

Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia.
[14978156] J Am Soc Nephrol 15(3): 549-57 (2004)

Effects of cyclosporine, tacrolimus and rapamycin on renal calcium transport and vitamin D metabolism.
[21691056] Am J Nephrol 34(1): 87-94 (2011)

Pharmacology of vanilloid transient receptor potential cation channels.
[19297520] Mol Pharmacol 75(6): 1262-79 (2009)

Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.
[11588099] Br J Pharmacol 134(3): 453-62 (2001)

Inhibition of bone resorption by econazole in rat osteoclast-like cells through suppressing TRPV5.
[21725822] Arch Pharm Res 34(6): 1007-13 (2011)

Toward a comprehensive molecular model of active calcium reabsorption.
[10710538] Am J Physiol Renal Physiol 278(3): F352-60 (2000)

Mechanisms and regulation of epithelial Ca2+ absorption in health and disease.
[17850211] Annu Rev Physiol 70(): 257-71 (2008)

Calcium absorption across epithelia.
[15618484] Physiol Rev 85(1): 373-422 (2005)

Epithelial Ca2+ and Mg2+ channels in health and disease.
[15574510] J Am Soc Nephrol 16(1): 15-26 (2005)

Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.
[12869611] J Physiol 551(Pt 3): 729-40 (2003)

ECaC: the gatekeeper of transepithelial Ca2+ transport.
[12445453] Biochim Biophys Acta 1600(1-2): 6-11 (2002)

TRPV5, the gateway to Ca2+ homeostasis.
[17217059] Handb Exp Pharmacol (179): 207-20 (2007)

Trpv5/6 is vital for epithelial calcium uptake and bone formation.
[21670068] FASEB J 25(9): 3197-207 (2011)

Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
[17005931] J Am Soc Nephrol 17(11): 3020-7 (2006)

Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.
[16763551] EMBO J 25(13): 2978-88 (2006)

Mechanisms of renal calcium transport.
[11014931] Exp Nephrol 8(6): 343-50 (2000)

The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport.
[20969972] Int J Biochem Cell Biol 43(1): 1-4 (2011)

Molecular mechanism of active Ca2+ reabsorption in the distal nephron.
[11826278] Annu Rev Physiol 64(): 529-49 (2002)

Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron.
[11704552] Am J Physiol Renal Physiol 281(6): F1021-7 (2001)

Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney.
[14569082] J Am Soc Nephrol 14(11): 2731-40 (2003)

A rat kidney-specific calcium transporter in the distal nephron.
[10875938] J Biol Chem 275(36): 28186-94 (2000)

Localization of the epithelial Ca(2+) channel in rabbit kidney and intestine.
[10864572] J Am Soc Nephrol 11(7): 1171-8 (2000)

Mechanism of urinary calcium regulation by urinary magnesium and pH.
[18448585] J Am Soc Nephrol 19(8): 1530-7 (2008)

Acid-base status determines the renal expression of Ca2+ and Mg2+ transport proteins.
[16421227] J Am Soc Nephrol 17(3): 617-26 (2006)

TRP channels in kidney disease.
[17346947] Biochim Biophys Acta 1772(8): 928-36 (2007)

Effects of furosemide on renal calcium handling.
[17652376] Am J Physiol Renal Physiol 293(4): F1231-7 (2007)

Effect of thiazide on renal gene expression of apical calcium channels and calbindins.
[15265769] Am J Physiol Renal Physiol 287(6): F1164-70 (2004)

Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney.
[12846750] Kidney Int 64(2): 555-64 (2003)

Renal adaptation to gentamicin-induced mineral loss.
[22378246] Am J Nephrol 35(3): 279-86 (2012)

The expression and implication of TRPV5, Calbindin-D28k and NCX1 in idiopathic hypercalciuria.
[18846343] J Huazhong Univ Sci Technolog Med Sci 28(5): 580-3 (2008)

Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome.
[20848653] Hum Mutat 31(12): 1304-15 (2010)

Deletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting.
[21873623] Nephrol Dial Transplant 27(4): 1368-79 (2012)

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.
[20147368] Am J Physiol Renal Physiol 298(5): F1152-61 (2010)

Renal Ca2+ handling in sgk1 knockout mice.
[16685564] Pflugers Arch 452(4): 444-52 (2006)

Characterization of a murine renal distal convoluted tubule cell line for the study of transcellular calcium transport.
[14625201] Am J Physiol Renal Physiol 286(3): F483-9 (2004)

Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D(3)-enhanced duodenal calcium transport in male mice.
[22275752] Am J Physiol Endocrinol Metab 302(8): E903-13 (2012)

The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.
[16291808] Proc Natl Acad Sci U S A 102(48): 17507-12 (2005)

TRPV-5 mediates a receptor activator of NF-kappaB (RANK) ligand-induced increase in cytosolic Ca2+ in human osteoclasts and down-regulates bone resorption.
[20547482] J Biol Chem 285(33): 25354-62 (2010)

The role of the membrane potential in chondrocyte volume regulation.
[21328349] J Cell Physiol 226(11): 2979-86 (2011)

Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.
[17299139] Am J Physiol Renal Physiol 292(5): F1345-53 (2007)

Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
[17200157] Am J Physiol Renal Physiol 292(5): F1314-21 (2007)

Who Wins the Competition: TRPV5 or Calbindin-D28K?
[17021264] J Am Soc Nephrol 17(11): 2954-6 (2006)

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