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  • The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
  • Chang Q; Hoefs S; van der Kemp AW; Topala CN; Bindels RJ; Hoenderop JG
  • Science 2005[Oct]; 310 (5747): 490-3
  • Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
  • |Animals[MESH]
  • |Calcium Channels/genetics/*metabolism[MESH]
  • |Calcium/metabolism[MESH]
  • |Cell Line[MESH]
  • |Cell Membrane/metabolism[MESH]
  • |Cells, Cultured[MESH]
  • |Glucuronidase/antagonists & inhibitors/metabolism[MESH]
  • |Glycosylation[MESH]
  • |Humans[MESH]
  • |Hydrolysis[MESH]
  • |Kidney/cytology/metabolism[MESH]
  • |Membrane Proteins/*metabolism[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mutation[MESH]
  • |Patch-Clamp Techniques[MESH]
  • |Protein Transport[MESH]
  • |Rabbits[MESH]
  • |Sodium/metabolism[MESH]
  • |TRPV Cation Channels/genetics/*metabolism[MESH]
  • |Transfection[MESH]





  • *{{pmid16239475}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=16239475 The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel ]</b> Science 2005; 310(5747) ; 490-3 Chang Q; Hoefs S; van der Kemp AW; Topala CN; Bindels RJ; Hoenderop JG

        *16239475*

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    Science

    490 5747.310 2005