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  • Calcium absorption across epithelia
  • Hoenderop JG; Nilius B; Bindels RJ
  • Physiol Rev 2005[Jan]; 85 (1): 373-422
  • Ca(2+) is an essential ion in all organisms, where it plays a crucial role in processes ranging from the formation and maintenance of the skeleton to the temporal and spatial regulation of neuronal function. The Ca(2+) balance is maintained by the concerted action of three organ systems, including the gastrointestinal tract, bone, and kidney. An adult ingests on average 1 g Ca(2+) daily from which 0.35 g is absorbed in the small intestine by a mechanism that is controlled primarily by the calciotropic hormones. To maintain the Ca(2+) balance, the kidney must excrete the same amount of Ca(2+) that the small intestine absorbs. This is accomplished by a combination of filtration of Ca(2+) across the glomeruli and subsequent reabsorption of the filtered Ca(2+) along the renal tubules. Bone turnover is a continuous process involving both resorption of existing bone and deposition of new bone. The above-mentioned Ca(2+) fluxes are stimulated by the synergistic actions of active vitamin D (1,25-dihydroxyvitamin D(3)) and parathyroid hormone. Until recently, the mechanism by which Ca(2+) enter the absorptive epithelia was unknown. A major breakthrough in completing the molecular details of these pathways was the identification of the epithelial Ca(2+) channel family consisting of two members: TRPV5 and TRPV6. Functional analysis indicated that these Ca(2+) channels constitute the rate-limiting step in Ca(2+)-transporting epithelia. They form the prime target for hormonal control of the active Ca(2+) flux from the intestinal lumen or urine space to the blood compartment. This review describes the characteristics of epithelial Ca(2+) transport in general and highlights in particular the distinctive features and the physiological relevance of the new epithelial Ca(2+) channels accumulating in a comprehensive model for epithelial Ca(2+) absorption.
  • |Absorption/physiology[MESH]
  • |Animals[MESH]
  • |Biological Transport/physiology[MESH]
  • |Calcium Channels/chemistry/*physiology[MESH]
  • |Calcium/*metabolism[MESH]
  • |Epithelial Cells/*metabolism[MESH]
  • |Humans[MESH]





  • *{{pmid15618484}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=15618484 Calcium absorption across epithelia ]</b> Physiol Rev 2005; 85(1) ; 373-422 Hoenderop JG; Nilius B; Bindels RJ

        *15618484*

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    Physiol Rev

    373 1.85 2005