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  • The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease
  • van Abel M; Hoenderop JG; Bindels RJ
  • Naunyn Schmiedebergs Arch Pharmacol 2005[Apr]; 371 (4): 295-306
  • The epithelial Ca(2+) channels TRPV5 and TRPV6 represent a new family of Ca(2+) channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca(2+) (re)absorption makes it a prime target for regulation to maintain Ca(2+) balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca(2+) channels.
  • |Animals[MESH]
  • |Calcium Channels/*metabolism[MESH]
  • |Calcium/*metabolism[MESH]
  • |Cell Membrane/metabolism[MESH]
  • |Disease/*etiology[MESH]
  • |Epithelium/*metabolism[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Protein Transport[MESH]
  • |TRPV Cation Channels/*metabolism[MESH]





  • *{{pmid15747113}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=15747113 The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease ]</b> Naunyn Schmiedebergs Arch Pharmacol 2005; 371(4) ; 295-306 van Abel M; Hoenderop JG; Bindels RJ

        *15747113*

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    Naunyn Schmiedebergs Arch Pharmacol

    295 4.371 2005