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lüll (Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6 Nijenhuis T; Hoenderop JG; Nilius B; Bindels RJPflugers Arch 2003[Jul]; 446 (4): 401-9The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca(2+) channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca(2+) channels.|Animals[MESH]|Calcium Channels/*physiology[MESH]|Calcium/*metabolism[MESH]|Epithelial Cells/*physiology[MESH]|Humans[MESH]|Metabolic Diseases/metabolism/*physiopathology[MESH]|TRPV Cation Channels[MESH] |