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lüll TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate Nijenhuis T; Hoenderop JG; Bindels RJPflugers Arch 2005[Oct]; 451 (1): 181-92Many physiological functions rely on the exact maintenance of body Ca(2+) balance. Therefore, the extracellular Ca(2+) concentration is tightly regulated by the concerted actions of intestinal Ca(2+) absorption, exchange of Ca(2+) to and from bone, and renal Ca(2+) reabsorption. Renal distal convoluted and connecting tubular cells as well as duodenal epithelial cells are unique in their ability to mediate transcellular (re)absorption of Ca(2+) at large and highly variable rates. Two members of the transient receptor potential (TRP) superfamily, TRP vanilloid (TRPV)5 and TRPV6, are specialized epithelial Ca(2+) channels responsible for the critical Ca(2+) entry step in transcellular Ca(2+) (re)absorption in intestine and kidney, respectively. Because transcellular Ca(2+) transport is fine-tuned to the body's specific requirements, regulation of the transmembrane Ca(2+) flux through TRPV5/6 is of particular importance and has, therefore, to be conspicuously controlled. We present an overview of the current knowledge and recent advances concerning the coordinated regulation of Ca(2+) influx through the epithelial Ca(2+) channels TRPV5 and TRPV6 in transcellular Ca(2+) (re)absorption.|Androgens/pharmacology[MESH]|Animals[MESH]|Annexin A2/physiology[MESH]|Calcitriol/physiology[MESH]|Calcium Channels/*physiology[MESH]|Calcium-Binding Proteins[MESH]|Calcium/*metabolism[MESH]|Calmodulin/pharmacology[MESH]|Cytoskeletal Proteins/physiology[MESH]|Diet[MESH]|Epithelium/drug effects/metabolism[MESH]|Estrogens/pharmacology[MESH]|Feedback, Physiological[MESH]|Glucosidases[MESH]|Humans[MESH]|Hydrogen-Ion Concentration[MESH]|Immediate-Early Proteins/physiology[MESH]|Immunosuppressive Agents/pharmacology[MESH]|Intracellular Signaling Peptides and Proteins[MESH]|Mice[MESH]|Parathyroid Hormone/physiology[MESH]|Phosphoproteins/physiology[MESH]|Protein Serine-Threonine Kinases/physiology[MESH]|Protein Structure, Quaternary[MESH]|S100 Proteins/physiology[MESH]|Sodium Chloride Symporter Inhibitors/pharmacology[MESH]|Sodium-Hydrogen Exchangers[MESH]|TRPV Cation Channels/*physiology[MESH] |