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lüll The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport Markadieu N; Bindels RJ; Hoenderop JGInt J Biochem Cell Biol 2011[Jan]; 43 (1): 1-4The renal connecting tubule (CNT) localizes to the distal part of the nephron between the distal convoluted tubule and the collecting duct, and consists of two different cell types: segment-specific and intercalated cells. The former reabsorb water (H(2)O), sodium (Na(+)) and calcium (Ca(2+)) ions to the blood compartment, while secreting potassium ions (K(+)) into the pro-urine. The latter cells contribute to the renal control of the acid-base balance. Several factors and hormones tightly regulate these transport processes. Although the CNT reabsorbs only approximately 15% of filtered Ca(2+) load, this segment is finally decisive for the amount of Ca(2+) that appears in the urine. Impaired Ca(2+) transport across CNT can provoke severe urinary Ca(2+) excretion, called hypercalciuria. This review mainly focuses on the activity, abundance and expression of the epithelial Ca(2+) channel named Transient Receptor Potential Vanilloid 5 (TRPV5) that is the gatekeeper of active Ca(2+) reabsorption in the CNT.|*Calcium/metabolism[MESH]|*Ion Transport/physiology[MESH]|Acid-Base Equilibrium/physiology[MESH]|Animals[MESH]|Epithelial Cells/pathology/*physiology[MESH]|Female[MESH]|Hormones/metabolism[MESH]|Humans[MESH]|Kidney Tubules, Distal/anatomy & histology/pathology/*physiology[MESH]|Kidney/anatomy & histology/pathology/*physiology[MESH]|Male[MESH]|Mice[MESH]|Potassium/metabolism[MESH]|Sodium/metabolism[MESH]|TRPV Cation Channels/metabolism[MESH]|Water/metabolism[MESH] |