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Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+ van de Graaf SF; Boullart I; Hoenderop JG; Bindels RJJ Steroid Biochem Mol Biol 2004[May]; 89-90 (1-5): 303-8Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed.|*Diet[MESH]|Animals[MESH]|Calcitriol/*pharmacology[MESH]|Calcium Channels/*drug effects/metabolism[MESH]|Calcium/*administration & dosage[MESH]|Epithelial Cells/metabolism[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|TRPV Cation Channels[MESH] |
