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  • Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+
  • van de Graaf SF; Boullart I; Hoenderop JG; Bindels RJ
  • J Steroid Biochem Mol Biol 2004[May]; 89-90 (1-5): 303-8
  • Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed.
  • |*Diet[MESH]
  • |Animals[MESH]
  • |Calcitriol/*pharmacology[MESH]
  • |Calcium Channels/*drug effects/metabolism[MESH]
  • |Calcium/*administration & dosage[MESH]
  • |Epithelial Cells/metabolism[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Mice, Knockout[MESH]
  • |TRPV Cation Channels[MESH]





  • *{{pmid15225790}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=15225790 Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+ ]</b> J Steroid Biochem Mol Biol 2004; 89-90(1-5) ; 303-8 van de Graaf SF; Boullart I; Hoenderop JG; Bindels RJ

        *15225790*

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    J Steroid Biochem Mol Biol

    303 1-5.89-90 2004