TGF beta

The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions.
[11080174] J Neurochem 75(6): 2227-40 (2000)

Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.
[18400189] Immunity 28(4): 468-76 (2008)

Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells.
[16556256] Immunology 117(4): 433-42 (2006)

TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells.
[14966194] J Leukoc Biol 76(1): 15-24 (2004)

Transforming growth factor-beta as a regulator of site-specific T-cell inflammatory response.
[12869133] Scand J Immunol 58(2): 129-38 (2003)

TGFbeta1, back to the future: revisiting its role as a transforming growth factor.
[15034302] Cancer Biol Ther 3(3): 276-83 (2004)

p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta.
[14963407] Cancer Biol Ther 3(2): 226-7 (2004)

Escaping from the TGFbeta anti-proliferative control.
[16698802] Carcinogenesis 27(11): 2148-56 (2006)

TGF-beta signal transduction in oro-facial health and non-malignant disease (part I).
[15574677] Crit Rev Oral Biol Med 15(6): 324-36 (2004)

The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).
[15574678] Crit Rev Oral Biol Med 15(6): 337-47 (2004)

TGF-beta signaling and the fibrotic response.
[15117886] FASEB J 18(7): 816-27 (2004)

Specificity, diversity, and regulation in TGF-beta superfamily signaling.
[10593858] FASEB J 13(15): 2105-24 (1999)

Some recent advances in the chemistry and biology of transforming growth factor-beta.
[3308901] J Cell Biol 105(3): 1039-45 (1987)

Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations.
[17724448] Lab Invest 87(11): 1077-91 (2007)

TGFbeta pathobiology in the eye.
[16341020] Lab Invest 86(2): 106-15 (2006)

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.
[8317552] Am J Pathol 143(1): 3-9 (1993)

Role of transforming growth factor-beta in hematologic malignancies.
[16484590] Blood 107(12): 4589-96 (2006)

Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis.
[10979943] Blood 96(6): 2022-36 (2000)

The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs.
[16728569] Endocr Relat Cancer 13(2): 379-400 (2006)

Transforming growth factor-beta : biology and clinical relevance.
[15715939] J Biochem Mol Biol 38(1): 1-8 (2005)

TGF-beta-dependent cell growth arrest and apoptosis.
[16248969] J Biochem Mol Biol 35(1): 47-53 (2002)

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability.
[15611103] J Biol Chem 280(9): 7409-12 (2005)

TGF-beta latency: biological significance and mechanisms of activation.
[9170210] Stem Cells 15(3): 190-7 (1997)

TGF-beta: a master of all T cell trades.
[18692464] Cell 134(3): 392-404 (2008)

Vulvar vestibulitis syndrome: a review.
[15927350] Eur J Obstet Gynecol Reprod Biol 123(1): 9-16 (2005)

Latent transforming growth factor-beta: structural features and mechanisms of activation.
[9150447] Kidney Int 51(5): 1376-82 (1997)

IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model.
[20308445] Radiology 255(1): 75-82 (2010)

Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.
[19729474] Am J Pathol 175(4): 1362-70 (2009)

NFAT transcription factors, the potion mediating "Dr. Jekill-Mr. Hyde" transformation of the TGFβ pathway in cancer cells.
[20935481] Cell Cycle 9(19): 3838-9 (2010)

TGF-beta signaling in renal disease.
[12239251] J Am Soc Nephrol 13(10): 2600-10 (2002)

Mechanism of action and delivery possibilities for TGFbeta1 in the treatment of myocardial ischemia.
[17331484] Cardiovasc Res 74(2): 235-43 (2007)

Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
[16799085] Proc Am Thorac Soc 3(5): 418-23 (2006)

Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.
[16799084] Proc Am Thorac Soc 3(5): 413-7 (2006)

Making sense of latent TGFbeta activation.
[12482908] J Cell Sci 116(Pt 2): 217-24 (2003)

The TGF-beta family: signaling pathways, developmental roles, and tumor suppressor activities.
[12805946] ScientificWorldJournal 2(-): 892-925 (2002)

Tolerogenic dendritic cells: cytokine modulation comes of age.
[16684955] Blood 108(5): 1435-40 (2006)

ALK1 as an emerging target for antiangiogenic therapy of cancer.
[21467543] Blood 117(26): 6999-7006 (2011)

Recent advances in molecular pharmacology of the histamine systems: immune regulatory roles of histamine produced by leukocytes.
[16648666] J Pharmacol Sci 101(1): 19-23 (2006)

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.
[19525102] Curr Opin Cell Biol 21(5): 616-22 (2009)

Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing.
[20075988] EMBO Rep 11(2): 97-105 (2010)

Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease.
[20219694] Int J Biochem Cell Biol 42(6): 809-12 (2010)

Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy.
[16857784] Clin Cancer Res 12(14 Pt 1): 4142-6 (2006)

Pro- and anti-fibrotic effects of TGF-beta in scleroderma.
[18784145] Rheumatology (Oxford) 47 Suppl 5(-): v5-7 (2008)

Regulation of TGF-beta signalling by protein phosphatases.
[20704570] Biochem J 430(2): 191-8 (2010)

TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells.
[19243289] Future Oncol 5(1): 1-3 (2009)

The TGF-beta paradox in human cancer: an update.
[19284383] Future Oncol 5(2): 259-71 (2009)

Mechanisms of the epithelial-mesenchymal transition by TGF-beta.
[19852727] Future Oncol 5(8): 1145-68 (2009)

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.
[16885528] Reproduction 132(2): 179-90 (2006)

Clearance of apoptotic cells: TGF-beta in the balance between inflammation and fibrosis.
[12960252] J Leukoc Biol 74(6): 959-60 (2003)

Review of the activation of TGF-beta in immunity.
[18818372] J Leukoc Biol 85(1): 29-33 (2009)

'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.
[17979848] Immunol Rev 220(-): 199-213 (2007)

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action.
[15180923] Am J Physiol Renal Physiol 287(1): F7-16 (2004)

TGF-beta signal transduction and mesangial cell fibrogenesis.
[12529270] Am J Physiol Renal Physiol 284(2): F243-52 (2003)

Vascular consequences of dietary salt intake.
[19339634] Am J Physiol Renal Physiol 297(2): F237-43 (2009)

Transforming growth factor beta (TGF-beta) and inflammation in cancer.
[20018551] Cytokine Growth Factor Rev 21(1): 49-59 (2010)

Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.
[19892582] Cytokine Growth Factor Rev 20(5-6): 517-21 (2009)

Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment.
[17418684] Semin Nephrol 27(2): 153-60 (2007)

Resistance to transforming growth factor β-mediated tumor suppression in melanoma: are multiple mechanisms in place?
[20656791] Carcinogenesis 31(10): 1710-7 (2010)

Context-dependent regulation of cutaneous immunological responses by TGFbeta1 and its role in skin carcinogenesis.
[17893229] Carcinogenesis 29(1): 9-14 (2008)

SnoN in mammalian development, function and diseases.
[20822955] Curr Opin Pharmacol 10(6): 670-5 (2010)

Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
[19481975] Curr Opin Pharmacol 9(4): 447-53 (2009)

Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.
[20542955] Exp Biol Med (Maywood) 235(7): 796-804 (2010)

What the lung has taught us about latent TGF-beta activation.
[18927350] Am J Respir Cell Mol Biol 39(5): 499-502 (2008)

Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies?
[17492924] Expert Rev Anticancer Ther 7(5): 609-11 (2007)

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury.
[18174271] Am J Physiol Gastrointest Liver Physiol 294(2): G498-505 (2008)

Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis.
[19800967] Free Radic Biol Med 48(1): 1-15 (2010)

Informatics approaches to understanding TGFbeta pathway regulation.
[19855015] Development 136(22): 3729-40 (2009)

The regulation of TGFbeta signal transduction.
[19855013] Development 136(22): 3699-714 (2009)

TGFbeta family signaling: novel insights in development and disease.
[19855012] Development 136(22): 3691-7 (2009)

Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-beta/Smad signaling in DOCA-salt hypertension.
[21792478] Mol Med 17(11-12): 1204-12 (2011)

Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer.
[20848467] Inflamm Bowel Dis 16(11): 1963-8 (2010)

Medical applications of transforming growth factor-beta.
[15931280] Clin Med Res 1(1): 13-20 (2003)

SMAD7: at the interface of TGF-beta and proinflammatory signaling.
[17704440] Perit Dial Int 27(5): 523-5 (2007)

TGF-β signaling in breast cancer cell invasion and bone metastasis.
[21494783] J Mammary Gland Biol Neoplasia 16(2): 97-108 (2011)

Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.
[19396528] J Mammary Gland Biol Neoplasia 14(2): 131-44 (2009)

Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis.
[18949888] Curr Opin Rheumatol 20(6): 713-9 (2008)

Ubiquitin-dependent regulation of TGFbeta signaling in cancer.
[16925950] Neoplasia 8(8): 677-88 (2006)

Targeting the transforming growth factor-beta signaling pathway in human cancer.
[20001556] Expert Opin Investig Drugs 19(1): 77-91 (2010)

Targeting transforming growth factor-beta signaling.
[17906455] Curr Opin Oncol 19(6): 579-85 (2007)

Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?
[18841463] Breast Cancer Res Treat 115(3): 453-95 (2009)

Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis.
[18765947] J Vasc Res 46(2): 119-37 (2009)

Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition.
[21041997] Cells Tissues Organs 193(1-2): 8-22 (2011)

The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells.
[21051857] Cells Tissues Organs 193(1-2): 98-113 (2011)

Role of TGF-β signaling in inherited and acquired myopathies.
[21798096] Skelet Muscle 1(1): 19 (2011)

TGF-beta signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing.
[15795471] J Physiol Pharmacol 56(1): 3-13 (2005)

Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch.
[20108139] Semin Immunopathol 32(2): 149-56 (2010)

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.
[20538542] Trends Immunol 31(6): 220-7 (2010)

TGFbeta1 and Treg cells: alliance for tolerance.
[17977791] Trends Mol Med 13(11): 492-501 (2007)

Roles of Smad3 in TGF-beta signaling during carcinogenesis.
[17725494] Crit Rev Eukaryot Gene Expr 17(4): 281-93 (2007)

Functional role of KLF10 in multiple disease processes.
[20087894] Biofactors 36(1): 8-18 (2010)

Negative regulation of TGF-beta signaling in development.
[15625010] Cell Res 14(6): 441-9 (2004)

Biogenesis and function of fibrillin assemblies.
[19513754] Cell Tissue Res 339(1): 71-82 (2010)

The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.
[19787707] IUBMB Life 61(10): 929-39 (2009)

Cellular and molecular basis for the regulation of inflammation by TGF-beta.
[20410014] J Biochem 147(6): 781-92 (2010)

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.
[21189329] Cancer Res 71(3): 955-63 (2011)

The role of the TGF-beta coreceptor endoglin in cancer.
[21170488] ScientificWorldJournal 10(): 2367-84 (2010)

Pleiotropic effects of transforming growth factor-beta in hematopoietic stem-cell transplantation.
[20671593] Transplantation 90(11): 1139-44 (2010)

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