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lüll Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease Minoo P; Li CInt J Biochem Cell Biol 2010[Jun]; 42 (6): 809-12Lung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-beta (TGFbeta) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFbeta or Wnt signaling pathways.|*Organogenesis[MESH]|*Receptor Cross-Talk[MESH]|Animals[MESH]|Cell Communication[MESH]|Humans[MESH]|Lung/embryology/*physiology[MESH]|Regeneration[MESH]|Respiratory Mucosa/embryology/*physiology[MESH]|Signal Transduction[MESH]|Transforming Growth Factor beta/*metabolism[MESH]|Wnt Proteins/*metabolism[MESH]|Wound Healing[MESH] |