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lüll TGF-beta signal transduction and mesangial cell fibrogenesis Schnaper HW; Hayashida T; Hubchak SC; Poncelet ACAm J Physiol Renal Physiol 2003[Feb]; 284 (2): F243-52Transforming growth factor-beta (TGF-beta) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways that are activated by TGF-beta. This knowledge is being applied to glomerular mesangial cell models of extracellular matrix (ECM) accumulation. A central component of TGF-beta-stimulated mesangial cell fibrogenesis is the TGF-beta family-specific Smad signal transduction pathway. However, while Smads play an important role in collagen accumulation, recent findings indicate that cross talk among a variety of pathways is necessary for maximal stimulation of collagen expression. Further investigation of these multiple interactions will provide insight into possible ways to interrupt cellular mechanisms of glomerular fibrogenesis.|*Signal Transduction[MESH]|Animals[MESH]|Fibrosis[MESH]|Glomerular Mesangium/*pathology[MESH]|Glomerulosclerosis, Focal Segmental/*etiology[MESH]|Humans[MESH]|Transforming Growth Factor beta/*metabolism[MESH] |