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lüll TGF-beta: a master of all T cell trades Li MO; Flavell RACell 2008[Aug]; 134 (3): 392-404A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained in the peripheral lymphoid organs. Recent studies have defined the cytokine transforming growth factor-beta (TGF-beta) as a critical regulator of thymic T cell development as well as a crucial player in peripheral T cell homeostasis, tolerance to self antigens, and T cell differentiation during the immune response. The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells.|Animals[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Mice[MESH]|T-Lymphocytes/cytology/*immunology[MESH]|Thymus Gland/cytology/immunology[MESH]|Transforming Growth Factor beta/*immunology[MESH] |