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lüll Role of transforming growth factor-beta in inflammatory bowel disease and colitis-associated colon cancer Feagins LAInflamm Bowel Dis 2010[Nov]; 16 (11): 1963-8Transforming growth factor-beta (TGF-beta) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-beta can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-beta in the pathogenesis of inflammatory bowel disease and how TGF-beta might contribute to the cancer risk associated with chronic inflammation of the gut.|Animals[MESH]|Cell Proliferation[MESH]|Cell Transformation, Neoplastic/immunology[MESH]|Colitis/*immunology/pathology[MESH]|Colonic Neoplasms/*immunology/pathology[MESH]|Humans[MESH]|Inflammatory Bowel Diseases/*immunology/pathology[MESH]|Lymphocyte Activation/immunology[MESH]|Mice[MESH]|Th17 Cells/immunology[MESH]|Transforming Growth Factor beta/*immunology[MESH] |