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  • Tolerogenic dendritic cells: cytokine modulation comes of age
  • Rutella S; Danese S; Leone G
  • Blood 2006[Sep]; 108 (5): 1435-40
  • Dendritic cells (DCs) include a heterogeneous family of professional APCs involved in initiation of immunity and in immunologic tolerance. Specifically, peripheral tolerance can be achieved and maintained by promoting regulatory T-cell (Treg) responses and/or T-cell anergy or deletion. Until recently, immature developmental stages of DC differentiation were believed to induce T-cell anergy or Treg cells, whereas DCs transformed into mature DCs by activation stimuli were thought to represent immunogenic DCs capable of inciting primary T-cell responses. This paradigm has been challenged by the demonstration of Treg-cell expansion by antigen-bearing, fully mature DCs. Similarly, semimature DCs with a distinctive interleukin 10 (IL-10)+ IL-12- cytokine production profile might be endowed with tolerogenic functions, supporting the concept that DC maturation per se should no longer be considered as a distinguishing feature of immunogenic as opposed to tolerogenic DCs (TDCs). Cytokine-modulated TDCs reflect an incomplete or altered status of monocyte differentiation and promote in vitro induction of Treg cells and/or in vivo protection from autoimmune diseases. Several growth factors, including IL-10, transforming growth factor beta (TGF-beta), granulocyte colony-stimulating factor (G-CSF), hepatocyte growth factor (HGF), and vasoactive intestinal peptide (VIP), modulate DC maturation and favor the differentiation of TDCs. From a therapeutic standpoint, cytokine-modulated TDCs might be beneficial for prevention and/or treatment of posttransplantation graft-versus-host disease (GVHD) and autoimmunity.
  • |*Immune Tolerance[MESH]
  • |Aging/*immunology[MESH]
  • |Cell Differentiation/drug effects[MESH]
  • |Cytokines/*immunology/pharmacology[MESH]
  • |Dendritic Cells/cytology/*immunology[MESH]
  • |Humans[MESH]
  • |T-Lymphocytes/immunology[MESH]

  • *{{pmid16684955}}
    *<b>[ Tolerogenic dendritic cells: cytokine modulation comes of age ]</b> Blood 2006; 108(5) ; 1435-40 Rutella S; Danese S; Leone G


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    1435 5.108 2006