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  • Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
  • Taylor A; Verhagen J; Blaser K; Akdis M; Akdis CA
  • Immunology 2006[Apr]; 117 (4): 433-42
  • Specific immune suppression and induction of tolerance are essential processes in the regulation and circumvention of immune defence. The balance between allergen-specific type 1 regulatory (Tr1) cells and T helper (Th) 2 cells appears to be decisive in the development of allergy. Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals. In contrast, there is a high frequency of allergen-specific interleukin-4 (IL-4)-secreting T cells in allergic individuals. Allergen-specific immunotherapy can induce specific Tr1 cells that abolish allergen-induced proliferation of Th1 and Th2 cells, as well as their cytokine production. Tr1 cells utilize multiple suppressor mechanisms, such as IL-10 and transforming growth factor-beta (TGF-beta) as secreted cytokines and various surface molecules, such as cytotoxic T-lymphocyte antigen 4 and programmed death-1. IL-10 only inhibits T cells stimulated by low numbers of triggered T-cell receptors, which depend on CD28 costimulation. IL-10 inhibits CD28 tyrosine phosphorylation, preventing the binding of phosphatidylinositol 3-kinase p85 and consequently inhibiting the CD28 signalling pathway. In addition, IL-10 and TGF-beta secreted by Tr1 cells skew the antibody production from immunoglobulin E (IgE) towards the non-inflammatory isotypes IgG4 and IgA, respectively. Induction of antigen-specific Tr1 cells can thus re-direct an inappropriate immune response against allergens or auto-antigens using a broad range of suppressor mechanisms.
  • |Allergens/immunology[MESH]
  • |Humans[MESH]
  • |Immune Tolerance/*immunology[MESH]
  • |Immunoglobulin Isotypes/biosynthesis[MESH]
  • |Immunotherapy[MESH]
  • |Interleukin-10/*immunology[MESH]
  • |Lymphocyte Activation/immunology[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]
  • |Transforming Growth Factor beta/*immunology[MESH]





  • *{{pmid16556256}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=16556256 Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells ]</b> Immunology 2006; 117(4) ; 433-42 Taylor A; Verhagen J; Blaser K; Akdis M; Akdis CA

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    Immunology

    433 4.117 2006