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lüll Regulation of TGF-beta signalling by protein phosphatases Liu T; Feng XHBiochem J 2010[Sep]; 430 (2): 191-8Tight regulation of TGF-beta (transforming growth factor-beta) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-beta superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-beta signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-beta signalling and the essential role of protein phosphatases in this process.|*Signal Transduction[MESH]|Animals[MESH]|Humans[MESH]|Phosphoprotein Phosphatases/genetics/*metabolism[MESH]|Phosphorylation[MESH]|Receptors, Transforming Growth Factor beta/genetics/metabolism[MESH]|Smad Proteins/genetics/metabolism[MESH]|Transforming Growth Factor beta/genetics/*metabolism[MESH] |