TRPV6

Vanilloid transient receptor potential cation channels: an overview.
[18220815] Curr Pharm Des 14(1): 18-31 (2008)

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.
[15747113] Naunyn Schmiedebergs Arch Pharmacol 371(4): 295-306 (2005)

Calciotropic and magnesiotropic TRP channels.
[18268363] Physiology (Bethesda) 23(): 32-40 (2008)

(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6.
[12748856] Pflugers Arch 446(4): 401-9 (2003)

The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation.
[12765695] Cell Calcium 33(5-6): 497-507 (2003)

The TRPV6 gene, cDNA and protein.
[12765696] Cell Calcium 33(5-6): 509-18 (2003)

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene.
[17129178] J Bone Miner Res 22(2): 274-85 (2007)

Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption.
[10428857] J Biol Chem 274(32): 22739-46 (1999)

Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2.
[11744752] J Physiol 537(Pt 3): 747-61 (2001)

Heavy metal cations permeate the TRPV6 epithelial cation channel.
[21146870] Cell Calcium 49(1): 43-55 (2011)

Homo- and heteromeric assembly of TRPV channel subunits.
[15713749] J Cell Sci 118(Pt 5): 917-28 (2005)

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.
[12574114] EMBO J 22(4): 776-85 (2003)

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6 mediated Ca2+ influx.
[22932896] J Biol Chem (): (2012)

Outer pore architecture of a Ca2+-selective TRP channel.
[14736889] J Biol Chem 279(15): 15223-30 (2004)

Voltage-dependent changes of TRPV6-mediated Ca2+ currents.
[15582993] J Biol Chem 280(8): 7022-9 (2005)

Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.
[15123711] J Biol Chem 279(28): 28855-61 (2004)

Ca2+ dependence of the Ca2+-selective TRPV6 channel.
[15184369] J Biol Chem 279(35): 36546-52 (2004)

Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.
[12077127] J Biol Chem 277(34): 30852-8 (2002)

Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.
[12601087] J Gen Physiol 121(3): 245-60 (2003)

TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.
[16044309] Pflugers Arch 451(1): 181-92 (2005)

Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.
[16959851] J Physiol 577(Pt 1): 31-44 (2006)

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
[22354706] J Struct Funct Genomics 13(2): 91-100 (2012)

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P(2).
[21810903] FASEB J 25(11): 3915-28 (2011)

Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels.
[18390907] J Biol Chem 283(22): 14980-7 (2008)

Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport.
[19073818] Mol Pharmacol 75(3): 608-16 (2009)

Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.
[22378746] Am J Physiol Cell Physiol 302(10): C1479-91 (2012)

Regulation of TRPV5 and TRPV6 by associated proteins.
[16682485] Am J Physiol Renal Physiol 290(6): F1295-302 (2006)

Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.
[17233615] Biochem Soc Trans 35(Pt 1): 115-9 (2007)

Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.
[12660155] EMBO J 22(7): 1478-87 (2003)

The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia.
[18187190] Cell Calcium 44(2): 147-57 (2008)

Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat.
[15192090] J Biol Chem 279(33): 34456-63 (2004)

PDZ domain-containing protein as a physiological modulator of TRPV6.
[17645868] Biochem Biophys Res Commun 361(2): 433-8 (2007)

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.
[16565876] Pflugers Arch 452(4): 407-17 (2006)

Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.
[22627147] Channels (Austin) 6(2): 94-102 (2012)

Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity.
[18392847] Pflugers Arch 457(1): 91-101 (2008)

Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.
[20843805] J Biol Chem 285(47): 36586-96 (2010)

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.
[18768590] Am J Physiol Renal Physiol 295(5): F1472-84 (2008)

Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice.
[20181799] Endocrinology 151(4): 1829-36 (2010)

Significance of SGK1 in the regulation of neuronal function.
[20530112] J Physiol 588(Pt 18): 3349-54 (2010)

Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3.
[18005662] FEBS Lett 581(29): 5586-90 (2007)

Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.
[20041238] J Membr Biol 233(1-3): 35-41 (2010)

ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation.
[19805577] FASEB J 24(2): 425-35 (2010)

G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation.
[21349844] J Biol Chem 286(15): 13184-92 (2011)

RGS2 inhibits the epithelial Ca2+ channel TRPV6.
[16895908] J Biol Chem 281(40): 29669-74 (2006)

Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.
[16354700] Mol Cell Biol 26(1): 303-12 (2006)

Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line.
[16529812] Cell Calcium 39(5): 401-15 (2006)

Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels.
[12011062] J Biol Chem 277(30): 26950-8 (2002)

CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes.
[12361955] J Biol Chem 277(49): 47175-83 (2002)

Klotho prevents renal calcium loss.
[19713312] J Am Soc Nephrol 20(11): 2371-9 (2009)

The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.
[18495742] Nephrol Dial Transplant 23(11): 3397-402 (2008)

Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D(3)-enhanced duodenal calcium transport in male mice.
[22275752] Am J Physiol Endocrinol Metab 302(8): E903-13 (2012)

Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo.
[17556365] J Biol Chem 282(31): 22344-52 (2007)

Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor.
[17223545] J Steroid Biochem Mol Biol 103(3-5): 389-95 (2007)

The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells.
[16574738] Mol Endocrinol 20(6): 1447-61 (2006)

Molecular Mechanisms of Vitamin D Action.
[22782502] Calcif Tissue Int (): (2012)

1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells.
[18651709] Eur J Immunol 38(8): 2210-8 (2008)

Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands.
[18290715] J Bone Miner Res 22 Suppl 2(): V2-10 (2007)

Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis.
[18290714] J Bone Miner Res 22 Suppl 2(): V16-9 (2007)

Compensatory induction of the TRPV6 channel in a calbindin-D9k knockout mouse: Its regulation by 1,25-hydroxyvitamin D3.
[19777446] J Cell Biochem 108(5): 1175-83 (2009)

Membrane receptor-initiated signaling in 1,25(OH)2D3-stimulated calcium uptake in intestinal epithelial cells.
[18773429] J Cell Biochem 105(4): 1109-16 (2008)

1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism.
[17293108] J Steroid Biochem Mol Biol 103(3-5): 381-8 (2007)

Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.
[15225790] J Steroid Biochem Mol Biol 89-90(1-5): 303-8 (2004)

Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
[18287084] Proc Natl Acad Sci U S A 105(7): 2598-603 (2008)

Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.
[11687634] Proc Natl Acad Sci U S A 98(23): 13324-9 (2001)

The negative effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder.
[19490920] Life Sci 85(3-4): 146-52 (2009)

Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore.
[20008516] Mol Pharmacol 77(3): 368-77 (2010)

Pharmacology of vanilloid transient receptor potential cation channels.
[19297520] Mol Pharmacol 75(6): 1262-79 (2009)

Chemical inhibitors of the calcium entry channel TRPV6.
[21057859] Pharm Res 28(2): 322-30 (2011)

Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
[19996302] Mol Cancer Res 7(12): 2000-10 (2009)

Rapid effects of 17beta-estradiol on epithelial TRPV6 Ca2+ channel in human T84 colonic cells.
[18395250] Cell Calcium 44(5): 441-52 (2008)

Trpv5/6 is vital for epithelial calcium uptake and bone formation.
[21670068] FASEB J 25(9): 3197-207 (2011)

Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation.
[18276610] Hum Mol Genet 17(11): 1613-8 (2008)

Epithelial Ca2+ and Mg2+ channels in health and disease.
[15574510] J Am Soc Nephrol 16(1): 15-26 (2005)

Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.
[12869611] J Physiol 551(Pt 3): 729-40 (2003)

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.
[22878123] Am J Physiol Gastrointest Liver Physiol (): (2012)

Mechanisms and regulation of epithelial Ca2+ absorption in health and disease.
[17850211] Annu Rev Physiol 70(): 257-71 (2008)

Calcium absorption across epithelia.
[15618484] Physiol Rev 85(1): 373-422 (2005)

Epithelial calcium channels: from identification to function and regulation.
[12684797] Pflugers Arch 446(3): 304-8 (2003)

Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption.
[19779013] Am J Physiol Gastrointest Liver Physiol 297(6): G1193-7 (2009)

Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6.
[16901990] Am J Physiol Gastrointest Liver Physiol 292(1): G92-7 (2007)

Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis.
[20399919] Bone 47(2): 301-8 (2010)

TRP channels in the digestive system.
[20932260] Curr Pharm Biotechnol 12(1): 24-34 (2011)

Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin.
[20463051] Endocrinology 151(7): 2974-84 (2010)

The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes.
[19423758] Endocrinology 150(8): 3448-56 (2009)

Intestinal calcium absorption: Molecular vitamin D mediated mechanisms.
[12520535] J Cell Biochem 88(2): 332-9 (2003)

Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.
[12480925] Lab Invest 82(12): 1755-64 (2002)

Two-step stimulation of intestinal Ca(2+) absorption during lactation by long-term prolactin exposure and suckling-induced prolactin surge.
[19567804] Am J Physiol Endocrinol Metab 297(3): E609-19 (2009)

Effects of furosemide on renal calcium handling.
[17652376] Am J Physiol Renal Physiol 293(4): F1231-7 (2007)

Characterization of a murine renal distal convoluted tubule cell line for the study of transcellular calcium transport.
[14625201] Am J Physiol Renal Physiol 286(3): F483-9 (2004)

Effect of thiazide on renal gene expression of apical calcium channels and calbindins.
[15265769] Am J Physiol Renal Physiol 287(6): F1164-70 (2004)

Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney.
[14569082] J Am Soc Nephrol 14(11): 2731-40 (2003)

The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells.
[12138163] J Biol Chem 277(39): 36656-64 (2002)

A rat kidney-specific calcium transporter in the distal nephron.
[10875938] J Biol Chem 275(36): 28186-94 (2000)

Renal adaptation to gentamicin-induced mineral loss.
[22378246] Am J Nephrol 35(3): 279-86 (2012)

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice.
[21732366] J Cell Physiol 227(5): 1951-9 (2012)

1,25-Dihydroxyvitamin D3-induced aortic calcifications in experimental uremia: up-regulation of osteoblast markers, calcium-transporting proteins and osterix.
[21063202] J Hypertens 29(2): 339-48 (2011)

TRP channels in prostate cancer: the good, the bad and the ugly?
[21623387] Asian J Androl 13(5): 673-6 (2011)

Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1.
[12584203] J Biol Chem 278(17): 15381-9 (2003)

TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression.
[15336984] Biochem Biophys Res Commun 322(4): 1359-63 (2004)

TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new "hot" cancer treatment.
[17292493] Biochim Biophys Acta 1773(4): 565-76 (2007)

TRPV6 potentiates calcium-dependent cell proliferation.
[16356545] Cell Calcium 39(2): 163-73 (2006)

High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters.
[22178934] Cell Physiol Biochem 28(5): 813-22 (2011)

The role of the TRPV6 channel in cancer.
[22331416] J Physiol 590(Pt 6): 1369-76 (2012)

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer.
[22807578] Mol Cancer Ther (): (2012)

The role of TRPV6 in breast carcinogenesis.
[18245667] Mol Cancer Ther 7(2): 271-9 (2008)

TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth.
[21347289] PLoS One 6(2): e16856 (2011)

Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry.
[19270724] Oncogene 28(15): 1792-806 (2009)

TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.
[17533368] Oncogene 26(52): 7380-5 (2007)

Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression.
[14586412] Oncogene 22(49): 7858-61 (2003)

Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.
[17299139] Am J Physiol Renal Physiol 292(5): F1345-53 (2007)

Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
[17200157] Am J Physiol Renal Physiol 292(5): F1314-21 (2007)

TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes.
[17550901] J Biol Chem 282(31): 22582-91 (2007)

Acceleration of keratinocyte differentiation by transient receptor potential vanilloid (TRPV6) channel activation.
[21175869] J Eur Acad Dermatol Venereol 25 Suppl 1(): 12-8 (2011)

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