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lüll TRPV6 potentiates calcium-dependent cell proliferation Schwarz EC; Wissenbach U; Niemeyer BA; Strauss B; Philipp SE; Flockerzi V; Hoth MCell Calcium 2006[Feb]; 39 (2): 163-73The Ca(2+) homeostasis within cells controls a diversity of cellular processes including gene transcription, proliferation and apoptosis. Perturbance of Ca(2+) signaling may induce deregulation of cell proliferation and suppression of cell death providing the basis for cancer development. In human prostate cancer, a correlation between the mRNA expression of the Ca(2+) channel TRPV6 and the staging of the cancer has been described. We have analyzed the influence of TRPV6 on cell proliferation within HEK-293 cells. We show that TRPV6 increases cell proliferation of HEK-293 cells in a Ca(2+) dependent manner. The increased proliferation correlates with slightly increased intracellular Ca(2+) levels without interfering with the intrinsic Ca(2+) dependence of HEK-293 cell proliferation. Low doses of econazole inhibit both, TRPV6 dependent Ca(2+) signals and cell proliferation while BTP2, a potent inhibitor of Ca(2+) signals and cell proliferation in T-cells, neither influences TRPV6 dependent Ca(2+) signals nor cell proliferation of HEK-293 cells. Our data demonstrate that TRPV6 increases the rate of Ca(2+) dependent cell proliferation which is a prerequisite for its potential role in tumor progression.|*Cell Proliferation/drug effects[MESH]|Anilides/pharmacology[MESH]|Calcium Channels/genetics/*metabolism[MESH]|Calcium Signaling/drug effects/*physiology[MESH]|Cell Line[MESH]|Cell Survival[MESH]|Econazole/pharmacology[MESH]|Gene Expression[MESH]|Humans[MESH]|Male[MESH]|Prostatic Neoplasms/genetics/metabolism[MESH]|Recombinant Proteins/genetics/metabolism[MESH]|TRPV Cation Channels/genetics/*metabolism[MESH]|Thiadiazoles/pharmacology[MESH]|Transfection[MESH] |