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Statistics and trial design
LE WE PMID CA
Statistics and trial design13Statistik und Studiendesign

Bayesian statistics

Bioinformatics

Biomarker (BASKET)

Case study approach

Data mining

Drug development

Epidemiology

Evidence based medicine

Genomic and genetic analysis

Glucocorticoids

Informed consent

Intention to treat

Kidney (BASKET)

Microarray (Gene expression analysis)

Neoplasia (Study endpoint)

Neoplasia (Tumor biology and immunology)

Network meta analysis

Nicotine

Number needed to treat

Pediatrics

Personalized medicine

Plazebo

Publication issues

Research ethics

Sepsis

Statistics and trial design

Systematic review

Systemic lupus erythematosus

2006  
1
A primer on the use of modern missing-data methods in psychosomatic medicine research.
[16738075] Psychosom Med 68(3): 427-36 (2006)
1997  
2
Multilevel statistical models for psychosomatic research.
[9251152] Psychosom Med 59(4): 350-1 (1997)
1991  
3
2010  
4
The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews.
[20156912] BMJ 340(-): c365 (2010)
2009  
5
Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications.
[19666685] BMJ 339(-): b2981 (2009)
2006  
6
Ratio measures in leading medical journals: structured review of accessibility of underlying absolute risks.
[17060338] BMJ 333(7581): 1248 (2006)
2006  
7
Cochrane reviews v industry supported meta-analyses: we should read all reviews with caution.
[17068041] BMJ 333(7574): 916 (2006)
2006  
8
Cochrane reviews v industry supported meta-analyses: has Cochrane really achieved its goals?
[17068040] BMJ 333(7574): 916 (2006)
2006  
9
Cochrane reviews v industry supported meta-analyses: ten questions to assess bias in medical research.
[17068039] BMJ 333(7574): 916-7 (2006)
2006  
10
Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review.
[17028106] BMJ 333(7572): 782 (2006)
2006  
11
The simplest statistical test: how to check for a difference between treatments.
[16735336] BMJ 332(7552): 1256-8 (2006)
2005  
12
Why clinicians are natural bayesians.
[15879401] BMJ 330(7499): 1080-3 (2005)
2005  
13
Readers guide to critical appraisal of cohort studies: 3. Analytical strategies to reduce confounding.
[15860831] BMJ 330(7498): 1021-3 (2005)
2005  
14
Reader's guide to critical appraisal of cohort studies: 2. Assessing potential for confounding.
[15845982] BMJ 330(7497): 960-2 (2005)
2005  
15
Reader's guide to critical appraisal of cohort studies: 1. Role and design.
[15831878] BMJ 330(7496): 895-7 (2005)
2005  
16
Optimal search strategies for retrieving systematic reviews from Medline: analytical survey.
[15619601] BMJ 330(7482): 68 (2005)
2004  
17
Diagnostic tests 4: likelihood ratios.
[15258077] BMJ 329(7458): 168-9 (2004)
2004  
18
2002  
19
Power is indeed irrelevant in interpreting completed studies.
[12458264] BMJ 325(7375): 1304 (2002)
2002  
20
Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis.
[12242181] BMJ 325(7365): 652-4 (2002)
2001  
21
Statistics notes: Analysing controlled trials with baseline and follow up measurements.
[11701584] BMJ 323(7321): 1123-4 (2001)
2001  
22
Sifting the evidence-what's wrong with significance tests?
[11159626] BMJ 322(7280): 226-31 (2001)
2000  
23
The risk of bias from omitted research.
[11021845] BMJ 321(7265): 845-6 (2000)
2000  
24
Statistics notes. The odds ratio.
[10827061] BMJ 320(7247): 1468 (2000)
2000  
25
Scientific, ethical, and logistical considerations in introducing a new operation: a retrospective cohort study from paediatric cardiac surgery.
[10784538] BMJ 320(7243): 1168-73 (2000)
1999  
26
1999  
27
What is meant by intention to treat analysis? Survey of published randomised controlled trials.
[10480822] BMJ 319(7211): 670-4 (1999)
1999  
28
A change in scientific approach: from alternation to randomised allocation in clinical trials in the 1940s.
[10463905] BMJ 319(7209): 572-3 (1999)
1999  
29
Understanding controlled trials. Randomisation methods: concealment.
[10435967] BMJ 319(7206): 375-6 (1999)
1999  
30
Statistics notes: variables and parameters.
[10373171] BMJ 318(7199): 1667 (1999)
1999  
31
Numbers needed to treat derived from meta-analyses--sometimes informative, usually misleading.
[10356018] BMJ 318(7197): 1548-51 (1999)
1999  
32
Statistics notes. Treatment allocation in controlled trials: why randomise?
[10221955] BMJ 318(7192): 1209 (1999)
1998  
33
Survival probabilities (the Kaplan-Meier method).
[9836663] BMJ 317(7172): 1572 (1998)
1998  
34
Confidence intervals for the number needed to treat.
[9804726] BMJ 317(7168): 1309-12 (1998)
1998  
35
Bayesians and frequentists.
[9784463] BMJ 317(7166): 1151-60 (1998)
1998  
36
When placebo controlled trials are essential and equivalence trials are inadequate.
[9748192] BMJ 317(7162): 875-80 (1998)
1998  
37
The intracluster correlation coefficient in cluster randomisation.
[9572764] BMJ 316(7142): 1455 (1998)
1998  
38
What's wrong with Bonferroni adjustments.
[9553006] BMJ 316(7139): 1236-8 (1998)
1998  
39
When can odds ratios mislead?
[9550961] BMJ 316(7136): 989-91 (1998)
1998  
40
Understanding controlled trials. What is a patient preference trial?
[9487173] BMJ 316(7128): 360 (1998)
1998  
41
Meta-analysis. Unresolved issues and future developments.
[9468698] BMJ 316(7126): 221-5 (1998)
1998  
42
Understanding controlled trials. Why are randomised controlled trials important?
[9468688] BMJ 316(7126): 201 (1998)
1998  
43
Spurious precision? Meta-analysis of observational studies.
[9462324] BMJ 316(7125): 140-4 (1998)
1998  
44
Statistics notes. Weighted comparison of means.
[9462320] BMJ 316(7125): 129 (1998)
1997  
45
Meta-analysis. Beyond the grand mean?
[9437284] BMJ 315(7122): 1610-4 (1997)
1997  
46
Papers that summarise other papers (systematic reviews and meta-analyses).
[9310574] BMJ 315(7109): 672-5 (1997)
1997  
47
Statistics notes. Trials randomised in clusters.
[9302962] BMJ 315(7108): 600 (1997)
1997  
48
How to read a paper. Statistics for the non-statistician. II: "Significant" relations and their pitfalls.
[9277611] BMJ 315(7105): 422-5 (1997)
1997  
49
How to read a paper. Statistics for the non-statistician. I: Different types of data need different statistical tests.
[9270463] BMJ 315(7104): 364-6 (1997)
1997  
50
Major journals should peer review trials at protocol stage.
[9193306] BMJ 314(7095): 1691-2 (1997)
1997  
51
Statistics notes. Units of analysis.
[9224131] BMJ 314(7098): 1874 (1997)
1996  
52
Statistics notes. Logarithms.
[8597743] BMJ 312(7032): 700 (1996)
1995  
53
Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons.
[7580713] BMJ 311(7013): 1145-8 (1995)
1994  
54
Identifying relevant studies for systematic reviews.
[7718048] BMJ 309(6964): 1286-91 (1994)
1994  
55
Meta-analysis and its problems.
[7950571] BMJ 309(6957): 789-92 (1994)
1994  
56
Some examples of regression towards the mean.
[7950567] BMJ 309(6957): 780 (1994)
1994  
57
Systematic reviews. Some examples.
[7950526] BMJ 309(6956): 719-21 (1994)
1994  
58
Checklists for review articles.
[8086990] BMJ 309(6955): 648-51 (1994)
1994  
59
Rationale for systematic reviews.
[8086953] BMJ 309(6954): 597-9 (1994)
1985  
60
1983  
61
Statistical guidelines for contributors to medical journals.
[6405856] Br Med J (Clin Res Ed) 286(6376): 1489-93 (1983)
1979  
62
1992  
63
Why clinical trials fail: the hidden assumptions of clinical trials.
[1738874] South Med J 85(2): 117-8 (1992)
2002  
64
The nature of truth: Simpson's Paradox and the limits of statistical data.
[11937652] QJM 95(4): 247-9 (2002)
2000  
65
Confidence limits and the limits of confidence.
[10700483] QJM 93(2): 121-4 (2000)
1999  
66
Bootstrapping: estimating confidence intervals for cost-effectiveness ratios.
[10326078] QJM 92(3): 177-82 (1999)
1998  
67
The significance of non-significance.
[10024920] QJM 91(9): 647-53 (1998)
1998  
68
Likelihood ratios: getting diagnostic testing into perspective.
[9666947] QJM 91(4): 247-58 (1998)
2009  
69
Issues on the selection of non-inferiority margin in clinical trials.
[19302756] Chin Med J (Engl) 122(4): 466-70 (2009)
2008  
70
Imputation methods for missing outcome data in meta-analysis of clinical trials.
[18559412] Clin Trials 5(3): 225-39 (2008)
2005  
71
On criteria for evaluating models of absolute risk.
[15772102] Biostatistics 6(2): 227-39 (2005)
2001  
72
Rethinking historical controls.
[12933631] Biostatistics 2(4): 383-96 (2001)
2004  
73
Twenty statistical errors even you can find in biomedical research articles.
[15311405] Croat Med J 45(4): 361-70 (2004)
2009  
74
Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison.
[19772573] Trials 10(-): 86 (2009)
2009  
75
Design, analysis, and presentation of crossover trials.
[19405975] Trials 10(-): 27 (2009)
2008  
76
A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes.
[18694492] Trials 9(-): 51 (2008)
2009  
77
Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials.
[19536325] PLoS Med 6(5): e1000067 (2009)
2009  
78
Preventing bias in cluster randomised trials.
[19536323] PLoS Med 6(5): e1000065 (2009)
2008  
79
In the era of systematic reviews, does the size of an individual trial still matter.
[18177203] PLoS Med 5(1): e4 (2008)
2009  
80
A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.
[20003383] BMC Pediatr 9(-): 77 (2009)
2006  
81
Conducting research in individual patients: lessons learnt from two series of N-of-1 trials.
[16984636] BMC Fam Pract 7(-): 54 (2006)
2008  
82
Teaching statistics in biology: using inquiry-based learning to strengthen understanding of statistical analysis in biology laboratory courses.
[18765754] CBE Life Sci Educ 7(3): 317-26 (2008)
2009  
83
Application of multivariate probabilistic (Bayesian) networks to substance use disorder risk stratification and cost estimation.
[20169014] Perspect Health Inf Manag 6(-): 1b (2009)
2009  
84
The use of older studies in meta-analyses of medical interventions: a survey.
[19946395] Open Med 3(2): e62-8 (2009)
2008  
85
Meta-analysis of multi-arm trials using empirical logistic transform.
[19606233] Open Med Inform J 2(-): 112-6 (2008)
2009  
86
Meta-analysis: A brief introduction.
[20443922] Clin Transl Sci 2(5): 374-8 (2009)
2009  
87
Bayesian classification of clinical practice guidelines.
[19667308] Arch Intern Med 169(15): 1431-5 (2009)
2004  
88
Statistical issues in interpreting clinical trials.
[15078496] J Intern Med 255(5): 529-37 (2004)
2004  
89
On the evolution of statistical methods as applied to clinical trials.
[15078495] J Intern Med 255(5): 521-8 (2004)
1997  
90
Interpretation of data from multiple trials: a critical review.
[9104430] J Intern Med 241(3): 177-83 (1997)
2007  
91
Power: not only a matter of numbers, but also of design.
[17587644] Neth J Med 65(6): 197-8 (2007)
2008  
92
Meta-analysis: Its strengths and limitations.
[18595551] Cleve Clin J Med 75(6): 431-9 (2008)
2008  
93
Meta-analyses, metaphysics, and reality.
[18595547] Cleve Clin J Med 75(6): 400 (2008)
1999  
94
Misuse of correlation and regression in three medical journals.
[10396255] J R Soc Med 92(3): 123-8 (1999)
1996  
95
1995  
96
Pitfalls in the interpretation of studies: III.
[7636813] J R Soc Med 88(5): 241-3 (1995)
1995  
97
Pitfalls in the interpretation of studies: I.
[7884763] J R Soc Med 88(1): 2-4 (1995)
2009  
98
Standing on the shoulders of giants: Introduction to systematic reviews and meta-analyses.
[19910604] Can Fam Physician 55(11): 1155-6 (2009)
2001  
99
Hypothesis: the research page. Part 3: Power, sample size, and clinical significance.
[11494932] Can Fam Physician 47(-): 1441-3, 1450-3 (2001)
2008  
100
Tips and tricks in performing a systematic review--chapter 4.
[18307870] Br J Gen Pract 58(547): 136 (2008)
2007  
101
Tips and tricks in performing a systematic review.
[18252086] Br J Gen Pract 57(545): 999 (2007)
2007  
102
Tips and tricks in performing a systematic review.
[17504612] Br J Gen Pract 57(538): 425 (2007)
1996  
103
Is there evidence that megatrials are based on a methodological mistake?
[8978123] Br J Gen Pract 46(412): 688 (1996)
1996  
104
Megatrials are based on a methodological mistake.
[8776917] Br J Gen Pract 46(408): 429-31 (1996)
2004  
105
On the nature and analysis of clustered data.
[15209193] Ann Fam Med 2(3): 199-200 (2004)
1979  
106
The four basic types of evaluation: clinical reviews, clinical trials, program reviews, and program trials.
[109896] Public Health Rep 94(3): 210-5 (1979)
1997  
107
Statistics in the journal--significance, confidence, and all that.
[9254553] Am J Public Health 87(7): 1092-5 (1997)
1991  
108
The importance of assessing the fit of logistic regression models: a case study.
[1746660] Am J Public Health 81(12): 1630-5 (1991)
1984  
109
Consensus methods: characteristics and guidelines for use.
[6380323] Am J Public Health 74(9): 979-83 (1984)
2009  
110
Interpreting results in 2 x 2 tables: part 9 of a series on evaluation of scientific publications.
[20038982] Dtsch Arztebl Int 106(48): 795-800 (2009)
2009  
111
Placebo: misunderstandings and prejudices.
[20019863] Dtsch Arztebl Int 106(46): 751-5 (2009)
2009  
112
Avoiding bias in observational studies: part 8 in a series of articles on evaluation of scientific publications.
[19946431] Dtsch Arztebl Int 106(41): 664-8 (2009)
2009  
113
Descriptive statistics: the specification of statistical measures and their presentation in tables and graphs. Part 7 of a series on evaluation of scientific publications.
[19890414] Dtsch Arztebl Int 106(36): 578-83 (2009)
2009  
114
Systematic literature reviews and meta-analyses: part 6 of a series on evaluation of scientific publications.
[19652768] Dtsch Arztebl Int 106(27): 456-63 (2009)
2009  
115
Requirements and assessment of laboratory tests: Part 5 of a series on evaluation of scientific publications.
[19623307] Dtsch Arztebl Int 106(24): 403-6 (2009)
2009  
116
Study design in medical research: part 2 of a series on the evaluation of scientific publications.
[19568374] Dtsch Arztebl Int 106(11): 184-9 (2009)
2009  
117
Critical appraisal of scientific articles: part 1 of a series on evaluation of scientific publications.
[19562021] Dtsch Arztebl Int 106(7): 100-5 (2009)
2008  
118
Independent predictors from stepwise logistic regression may be nothing more than publishable P values.
[19020117] Anesth Analg 107(6): 1775-8 (2008)
2005  
119
2006  
120
Better methods for meta-analysis available.
[16732124] Anesthesiology 104(6): 1350 (2006)
2000  
121
Current issues in clinical trial design: superiority versus equivalency studies.
[10839934] Anesthesiology 92(6): 1814-20 (2000)
2000  
122
Randomized and nonrandomized clinical studies: statistical considerations.
[10754608] Anesthesiology 92(4): 928-30 (2000)
1993  
123
Pitfalls in performing meta-analysis: I.
[8342859] Anesthesiology 79(2): 405 (1993)
1993  
124
Pitfalls in performing meta-analysis: II.
[8380047] Anesthesiology 79(2): 406-8 (1993)
2008  
125
Bench-to-bedside review: avoiding pitfalls in critical care meta-analysis--funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacy.
[18671838] Crit Care 12(4): 220 (2008)
2005  
126
A systematic evaluation of the quality of meta-analyses in the critical care literature.
[16277721] Crit Care 9(5): R575-82 (2005)
2004  
127
Statistics review 13: receiver operating characteristic curves.
[15566624] Crit Care 8(6): 508-12 (2004)
2005  
128
Statistics review 14: Logistic regression.
[15693993] Crit Care 9(1): 112-8 (2005)
2005  
129
Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments.
[15693981] Crit Care 9(1): 34-6; discussion 34-6 (2005)
2004  
130
Statistics review 10: further nonparametric methods.
[15153238] Crit Care 8(3): 196-9 (2004)
2004  
131
Statistics review 9: one-way analysis of variance.
[15025774] Crit Care 8(2): 130-6 (2004)
2004  
132
Statistics review 12: survival analysis.
[15469602] Crit Care 8(5): 389-94 (2004)
2004  
133
Statistics review 11: assessing risk.
[15312212] Crit Care 8(4): 287-91 (2004)
2004  
134
Statistics review 8: Qualitative data - tests of association.
[14975045] Crit Care 8(1): 46-53 (2004)
2003  
135
Statistics review 7: Correlation and regression.
[14624685] Crit Care 7(6): 451-9 (2003)
2002  
136
Statistics review 5: Comparison of means.
[12398782] Crit Care 6(5): 424-8 (2002)
2002  
137
Statistics review 4: sample size calculations.
[12225610] Crit Care 6(4): 335-41 (2002)
2002  
138
Statistics review 3: hypothesis testing and P values.
[12133182] Crit Care 6(3): 222-5 (2002)
2002  
139
Statistics review 6: Nonparametric methods.
[12493072] Crit Care 6(6): 509-13 (2002)
2002  
140
Statistics review 2: samples and populations.
[11983040] Crit Care 6(2): 143-8 (2002)
2002  
141
Statistics review 1: presenting and summarising data.
[11940268] Crit Care 6(1): 66-71 (2002)
2005  
142
Advanced statistics: how to determine whether your intervention is different, at least as effective as, or equivalent: a basic introduction.
[15930406] Acad Emerg Med 12(6): 536-42 (2005)
2004  
143
Advanced statistics: understanding medical record review (MRR) studies.
[14759964] Acad Emerg Med 11(2): 187-92 (2004)
2003  
144
Bayesian modeling and real-world problems.
[12837653] Acad Emerg Med 10(7): 780-2 (2003)
2001  
145
Are clinician-investigators Bayesian?
[11733298] Acad Emerg Med 8(12): 1179-81 (2001)
2000  
146
Research fundamentals: statistical considerations in research design: a simple person's approach.
[10691082] Acad Emerg Med 7(2): 194-9 (2000)
1999  
147
Systematic reviews: a logical methodological extension of evidence-based medicine.
[10609928] Acad Emerg Med 6(12): 1255-60 (1999)
1998  
148
Parametric statistical tests: unnecessary assumptions, computers, and the search for the trustworthy p-value.
[9835464] Acad Emerg Med 5(11): 1048-50 (1998)
1997  
149
Recommended guidelines for reviewing, reporting, and conducting research on in-hospital resuscitation: the in-hospital "Utstein style". A statement for health care professionals from the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, the Australian Resuscitation Council, and the Resuscitation Councils of Southern Africa.
[9189194] Acad Emerg Med 4(6): 603-27 (1997)
2003  
150
Statistical consideration for research.
[12748144] Emerg Med J 20(3): 258-62 (2003)
2003  
151
Designing a research project: randomised controlled trials and their principles.
[12642531] Emerg Med J 20(2): 164-8 (2003)
2003  
152
Observational research methods. Research design II: cohort, cross sectional, and case-control studies.
[12533370] Emerg Med J 20(1): 54-60 (2003)
2002  
153
Overview of research designs.
[12421782] Emerg Med J 19(6): 546-9 (2002)
2001  
154
Article 8. An introduction to hypothesis testing. Non-parametric comparison of two groups-1.
[11435368] Emerg Med J 18(4): 276-82 (2001)
2007  
155
Statistics in review. Part 2: generalised linear models, time-to-event and time-series analysis, evidence synthesis and clinical trials.
[17536991] Crit Care Resusc 9(2): 187-97 (2007)
2007  
156
Statistics in review Part I: graphics, data summary and linear models.
[17352672] Crit Care Resusc 9(1): 81-90 (2007)
2004  
157
Critical care trials: sample size, power and interpretation.
[16556098] Crit Care Resusc 6(4): 239-42 (2004)
2001  
158
Reporting of clinical trials using group sequential methods.
[16573493] Crit Care Resusc 3(3): 146-7 (2001)
2000  
159
Relative risks: relative benefits.
[16597309] Crit Care Resusc 2(4): 244-5 (2000)
2000  
160
The value of the number-needed-to-treat method in antiepileptic drug trials.
[10756410] Epilepsia 41(4): 440-6 (2000)
2004  
161
Methods for analysis of skewed data distributions in psychiatric clinical studies: working with many zero values.
[15229044] Am J Psychiatry 161(7): 1159-68 (2004)
2004  
162
2010  
163
Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable.
[20571520] J Cereb Blood Flow Metab 30(9): 1558-63 (2010)
2005  
164
From the descriptive towards inferential statistics: hundred years since conception of the Student's t-distribution.
[15990717] Neuro Endocrinol Lett 26(3): 167-71 (2005)
2007  
165
Simulation performance checklist generation using the Delphi technique.
[18056208] Can J Anaesth 54(12): 992-7 (2007)
1997  
166
Systematic reviews: the case for rigorous methods and rigorous reporting.
[9104514] Can J Anaesth 44(4): 350-3 (1997)
2007  
167
Consent bias in research: how to avoid it.
[17699171] Heart 93(9): 1024-5 (2007)
2006  
168
2000  
169
Evaluation of large scale clinical trials and their application to usual practice.
[11083755] Heart 84(6): 679-84 (2000)
1988  
170
1989  
171
Understanding investigative clinical trials.
[2651729] J Vasc Surg 9(4): 609-18 (1989)
2006  
172
Methodological issues in cardiovascular epidemiology: the risk of determining absolute risk through statistical models.
[17326336] Vasc Health Risk Manag 2(3): 309-15 (2006)
2007  
173
2007  
174
Bayesian modelling and ROC analysis to predict placebo responders using clinical score measured in the initial weeks of treatment in depression trials.
[17488364] Br J Clin Pharmacol 63(5): 595-613 (2007)
2004  
175
2004  
176
The revision of the Declaration of Helsinki: past, present and future.
[15151515] Br J Clin Pharmacol 57(6): 695-713 (2004)
2002  
177
Is intent-to-treat analysis always (ever) enough?
[12207643] Br J Clin Pharmacol 54(2): 203-11 (2002)
2001  
178
Points to consider on switching between superiority and non-inferiority.
[11560553] Br J Clin Pharmacol 52(3): 223-8 (2001)
2001  
179
Switching between superiority and non-inferiority: an introductory note.
[11560552] Br J Clin Pharmacol 52(3): 221 (2001)
2001  
180
Switching between superiority and non-inferiority.
[11560551] Br J Clin Pharmacol 52(3): 219 (2001)
2001  
181
Stopping rules for phase II studies.
[11422011] Br J Clin Pharmacol 51(6): 523-9 (2001)
1979  
182
Validity of cross-over trials.
[552297] Br J Clin Pharmacol 8(1): 5-6 (1979)
1977  
183
2006  
184
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.
[16968952] Pharmacol Rev 58(3): 621-81 (2006)
2005  
185
Regression methods in the empiric analysis of health care data.
[15804208] J Manag Care Pharm 11(3): 240-51 (2005)
2005  
186
Clinical data gap between phase III clinical trials (pre-marketing) and phase IV (post-marketing) studies: evaluation of etanercept in rheumatoid arthritis.
[16278497] Can J Clin Pharmacol 12(3): e254-63 (2005)
2005  
187
Modeling nonlinear dose-response relationships in epidemiologic studies: statistical approaches and practical challenges.
[18648629] Dose Response 3(4): 474-90 (2005)
2005  
188
The causes and effects of socio-demographic exclusions from clinical trials.
[16181564] Health Technol Assess 9(38): iii-iv, ix-x, 1-152 (2005)
2005  
189
Lay public's understanding of equipoise and randomisation in randomised controlled trials.
[15763039] Health Technol Assess 9(8): 1-192, iii-iv (2005)
2005  
190
Issues in data monitoring and interim analysis of trials.
[15763038] Health Technol Assess 9(7): 1-238, iii-iv (2005)
2004  
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