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Types of clinical studies Systematic reviews Varandas T; Carneiro AVRev Port Cardiol 2006[Feb]; 25 (2): 233-46Systematic reviews are analytic instruments that summarize the best available scientific evidence in order to provide evidence-based answers to clinically relevant questions. Meta-analyses are systematic reviews with a quantitative analysis of results. The process of conducting a systematic review is a rigorous and standardized procedure that includes: 1) formulating a clinically relevant question; 2) explicit selection of studies (primary or secondary) to be included in the review; 3) critical appraisal of the relevant evidence; 4) summarizing the evidence; and 5) statistical analysis of the results. In this paper we describe the steps involved in conducting a systematic review of scientific evidence, the methodology, and problems.|*Review Literature as Topic[MESH]|Clinical Trials as Topic[MESH]|Databases, Bibliographic[MESH]|Evidence-Based Medicine[MESH] |
