LE WE PMID CA
IGF11290IGF1

Atherosclerosis (BASKET)

Autoantibodies Anti IGF1R

Bone (BASKET)

Cachexia (Oncology and BASKET)

Cell senescence

Chalon

Cixutumumab ttIGF1R

Delirium

Diabetes mellitus (Involvement eye)

Diabetes mellitus (Involvement kidney)

DNA (Repair and Toxicology)

DOK1

Donohue s syndrome Leprechaunism

Embryology (BASKET)

ERS UFR (Apoptosis)

FoxO3A

GADD153 CHOP

Glycine proline glutamate GPE

Graves disease

Growth hormone

Growth plate

Growth retardation

IGF1

IGFALS IGF acid labile subunit

IGFBP3

Insulin (BASKET)

Insulin (resistance)

Integrin alphav beta3

Kidney (Chronic renal failure)

Laron s syndrome

Liver (Neoplasia)

Long life

Macrophages

Mammary gland (Neoplasia)

Mecasermin

Metabolic syndrome

MGF

MTOR

Muscle (Physiology)

Myostatin

Neoplasia (Carcinogenesis)

Neoplasia (Tumor biology and immunology)

Neuroprotective agents

Obesity (BASKET)

Osteoarthritis

P38MAPK

P53

Pentose shunt

Placenta (BASKET)

Protein kinase B Akt

PUMA

Rabson Mendenhall s syndrome

Receptor (GH)

Receptor (IGF1)

Receptor (Insulin)

SB212090 ttp38MAPK

SHC

SHP2

SHPS1

SOCS

TRB3

Warburg effect

Wortmannin

2009  
1
Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review.
[19956424] Am J Transl Res 1(2): 101-14 (2009)
2009  
2
Treatment of dwarfism with recombinant human insulin-like growth factor-1.
[19946434] Dtsch Arztebl Int 106(43): 703-9 (2009)
2005  
3
Myostatin, the cardiac chalone of insulin-like growth factor-1.
[16226233] Cardiovasc Res 68(3): 347-9 (2005)
2008  
4
The insulin-like growth factor system and its receptors: A potential novel anticancer target.
[19707463] Biologics 2(4): 855-64 (2008)
2009  
5
Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency.
[19707272] Ther Clin Risk Manag 5(3): 553-9 (2009)
1979  
6
Nutritional regulation of somatomedin.
[373416] Am J Clin Nutr 32(5): 1082-96 (1979)
2008  
7
Inhibition of colon cancer cell growth by dietary components: role of the insulin-like growth factor (IGF) system.
[18296350] Asia Pac J Clin Nutr 17 Suppl 1(-): 257-60 (2008)
2003  
8
Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.
[12795426] Recent Prog Horm Res 58(-): 325-42 (2003)
2007  
9
An overview of currently available anti-insulin-like growth factor I receptor antibodies.
[20103882] Biosci Trends 1(3): 128-33 (2007)
2002  
10
IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.
[12545204] Acta Biochim Pol 49(4): 979-90 (2002)
1999  
11
Differential regulation of signaling pathways for insulin and insulin-like growth factor I.
[10453981] Acta Biochim Pol 46(1): 51-60 (1999)
2009  
12
Targeting insulin-like growth factor type 1 receptor in cancer therapy.
[19876700] Target Oncol 4(4): 255-66 (2009)
2008  
13
Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.
[18790742] Mol Cancer Ther 7(9): 2575-88 (2008)
2007  
14
Disrupting insulin-like growth factor signaling as a potential cancer therapy.
[17237261] Mol Cancer Ther 6(1): 1-12 (2007)
2002  
15
The insulin-like growth factor system as a therapeutic target in colorectal cancer.
[11996463] Ann Oncol 13(3): 349-56 (2002)
2006  
16
Targeting insulin-like growth factor pathways.
[16450000] Br J Cancer 94(4): 465-8 (2006)
1992  
17
Insulin-like growth factors and cancer.
[1313689] Br J Cancer 65(3): 311-20 (1992)
2005  
18
Role of insulin-like growth factor 1 receptor signalling in cancer.
[15956962] Br J Cancer 92(12): 2097-101 (2005)
2008  
19
The type 1 insulin-like growth factor receptor pathway.
[18927274] Clin Cancer Res 14(20): 6364-70 (2008)
2007  
20
IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor.
[17875788] Clin Cancer Res 13(18 Pt 2): 5549s-5555s (2007)
2006  
21
Insulin-like growth factor-I axis as a pathway for cancer chemoprevention.
[17020962] Clin Cancer Res 12(19): 5611-4 (2006)
2002  
22
Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer.
[12096082] J Natl Cancer Inst 94(13): 972-80 (2002)
2000  
23
Role of the insulin-like growth factor family in cancer development and progression.
[10995803] J Natl Cancer Inst 92(18): 1472-89 (2000)
2009  
24
The role of IGF-1R in pediatric malignancies.
[19126579] Oncologist 14(1): 83-91 (2009)
2008  
25
The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer.
[18245009] Oncologist 13(1): 16-24 (2008)
2005  
26
Type I insulin-like growth factor receptor as a therapeutic target in cancer.
[16287993] Cancer Res 65(22): 10123-7 (2005)
2000  
27
The contradictions of the insulin-like growth factor 1 receptor.
[11114737] Oncogene 19(49): 5574-81 (2000)
2007  
28
The role of the IGF system in cancer growth and metastasis: overview and recent insights.
[16931767] Endocr Rev 28(1): 20-47 (2007)
2005  
29
The insulin-like growth factor system and its pleiotropic functions in brain.
[16131630] Endocr Rev 26(7): 916-43 (2005)
2002  
30
Cellular actions of the insulin-like growth factor binding proteins.
[12466191] Endocr Rev 23(6): 824-54 (2002)
2000  
31
The effects of insulin-like growth factors on tumorigenesis and neoplastic growth.
[10857553] Endocr Rev 21(3): 215-44 (2000)
1999  
32
The insulin-like growth factor-binding protein (IGFBP) superfamily.
[10605625] Endocr Rev 20(6): 761-87 (1999)
1998  
33
Insulin-like growth factor-I resistance.
[9793761] Endocr Rev 19(5): 625-46 (1998)
1997  
34
Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.
[9408744] Endocr Rev 18(6): 801-31 (1997)
2000  
35
Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.
[10744620] FASEB J 14(5): 629-40 (2000)
1990  
36
Insulin-like growth factors I and II.
[2197088] Eur J Biochem 190(3): 445-62 (1990)
2002  
37
The role of insulin-like growth factor 2 and its receptors in human tumors.
[12606812] Mol Med 8(12): 771-80 (2002)
2008  
38
Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans.
[18713961] Am J Physiol Endocrinol Metab 295(5): E991-9 (2008)
2003  
39
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.
[14534077] Am J Physiol Endocrinol Metab 285(5): E1064-71 (2003)
2000  
40
Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.
[10826997] Am J Physiol Endocrinol Metab 278(6): E967-76 (2000)
1994  
41
Clinical uses of insulin-like growth factor I.
[8116999] Ann Intern Med 120(7): 593-601 (1994)
2006  
42
2003  
43
Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions.
[14713267] Endocr Relat Cancer 10(4): 561-78 (2003)
2003  
44
Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells.
[12790794] Endocr Relat Cancer 10(2): 331-45 (2003)
2001  
45
2002  
46
Insights from insulin-like growth factor binding protein transgenic mice.
[12239079] Endocrinology 143(10): 3711-4 (2002)
2007  
47
Genetic disorders in the GH IGF-I axis in mouse and man.
[17785692] Eur J Endocrinol 157 Suppl 1(-): S15-26 (2007)
2006  
48
Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer.
[16299029] Gut 55(5): 689-94 (2006)
2007  
49
The somatomedin hypothesis 2007: 50 years later.
[17986643] J Clin Endocrinol Metab 92(12): 4529-35 (2007)
1999  
50
Insulin-like growth factors in pediatric health and disease.
[10599688] J Clin Endocrinol Metab 84(12): 4355-61 (1999)
1999  
51
Insulin-like growth factors and skeletal growth: possibilities for therapeutic interventions.
[10599687] J Clin Endocrinol Metab 84(12): 4349-54 (1999)
1997  
52
The binding protein's binding protein--clinical applications of acid-labile subunit (ALS) measurement.
[9398692] J Clin Endocrinol Metab 82(12): 3941-3 (1997)
2002  
53
Specifying the cellular responses to IGF signals: roles of IGF-binding proteins.
[12379489] J Endocrinol 175(1): 41-54 (2002)
2002  
54
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms.
[12379487] J Endocrinol 175(1): 19-31 (2002)
2002  
55
Comparative endocrinology of the insulin-like growth factor-binding protein.
[12379486] J Endocrinol 175(1): 3-18 (2002)
2001  
56
The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system.
[11431138] J Endocrinol 170(1): 63-70 (2001)
1998  
57
Insulin-like growth factor-binding proteins: functional diversity or redundancy?
[9801453] J Mol Endocrinol 21(2): 97-107 (1998)
2001  
58
The three dimensional structure of the type I insulin-like growth factor receptor.
[11376122] Mol Pathol 54(3): 125-32 (2001)
2000  
59
Insulin growth factor I and hypogonadism in cirrhosis.
[10706573] Hepatology 31(3): 783-4 (2000)
1998  
60
Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor (review).
[9852311] Int J Mol Med 1(5): 883-8 (1998)
2003  
61
Mechanisms by which IGF-I may promote cancer.
[14688466] Cancer Biol Ther 2(6): 630-5 (2003)
2005  
62
The multi-functional role of insulin-like growth factor binding proteins in bone.
[15549410] Pediatr Nephrol 20(3): 261-8 (2005)
2010  
63
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.
[20098959] ScientificWorldJournal 10(-): 161-77 (2010)
2011  
64
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
[21115525] Philos Trans R Soc Lond B Biol Sci 366(1561): 9-16 (2011)
2010  
65
Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium.
[20591980] J Clin Endocrinol Metab 95(9): 4184-91 (2010)
2010  
66
2010  
67
Off-label use of recombinant igf-I to promote growth: is it appropriate?
[20133470] J Clin Endocrinol Metab 95(2): 505-8 (2010)
2004  
68
New molecular mechanisms of GH resistance.
[15339238] Eur J Endocrinol 151 Suppl 1(-): S11-5 (2004)
2003  
69
Central effects of the somatotropic system.
[14585082] Eur J Endocrinol 149(5): 377-92 (2003)
2007  
70
Idiopathic short stature: will genetics influence the choice between GH and IGF-I therapy?
[17785695] Eur J Endocrinol 157 Suppl 1(-): S33-7 (2007)
2007  
71
IGF-I treatment of insulin resistance.
[17785698] Eur J Endocrinol 157 Suppl 1(-): S51-6 (2007)
2007  
72
2009  
73
Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.
[19075184] Endocr Rev 30(1): 51-74 (2009)
2009  
74
Unraveling insulin-like growth factor binding protein-3 actions in human disease.
[19477944] Endocr Rev 30(5): 417-37 (2009)
2009  
75
The role of liver-derived insulin-like growth factor-I.
[19589948] Endocr Rev 30(5): 494-535 (2009)
2011  
76
The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth.
[20921199] J Physiol 589(Pt 1): 7-20 (2011)
2011  
77
State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors.
[21356169] Discov Med 11(57): 144-53 (2011)
2009  
78
IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions.
[19438508] Br J Pharmacol 157(6): 881-91 (2009)
2007  
79
Biological & physiological aspects of action of insulin-like growth factor peptide family.
[17598937] Indian J Med Res 125(4): 511-22 (2007)
2007  
80
Insulin like growth factors and growth hormone deficiency.
[17536135] Indian Pediatr 44(5): 349-53 (2007)
2010  
81
CSF-1, IGF-1, and the control of postnatal growth and development.
[20519640] J Leukoc Biol 88(3): 475-81 (2010)
2010  
82
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
[20399660] Trends Cell Biol 20(7): 427-34 (2010)
2010  
83
Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systems.
[20032049] Endocrinology 151(4): 1403-8 (2010)
2010  
84
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.
[20130113] Endocrinology 151(3): 865-75 (2010)
2010  
85
The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.
[20631046] J Endocrinol 206(3): 249-59 (2010)
2010  
86
Maternal growth factor regulation of human placental development and fetal growth.
[20817666] J Endocrinol 207(1): 1-16 (2010)
2009  
87
Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
[19180501] Arthritis Rheum 60(2): 492-500 (2009)
2009  
88
The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.
[18801901] Endocrinology 150(1): 277-85 (2009)
2010  
89
Basic and clinical significance of IGF-I-induced signatures in cancer.
[20051101] BMC Med 8(-): 2 (2010)
2010  
90
The proliferating role of insulin and insulin-like growth factors in cancer.
[20663687] Trends Endocrinol Metab 21(10): 610-8 (2010)
2010  
91
IGF-1, oxidative stress and atheroprotection.
[20071192] Trends Endocrinol Metab 21(4): 245-54 (2010)
2010  
92
Defining the pathway to insulin-like growth factor system targeting in cancer.
[20599789] Biochem Pharmacol 80(8): 1115-24 (2010)
2007  
93
From broken to old: DNA damage, IGF1 endocrine suppression and aging.
[17481965] DNA Repair (Amst) 6(9): 1386-90 (2007)
2009  
94
Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies.
[19491931] Eur J Hum Genet 17(12): 1668-75 (2009)
2010  
95
Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
[20392809] Pharmacol Rev 62(2): 199-236 (2010)
2010  
96
Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.
[20975071] J Clin Oncol 28(33): 4985-95 (2010)
2011  
97
Targeting insulin-like growth factor axis in hepatocellular carcinoma.
[21729319] J Hematol Oncol 4(-): 30 (2011)
2008  
98
IGF-1 receptor inhibitors in clinical trials--early lessons.
[19023648] J Mammary Gland Biol Neoplasia 13(4): 471-83 (2008)
2009  
99
2009  
100
Running on empty: how p53 controls INS/IGF signaling and affects life span.
[18598747] Exp Gerontol 44(1-2): 93-100 (2009)
2003  
101
The insulin-like growth factor system.
[14668044] Exp Diabesity Res 4(4): 205-12 (2003)
2003  
102
The role of the insulin-like growth factors and their binding proteins in glucose homeostasis.
[14668045] Exp Diabesity Res 4(4): 213-24 (2003)
2007  
103
Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy.
[17011663] Diabetes Res Clin Pract 76(2): 177-86 (2007)
2008  
104
The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.
[17826224] Growth Horm IGF Res 18(1): 17-25 (2008)
2011  
105
Insulin-like growth factor I and the pathogenesis of delirium: a review of current evidence.
[21766035] J Aging Res 2011(-): 951403 (2011)
2010  
106
Downregulation of serum IGF-1 for treatment of early worsening of diabetic retinopathy: a long-term follow-up of two cases.
[19940532] Ophthalmologica 224(4): 243-6 (2010)
2011  
107
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.
[21798082] Skelet Muscle 1(1): 4 (2011)
2008  
108
The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency.
[18359741] Hormones (Athens) 7(1): 24-7 (2008)
2005  
109
Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs.
[15528274] Mol Endocrinol 19(1): 1-11 (2005)
2011  
110
The link between the metabolic syndrome and cancer.
[21912508] Int J Biol Sci 7(7): 1003-15 (2011)
2010  
111
GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.
[20197666] Horm Res Paediatr 73(3): 153-60 (2010)
2006  
112
Genetic disorders in the growth hormone - insulin-like growth factor-I axis.
[16917171] Horm Res 66(5): 221-30 (2006)
2008  
113
Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology.
[18325486] Cell Immunol 252(1-2): 91-110 (2008)
2010  
114
Targeting insulin-like growth factor signaling: rational combination strategies.
[20807783] Mol Cancer Ther 9(9): 2447-9 (2010)
2010  
115
A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.
[21154998] World J Gastroenterol 16(46): 5779-89 (2010)

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  • IGF1

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