suck pdf from google scholar
PDF vom PMID21356169 :   free
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lüll
  • State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors
  • Scartozzi M; Bianconi M; Maccaroni E; Giampieri R; Del Prete M; Berardi R; Cascinu S
  • Discov Med 2011[Feb]; 11 (57): 144-53
  • Insulin-like growth factor receptor 1 (IGF-1R) with its ligands and intracellular pathway is involved in cell growth and survival control. Many studies have shown how IGF-1R is over-expressed in various tumor cell lines and histological samples. In recent years many trials have been conducted investigating IGF-1R as a possible cancer therapy, with major efforts focusing on the use of monoclonal antibodies and small molecules directed against the IGF-1R-driven pathway. Several drugs are currently under intense investigation and in different experimental phases. Available data suggest that this class of drugs is well tolerated with mild to moderate side effects, when used alone or in combination with other therapeutic agents. The efficacy profile seems to be promising. However, further studies are needed to define the exact role of IGF-1R inhibitors in clinical practice.
  • |Animals[MESH]
  • |Antibodies, Monoclonal/adverse effects/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Molecular Targeted Therapy/*trends[MESH]
  • |Neoplasms/*drug therapy/*enzymology[MESH]
  • |Protein Kinase Inhibitors/adverse effects/pharmacology/therapeutic use[MESH]
  • |Receptor, IGF Type 1/*antagonists & inhibitors/metabolism[MESH]
  • |Signal Transduction/drug effects[MESH]





  • *{{pmid21356169}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=21356169 State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors ]</b> Discov Med 2011; 11(57) ; 144-53 Scartozzi M; Bianconi M; Maccaroni E; Giampieri R; Del Prete M; Berardi R; Cascinu S

        *21356169*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Discov Med

    144 57.11 2011