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The IGF system and breast cancer Sachdev D; Yee DEndocr Relat Cancer 2001[Sep]; 8 (3): 197-209The IGF system components have been implicated in breast cancer progression. IGF-I and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.|Breast Neoplasms/*metabolism[MESH]|Female[MESH]|Humans[MESH]|Insulin-Like Growth Factor Binding Proteins/metabolism[MESH]|Insulin-Like Growth Factor I/*metabolism[MESH]|Insulin-Like Growth Factor II/*metabolism[MESH] |