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lüll CSF-1, IGF-1, and the control of postnatal growth and development Gow DJ; Sester DP; Hume DAJ Leukoc Biol 2010[Sep]; 88 (3): 475-81Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic growth and organogenesis. We propose that macrophages are the major extrahepatic source of IGF-1 and that a surge of CSF-1 production contributes to the control of postnatal growth and organ maturation. Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis.|*Growth and Development[MESH]|Animals[MESH]|Humans[MESH]|Insulin-Like Growth Factor I/genetics/*metabolism[MESH]|Macrophage Colony-Stimulating Factor/*metabolism[MESH]|Macrophages/*metabolism[MESH]|Receptor, Macrophage Colony-Stimulating Factor/metabolism[MESH]|Transcription, Genetic[MESH] |