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  • The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
  • Kenyon C
  • Philos Trans R Soc Lond B Biol Sci 2011[Jan]; 366 (1561): 9-16
  • Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
  • |*Mutation[MESH]
  • |Aging/genetics/*physiology[MESH]
  • |Animals[MESH]
  • |Caenorhabditis elegans/genetics/*physiology[MESH]
  • |Insulin-Like Growth Factor I/genetics/*physiology[MESH]
  • |Insulin/genetics/*physiology[MESH]
  • |Signal Transduction[MESH]





  • *{{pmid21115525}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=21115525 The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing ]</b> Philos Trans R Soc Lond B Biol Sci 2011; 366(1561) ; 9-16 Kenyon C

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    Philos Trans R Soc Lond B Biol Sci

    9 1561.366 2011