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  • Cixutumumab
  • McKian KP; Haluska P
  • Expert Opin Investig Drugs 2009[Jul]; 18 (7): 1025-33
  • The IGF pathway plays a major role in cancer cell proliferation, survival and resistance to antineoplastic therapies in many human malignancies. As such, interference with this pathway is the target of many investigational pharmacologic agents. Cixutumumab, a monoclonal antibody to IGF-1R, utilizes this concept. In this review, we summarize preclinical, pharmacologic and early clinical data regarding this agent and discuss the impact this drug might have on the future treatment of human cancers.
  • |Animals[MESH]
  • |Antibodies, Monoclonal/pharmacology/*therapeutic use[MESH]
  • |Antineoplastic Agents/pharmacology/*therapeutic use[MESH]
  • |Clinical Trials as Topic/methods[MESH]
  • |Humans[MESH]
  • |Neoplasms/immunology/therapy[MESH]
  • |Receptor, IGF Type 1/*immunology[MESH]
  • |Signal Transduction/immunology[MESH]

  • *{{pmid19548856}}
    *<b>[ Cixutumumab ]</b> Expert Opin Investig Drugs 2009; 18(7) ; 1025-33 McKian KP; Haluska P


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    Expert Opin Investig Drugs

    1025 7.18 2009