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  • The role of IGF-1R in pediatric malignancies
  • Kim SY; Toretsky JA; Scher D; Helman LJ
  • Oncologist 2009[Jan]; 14 (1): 83-91
  • The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies.
  • |Animals[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Mutation[MESH]
  • |Neoplasms/genetics/*metabolism[MESH]
  • |Receptor, IGF Type 1/genetics/*metabolism[MESH]
  • |Signal Transduction[MESH]

  • *{{pmid19126579}}
    *<b>[ The role of IGF-1R in pediatric malignancies ]</b> Oncologist 2009; 14(1) ; 83-91 Kim SY; Toretsky JA; Scher D; Helman LJ


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    83 1.14 2009