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lüll IGF-1 receptor inhibitors in clinical trials--early lessons Weroha SJ; Haluska PJ Mammary Gland Biol Neoplasia 2008[Dec]; 13 (4): 471-83The insulin-like growth factor pathway plays a major role in cancer cell proliferation, survival and resistance to anti-cancer therapies in many human malignancies, including breast cancer. As a key signaling component of IGF system, the IGF-1 receptor is the target of several investigational agents in clinical and pre-clinical development. This review will focus on the rationale for targeting the IGF-1 receptor and other components of the IGF-1 system. In addition, we will examine the role of IGF-1 signaling in resistance to clinically important breast cancer therapies, including cytotoxic chemotherapy, hormonal therapy and erbB targeted agents. We will also review the completed and ongoing clinical investigations with IGF-1 receptors inhibitors to date and the utility of these early data in designing future breast cancer studies with IGF-1 signaling inhibition strategies.|Animals[MESH]|Antineoplastic Agents/*therapeutic use[MESH]|Clinical Trials as Topic[MESH]|Drug Resistance, Neoplasm/drug effects[MESH]|Humans[MESH]|Neoplasms/drug therapy/enzymology/pathology[MESH]|Protein Kinase Inhibitors/*therapeutic use[MESH]|Receptor, IGF Type 1/*antagonists & inhibitors/metabolism[MESH] |