P53

The p53 family in nervous system development and disease.
[16805769] J Neurochem 97(6): 1571-84 (2006)

TP53 and mutations in human cancer.
[12673364] Acta Biochim Pol 50(1): 231-8 (2003)

The p53-MDM2 network: from oscillations to apoptosis.
[17914240] J Biosci 32(5): 991-7 (2007)

Transcriptional control of the proliferation cluster by the tumor suppressor p53.
[20024063] Mol Biosyst 6(1): 17-29 (2010)

p53 family in development.
[18835440] Mech Dev 125(11-12): 919-31 (2008)

The p53 Pathway Encounters the MicroRNA World.
[19881912] Curr Genomics 10(3): 194-7 (2009)

The role of p53 in apoptosis.
[20193641] Discov Med 9(45): 145-52 (2010)

p53 and its isoforms in cancer.
[17637683] Br J Cancer 97(3): 277-82 (2007)

Targeting the p53-MDM2 interaction to treat cancer.
[15452548] Br J Cancer 91(8): 1415-9 (2004)

Li-Fraumeni syndrome--a molecular and clinical review.
[9218725] Br J Cancer 76(1): 1-14 (1997)

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.
[8123467] Br J Cancer 69(3): 409-16 (1994)

Structural and functional basis for therapeutic modulation of p53 signaling.
[18927276] Clin Cancer Res 14(20): 6376-86 (2008)

Targeting the MDM2-p53 interaction for cancer therapy.
[18765522] Clin Cancer Res 14(17): 5318-24 (2008)

Gain-of-function mutations in the tumor suppressor gene p53.
[10873062] Clin Cancer Res 6(6): 2138-45 (2000)

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.
[8841019] J Natl Cancer Inst 88(20): 1442-55 (1996)

The guardian's little helper: microRNAs in the p53 tumor suppressor network.
[18056431] Cancer Res 67(23): 11099-101 (2007)

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
[8069852] Cancer Res 54(18): 4855-78 (1994)

The p53 family and programmed cell death.
[18955976] Oncogene 27(50): 6507-21 (2008)

Deconstruction of p53 functions and regulation.
[12447685] Oncogene 21(54): 8223-31 (2002)

Loss of p53 and centrosome hyperamplification.
[12214254] Oncogene 21(40): 6234-40 (2002)

p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.
[11571642] Oncogene 20(39): 5449-58 (2001)

The role of tetramerization in p53 function.
[11420672] Oncogene 20(21): 2611-7 (2001)

Regulation of the G2/M transition by p53.
[11313928] Oncogene 20(15): 1803-15 (2001)

Twenty years of p53 research: structural and functional aspects of the p53 protein.
[10618702] Oncogene 18(53): 7621-36 (1999)

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
[10618711] Oncogene 18(53): 7706-17 (1999)

The role of the E6-p53 interaction in the molecular pathogenesis of HPV.
[10618709] Oncogene 18(53): 7690-700 (1999)

Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.
[10618707] Oncogene 18(53): 7676-80 (1999)

Mechanisms of switching on p53: a role for covalent modification?
[10618706] Oncogene 18(53): 7666-75 (1999)

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses.
[10618705] Oncogene 18(53): 7656-65 (1999)

Regulation of p53 in response to DNA damage.
[10618704] Oncogene 18(53): 7644-55 (1999)

Regulation of p53 stability.
[10618703] Oncogene 18(53): 7637-43 (1999)

The cellular response to p53: the decision between life and death.
[10557106] Oncogene 18(45): 6145-57 (1999)

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress.
[9916991] Oncogene 17(25): 3287-99 (1998)

Structural basis for gene activation by p53 family members.
[16294021] Cancer Biol Ther 4(11): 1178-85 (2005)

p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?
[17088261] Carcinogenesis 28(1): 13-20 (2007)

Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications.
[16308315] Carcinogenesis 27(4): 673-81 (2006)

The p53 story: layers of complexity.
[15817608] Carcinogenesis 26(7): 1161-9 (2005)

p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding.
[11375889] Carcinogenesis 22(6): 851-60 (2001)

Targeting p53 for Novel Anticancer Therapy.
[20165689] Transl Oncol 3(1): 1-12 (2010)

Behind the scenes: unravelling the molecular mechanisms of p53 target gene selectivity (Review).
[20878053] Int J Oncol 37(5): 1061-70 (2010)

p53--an acrobat in tumorigenesis.
[9488246] Crit Rev Oral Biol Med 9(1): 23-37 (1998)

p53: the ultimate tumor suppressor gene?
[1397838] FASEB J 6(13): 3169-76 (1992)

Apoptosis - the p53 network.
[12972501] J Cell Sci 116(Pt 20): 4077-85 (2003)

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.
[10769197] J Cell Sci 113 ( Pt 10)(-): 1661-70 (2000)

Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages.
[7919359] Blood 84(8): 2391-411 (1994)

Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo.
[19838055] Cell Cycle 8(21): 3443-4 (2009)

p73 and p63: why do we still need them?
[15254416] Cell Cycle 3(7): 886-94 (2004)

The complexity of p53 stabilization and activation.
[16601750] Cell Death Differ 13(6): 941-50 (2006)

Transcriptional regulation by p53: one protein, many possibilities.
[16575405] Cell Death Differ 13(6): 951-61 (2006)

The P53 pathway: what questions remain to be explored?
[16557269] Cell Death Differ 13(6): 1027-36 (2006)

p53 and disease: when the guardian angel fails.
[16557268] Cell Death Differ 13(6): 1017-26 (2006)

Strategies for therapeutic targeting of the p53 pathway in cancer.
[16557267] Cell Death Differ 13(6): 921-6 (2006)

p53: puzzle and paradigm.
[8654922] Genes Dev 10(9): 1054-72 (1996)

The p53 tumor suppressor protein, a modulator of cell proliferation.
[1639769] J Biol Chem 267(22): 15259-62 (1992)

p53-dependent signal transduction induced by stress.
[9415750] J Radiat Res (Tokyo) 38(3): 179-94 (1997)

p53 enters the microRNA world.
[17996645] Cancer Cell 12(5): 414-8 (2007)

Why is p53 acetylated?
[11779456] Cell 107(7): 815-8 (2001)

Signaling to p53: breaking the MDM2-p53 circuit.
[9778240] Cell 95(1): 5-8 (1998)

Nuclear and mitochondrial apoptotic pathways of p53.
[11286997] FEBS Lett 493(2-3): 65-9 (2001)

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER).
[15665582] Exp Mol Med 36(6): 505-9 (2004)

p53 Induction: phosphorylation sites cooperate in regulating.
[12432278] Cancer Biol Ther 1(3): 284-6 (2002)

Making sense of ubiquitin ligases that regulate p53.
[20930521] Cancer Biol Ther 10(7): 665-72 (2010)

The thousand doors that lead to death: p53-dependent repression and apoptosis.
[14508109] Cancer Biol Ther 2(4): 381-2 (2003)

Restoring p53-dependent tumor suppression.
[14508081] Cancer Biol Ther 2(4 Suppl 1): S55-63 (2003)

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.
[19642417] Nat Prod Rep 26(4): 465-77 (2009)

SIRT1 and p53, effect on cancer, senescence and beyond.
[20471503] Biochim Biophys Acta 1804(8): 1684-9 (2010)

Modulating molecular functions of p53 with small molecules.
[17172837] Cell Cycle 5(22): 2575-8 (2006)

Shifting senescence into quiescence by turning up p53.
[20980826] Cell Cycle 9(21): 4256-7 (2010)

Removing all obstacles: a critical role for p53 in promoting tissue renewal.
[20234190] Cell Cycle 9(7): 1313-9 (2010)

p53 in a crosstalk between DNA repair and cell cycle checkpoints.
[12734432] Cell Cycle 2(3): 233-5 (2003)

Protecting the hedgerow: p53 and hedgehog pathway interactions.
[20081367] Cell Cycle 9(3): 506-11 (2010)

The role of ubiquitination in the direct mitochondrial death program of p53.
[17630506] Cell Cycle 6(14): 1718-23 (2007)

Targeting the p53 family for cancer therapy: 'big brother' joins the fight.
[17721076] Cell Cycle 6(16): 1995-2000 (2007)

Gain of function of p53 cancer mutants in disrupting critical DNA damage response pathways.
[17598983] Cell Cycle 6(13): 1570-3 (2007)

p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas.
[17890905] Cell Cycle 6(18): 2205-9 (2007)

Tiny actors, great roles: microRNAs in p53's service.
[17957137] Cell Cycle 6(21): 2656-61 (2007)

S6-haploinsufficiency activates the p53 tumor suppressor.
[17245121] Cell Cycle 6(1): 20-4 (2007)

p53 induced growth arrest versus apoptosis and its modulation by survival cytokines.
[17264673] Cell Cycle 6(2): 166-70 (2007)

Distinct roles of MDMX in the regulation of p53 response to ribosomal stress.
[17327702] Cell Cycle 6(2): 151-5 (2007)

Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and -34 making the decision?
[19223766] Cell Cycle 8(5): 680-1 (2009)

Recent advances in p53 research and cancer treatment.
[21765642] J Biomed Biotechnol 2011(-): 978312 (2011)

One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.
[21436991] J Biomed Biotechnol 2011(-): 464916 (2011)

Immunological and clinical effects of vaccines targeting p53-overexpressing malignancies.
[21541192] J Biomed Biotechnol 2011(-): 702146 (2011)

Functions of MDMX in the modulation of the p53-response.
[21541195] J Biomed Biotechnol 2011(-): 876173 (2011)

p53: the attractive tumor suppressor in the cancer research field.
[21188172] J Biomed Biotechnol 2011(-): 603925 (2011)

p53-family proteins and their regulators: hubs and spokes in tumor suppression.
[20379196] Cell Death Differ 17(6): 901-11 (2010)

Regulation of p53 responses by post-translational modifications.
[12719715] Cell Death Differ 10(4): 400-3 (2003)

Transcriptional repression mediated by the p53 tumour suppressor.
[12719716] Cell Death Differ 10(4): 404-8 (2003)

Renewing the debate over the p53 apoptotic response.
[12719717] Cell Death Differ 10(4): 409-12 (2003)

Decision making by p53: life, death and cancer.
[12719720] Cell Death Differ 10(4): 431-42 (2003)

p53 stabilization: the importance of nuclear import.
[20062067] Cell Death Differ 17(2): 191-2 (2010)

Mdm2-mediated ubiquitylation: p53 and beyond.
[19498444] Cell Death Differ 17(1): 93-102 (2010)

The multiple levels of regulation by p53 ubiquitination.
[19543236] Cell Death Differ 17(1): 86-92 (2010)

Ubiquitin-independent p53 proteasomal degradation.
[19557012] Cell Death Differ 17(1): 103-8 (2010)

The miR-34 family in cancer and apoptosis.
[19461653] Cell Death Differ 17(2): 193-9 (2010)

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
[17627286] Cell Death Differ 14(9): 1561-75 (2007)

The dark side of a tumor suppressor: anti-apoptotic p53.
[18356920] Cell Death Differ 15(6): 959-76 (2008)

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis.
[19779493] Cell Death Differ 16(12): 1563-72 (2009)

p53: more research and more questions.
[16708075] Cell Death Differ 13(6): 877-80 (2006)

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.
[16601753] Cell Death Differ 13(6): 962-72 (2006)

Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.
[16575406] Cell Death Differ 13(6): 973-83 (2006)

Some p53-binding proteins that can function as arbiters of life and death.
[16575404] Cell Death Differ 13(6): 984-93 (2006)

Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice.
[16557272] Cell Death Differ 13(6): 902-8 (2006)

Sliding into home: facilitated p53 search for targets by the basic DNA binding domain.
[16557271] Cell Death Differ 13(6): 881-4 (2006)

Polymorphic variants in the p53 pathway.
[16557270] Cell Death Differ 13(6): 916-20 (2006)

Lessons from p53 in non-mammalian models.
[16557266] Cell Death Differ 13(6): 909-12 (2006)

Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint.
[16557265] Cell Death Differ 13(6): 898-901 (2006)

p53 in recombination and repair.
[16543940] Cell Death Differ 13(6): 1003-16 (2006)

The functional domains in p53 family proteins exhibit both common and distinct properties.
[16543939] Cell Death Differ 13(6): 890-7 (2006)

Dissecting p53-dependent apoptosis.
[16543937] Cell Death Differ 13(6): 994-1002 (2006)

The versatile interactions of p53 with DNA: when flexibility serves specificity.
[16543936] Cell Death Differ 13(6): 885-9 (2006)

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
[16543935] Cell Death Differ 13(6): 927-34 (2006)

AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer.
[16613876] J Physiol 574(Pt 1): 63-71 (2006)

Potentiating the p53 network.
[20670604] Discov Med 10(50): 94-100 (2010)

The origins and evolution of the p53 family of genes.
[20516129] Cold Spring Harb Perspect Biol 2(6): a001198 (2010)

The tumor suppressor p53: from structures to drug discovery.
[20516128] Cold Spring Harb Perspect Biol 2(6): a000919 (2010)

Single-nucleotide polymorphisms in the p53 signaling pathway.
[20452958] Cold Spring Harb Perspect Biol 2(5): a001032 (2010)

Clinical outcomes and correlates of TP53 mutations and cancer.
[20300207] Cold Spring Harb Perspect Biol 2(3): a001016 (2010)

Tied up in loops: positive and negative autoregulation of p53.
[20452957] Cold Spring Harb Perspect Biol 2(5): a000984 (2010)

The regulation of the p53-mediated stress response by MDM2 and MDM4.
[20182601] Cold Spring Harb Perspect Biol 2(1): a000968 (2010)

TP53 mutations in human cancers: origins, consequences, and clinical use.
[20182602] Cold Spring Harb Perspect Biol 2(1): a001008 (2010)

p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
[20182617] Cold Spring Harb Perspect Biol 2(2): a001057 (2010)

Mutant p53 gain-of-function in cancer.
[20182618] Cold Spring Harb Perspect Biol 2(2): a001107 (2010)

A role for Numb in p53 stabilization.
[18492217] Genome Biol 9(5): 221 (2008)

p53 and its mutants in tumor cell migration and invasion.
[21263025] J Cell Biol 192(2): 209-18 (2011)

The history of p53. A perfect example of the drawbacks of scientific paradigms.
[20930848] EMBO Rep 11(11): 822-6 (2010)

Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.
[20371617] FASEB J 24(8): 2612-9 (2010)

Versatile functions of p53 protein in multicellular organisms.
[18282133] Biochemistry (Mosc) 72(13): 1399-421 (2007)

MDM2 and MDM4: p53 regulators as targets in anticancer therapy.
[17499002] Int J Biochem Cell Biol 39(7-8): 1476-82 (2007)

DRAM links autophagy to p53 and programmed cell death.
[17102582] Autophagy 3(1): 72-4 (2007)

p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells.
[21164280] Cell Adh Migr 5(2): 144-9 (2011)

ASPP: a new family of oncogenes and tumour suppressor genes.
[17211478] Br J Cancer 96(2): 196-200 (2007)

Updates on p53: modulation of p53 degradation as a therapeutic approach.
[18182973] Br J Cancer 98(1): 4-8 (2008)

Jab1 as a mediator of nuclear export and cytoplasmic degradation of p53.
[17085963] Mol Cells 22(2): 133-40 (2006)

Watching the watcher: regulation of p53 by mitochondria.
[19243304] Future Oncol 5(1): 117-30 (2009)

Dangerous habits of a security guard: the two faces of p53 as a drug target.
[17613549] Hum Mol Genet 16 Spec No 1(-): R67-72 (2007)

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.
[20679392] Genes Dev 24(15): 1580-9 (2010)

p53: link to the past, bridge to the future.
[16166374] Genes Dev 19(18): 2091-9 (2005)

Having it both ways: transcription factors that bind DNA and RNA.
[12364590] Nucleic Acids Res 30(19): 4118-26 (2002)

Two faces of p53: aging and tumor suppression.
[17942417] Nucleic Acids Res 35(22): 7475-84 (2007)

The RP-Mdm2-p53 pathway and tumorigenesis.
[21406728] Oncotarget 2(3): 234-8 (2011)

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
[20399660] Trends Cell Biol 20(7): 427-34 (2010)

p53 and ARF: unexpected players in autophagy.
[20303758] Trends Cell Biol 20(6): 363-9 (2010)

The p53 orchestra: Mdm2 and Mdmx set the tone.
[20172729] Trends Cell Biol 20(5): 299-309 (2010)

Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense.
[19101635] Semin Cancer Biol 19(1): 32-41 (2009)

Skp2 and Skp2B team up against Rb and p53.
[21255415] Cell Div 6(1): 1 (2011)

The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response.
[17634135] Cell Div 2(-): 21 (2007)

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models.
[20097732] Carcinogenesis 31(8): 1311-8 (2010)

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention.
[20504879] Carcinogenesis 31(9): 1501-8 (2010)

Complicating the complexity of p53.
[15888490] Carcinogenesis 26(8): 1317-22 (2005)

IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression.
[18941194] J Immunol 181(9): 6051-60 (2008)

The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
[17582219] Cell Cycle 6(11): 1319-23 (2007)

Control of tumor suppressor p53 function by endoplasmic reticulum stress.
[15107622] Cell Cycle 3(5): 567-70 (2004)

Therapeutic targets in the ARF tumor suppressor pathway.
[17627519] Curr Med Chem 14(17): 1815-27 (2007)

Tumor suppression by p53: making cells senescent.
[20183804] Histol Histopathol 25(4): 515-26 (2010)

Protein methylation: a new mechanism of p53 tumor suppressor regulation.
[18581285] Histol Histopathol 23(9): 1143-9 (2008)

Ubiquitin and ubiquitin-like modifications of the p53 family.
[16925948] Neoplasia 8(8): 655-66 (2006)

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc.
[16925946] Neoplasia 8(8): 630-44 (2006)

Running on empty: how p53 controls INS/IGF signaling and affects life span.
[18598747] Exp Gerontol 44(1-2): 93-100 (2009)

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.
[18834305] Annu Rev Pharmacol Toxicol 49(-): 223-41 (2009)

Pathology of hereditary breast cancer.
[21336636] Cell Oncol (Dordr) 34(2): 71-88 (2011)

p53 connects tumorigenesis and reprogramming to pluripotency.
[20876313] J Exp Med 207(10): 2045-8 (2010)

The Role of p53 in Metabolic Regulation.
[21779507] Genes Cancer 2(4): 385-91 (2011)

The Regulation of Aging and Longevity: A New and Complex Role of p53.
[21779512] Genes Cancer 2(4): 443-52 (2011)

p53 Isoforms: An Intracellular Microprocessor?
[21779513] Genes Cancer 2(4): 453-65 (2011)

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
[21779514] Genes Cancer 2(4): 466-74 (2011)

Cytoplasmic functions of the tumour suppressor p53.
[19407794] Nature 458(7242): 1127-30 (2009)

Tumor suppressor p53 meets microRNAs.
[21278451] J Mol Cell Biol 3(1): 44-50 (2011)

p53 RNA interactions: new clues in an old mystery.
[17804642] RNA 13(11): 1825-33 (2007)

Transcriptional targets for pituitary tumor-transforming gene-1.
[19433493] J Mol Endocrinol 43(5): 179-85 (2009)

p53 post-translational modification: deregulated in tumorigenesis.
[20932800] Trends Mol Med 16(11): 528-36 (2010)

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan.
[21431325] J Mol Med (Berl) 89(7): 667-76 (2011)

Metabolic regulation by p53.
[21340684] J Mol Med (Berl) 89(3): 237-45 (2011)

Posttranscriptional regulation of p53 and its targets by RNA-binding proteins.
[19075680] Curr Mol Med 8(8): 845-9 (2008)

New insights into p53 activation.
[20404858] Cell Res 20(6): 614-21 (2010)

p53 and Bad: remote strangers become close friends.
[17404594] Cell Res 17(4): 283-5 (2007)

Axin bridges Daxx to p53.
[17404597] Cell Res 17(4): 301-2 (2007)

Reciprocal influence of the p53 and the hypoxic pathways.
[21614094] Cell Death Dis 2(-): e164 (2011)

p53 and the pathogenesis of skin cancer.
[17270229] Toxicol Appl Pharmacol 224(3): 241-8 (2007)

Constitutive and induced functions of the p53 gene.
[21418001] Biochemistry (Mosc) 75(13): 1692-721 (2010)

The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
[20922462] Cancer Metastasis Rev 29(4): 613-39 (2010)

p53 Research: the past thirty years and the next thirty years.
[20463001] Cold Spring Harb Perspect Biol 2(12): a000893 (2010)

Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy.
[21142860] Future Oncol 6(12): 1857-62 (2010)

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