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Cytoplasmic functions of the tumour suppressor p53 Green DR; Kroemer GNature 2009[Apr]; 458 (7242): 1127-30The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.|Animals[MESH]|Apoptosis[MESH]|Autophagy[MESH]|Cell Nucleus/metabolism[MESH]|Cytoplasm/*metabolism[MESH]|Humans[MESH]|Mitochondria/metabolism[MESH]|Neoplasms/metabolism/pathology[MESH]|Transcription, Genetic[MESH]|Tumor Suppressor Protein p53/genetics/*metabolism[MESH] |
