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lüll The mitochondrial p53 pathway Vaseva AV; Moll UMBiochim Biophys Acta 2009[May]; 1787 (5): 414-20p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field.|*Genes, Tumor Suppressor[MESH]|Apoptosis/genetics[MESH]|Brain Ischemia/pathology[MESH]|Cell Death[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Genes, bcl-2[MESH]|Humans[MESH]|Kidney Diseases/pathology/physiopathology[MESH]|Mitochondria/*physiology[MESH]|Neoplasms/*genetics[MESH]|Protein Transport/physiology[MESH]|Reperfusion Injury/physiopathology[MESH]|Transcription, Genetic[MESH]|Tumor Suppressor Protein p53/genetics/metabolism/*physiology[MESH] |