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lüll SIRT1 and p53, effect on cancer, senescence and beyond Yi J; Luo JBiochim Biophys Acta 2010[Aug]; 1804 (8): 1684-9NAD(+)-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1alpha, NF-kappaB, Ku70 and histones. The first discovered non-histone target of SIRT1, p53, is suggested to play a central role in SIRT1-mediated functions in tumorigenesis and senescence. SIRT1 was originally considered to be a potential tumor promoter since it negatively regulates the tumor suppressor p53 and other tumor suppressors. There is new evidence that SIRT1 acts as a tumor suppressor based on its role in negatively regulating beta-catenin and survivin. This review provides an overview of current knowledge of SIRT1-p53 signaling and controversies regarding the functions of SIRT1 in tumorigenesis.|Aging/*metabolism[MESH]|Animals[MESH]|Apoptosis[MESH]|Cellular Senescence[MESH]|Humans[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasms/etiology/*metabolism[MESH]|Nerve Degeneration/etiology/metabolism[MESH]|Oxidative Stress[MESH]|Signal Transduction[MESH]|Sirtuin 1/*metabolism[MESH]|Tumor Suppressor Protein p53/*metabolism[MESH] |