Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll p53 and disease: when the guardian angel fails Royds JA; Iacopetta BCell Death Differ 2006[Jun]; 13 (6): 1017-26The p53 tumor suppressor gene (TP53) is mutated more often in human cancers than any other gene yet reported. Of importance, it is mutated frequently in the common human malignancies of the breast and colorectum and also, but less frequently, in other significant human cancers such as glioblastomas. There is also one inherited cancer predisposing syndrome called Li-Fraumeni that is caused by TP53 mutations. In this review, we discuss the significance of p53 mutations in some of the above tumors with a view to outlining how p53 contributes to malignant progression. We also discuss the usefulness of TP53 status as a prognostic marker and its role as a predictor of response to therapy. Finally, we outline some evidence that abnormalities in p53 function contribute to the etiology of other non-neoplastic diseases.|Animals[MESH]|Apoptosis[MESH]|Brain Neoplasms/enzymology/*genetics/pathology[MESH]|Breast Neoplasms/genetics/metabolism/pathology[MESH]|Cell Transformation, Neoplastic/*genetics/metabolism/pathology[MESH]|Databases, Genetic[MESH]|Drug Resistance, Neoplasm/genetics[MESH]|Germ-Line Mutation[MESH]|Glioblastoma/enzymology/*genetics/pathology[MESH]|Humans[MESH]|Inflammation/genetics/metabolism[MESH]|Li-Fraumeni Syndrome/*genetics/metabolism[MESH]|Meta-Analysis as Topic[MESH]|Neoplasm Invasiveness[MESH]|Neurodegenerative Diseases/genetics/metabolism[MESH]|Telomerase/metabolism[MESH]|Telomere/metabolism[MESH]|Tumor Suppressor Protein p53/*genetics/metabolism[MESH] |