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lüll The dark side of a tumor suppressor: anti-apoptotic p53 Janicke RU; Sohn D; Schulze-Osthoff KCell Death Differ 2008[Jun]; 15 (6): 959-76Depending on multiple factors DNA damage leads either to cell cycle arrest or apoptosis. One of the main players deciding the fate of a cell is the tumor suppressor p53 that modulates these responses in a transcription-dependent and -independent manner. Over the past few years, however, strong evidence accumulated that p53 engages also powerful pro-survival pathways by transcriptionally activating a multitude of genes whose products efficiently counteract apoptosis. Our review summarizes the current knowledge concerning approximately forty p53-regulated proteins that exert their anti-apoptotic potential by interfering with diverse cellular processes. These activities are surely essential for normal development and maintenance of a healthy organism, but may easily turn into the dark side of the tumor suppressor p53 contributing to tumorigenesis.|Animals[MESH]|Apoptosis[MESH]|Apoptosis Regulatory Proteins/*metabolism[MESH]|Cell Cycle[MESH]|DNA Repair[MESH]|MAP Kinase Signaling System[MESH]|Oxidative Stress[MESH]|Transcription Factors/metabolism[MESH]|Tumor Suppressor Protein p53/*physiology[MESH] |