LE WE PMID CA
HIF1alpha und HIF1 (BASKET)1185HIF1alpha und HIF1 (allg)

Adrenal gland (Neoplasia Pheochromocytoma)

Apoptosis

Asparaginyl hydroxylation

Chuvash polycythemia

CNS (Stroke BASKET)

EglN3 proloyl hydroxylase

Embryology (BASKET)

Endothelin

Epigenetics

Erythrocytes (Erythropoiesis)

Erythropoietin

Extracellular matrix

FIH1

FoxA2

HIF1alpha und HIF1 (BASKET)

HIF2alpha

Histone deacetylase

Histone demethylase

HSP90

Inflammation (BASKET)

Ischemia reperfusion

JMJD1A KDM3A

Kidney (Chronic renal failure)

Kidney (Development)

Kidney (Fibrosis)

Kidney (Microcirculation)

Mitochondria (BASKET)

Morphogenesis (Development)

MTOR

Myc

Neoplasia (Carcinogenesis)

Neoplasia (Tumor biology and immunology)

Nitric oxide NO

Oxygen (Hypoxia)

P53

Paraganglioma

PHD protein domain

PHD2

Prolyl hydroxylases

Prostate (Neoplasia)

RACK1

Radiation therapy

Redox (BASKET)

Remodeling

SDH Succinate dehydrogenase

SIAH2

Sphingosine1 phosphate

Stem cell (Neoplasia)

Tuberculosis

Unfolded protein response

VHL

2002  
1
Oxygen-dependent and -independent regulation of HIF-1alpha.
[12378005] J Korean Med Sci 17(5): 581-8 (2002)
2007  
2
Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.
[18160990] Yale J Biol Med 80(2): 51-60 (2007)
2004  
3
HIF-1: the knowns and unknowns of hypoxia sensing.
[15448722] Acta Biochim Pol 51(3): 563-85 (2004)
2004  
4
Hypoxia inducible factor-1alpha as a cancer drug target.
[15141023] Mol Cancer Ther 3(5): 647-54 (2004)
2005  
5
Targeting hypoxia and angiogenesis through HIF-1alpha inhibition.
[16294030] Cancer Biol Ther 4(10): 1055-62 (2005)
2004  
6
Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade.
[15197355] Cancer Biol Ther 3(6): 503-4 (2004)
2004  
7
HIF-1: an oxygen and metal responsive transcription factor.
[14726713] Cancer Biol Ther 3(1): 29-35 (2004)
2006  
8
Inhibiting hypoxia-inducible factor 1 for cancer therapy.
[16940159] Mol Cancer Res 4(9): 601-5 (2006)
2009  
9
2003  
10
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
[12829734] J Cell Sci 116(Pt 15): 3041-9 (2003)
2006  
11
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.
[16391536] EMBO Rep 7(1): 41-5 (2006)
2004  
12
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.
[15371333] Genes Dev 18(18): 2183-94 (2004)
2003  
13
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.
[14597660] Genes Dev 17(21): 2614-23 (2003)
2000  
14
HIF-1 and human disease: one highly involved factor.
[10950862] Genes Dev 14(16): 1983-91 (2000)
2003  
15
Hypoxia-inducible factor and its biomedical relevance.
[12639949] J Biol Chem 278(22): 19575-8 (2003)
2001  
16
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
[11595178] Cell 107(1): 1-3 (2001)
1999  
17
Perspectives on oxygen sensing.
[10458603] Cell 98(3): 281-4 (1999)
2004  
18
Physiological and pathological responses to hypoxia.
[15161623] Am J Pathol 164(6): 1875-82 (2004)
2002  
19
Oxygen-dependent signaling in pulmonary vascular smooth muscle.
[12225941] Am J Physiol Lung Cell Mol Physiol 283(4): L671-7 (2002)
2006  
20
Hypoxia-inducible factors in the kidney.
[16554418] Am J Physiol Renal Physiol 291(2): F271-81 (2006)
2008  
21
The HIF/VHL pathway: from oxygen sensing to innate immunity.
[17932373] Am J Respir Cell Mol Biol 38(3): 251-5 (2008)
2007  
22
Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps.
[17990984] Biochem J 408(2): e5-6 (2007)
2008  
23
Hypoxia-inducible factor: roles in development, physiology, and disease.
[18345017] Cell Death Differ 15(4): 619-20 (2008)
2008  
24
2008  
25
Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing.
[18591338] Eur Respir J 32(1): 210-7 (2008)
2005  
26
2003  
27
HIF-1: an oxygen response system with special relevance to the kidney.
[14569080] J Am Soc Nephrol 14(11): 2712-22 (2003)
2004  
28
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis.
[15452150] J Clin Pathol 57(10): 1009-14 (2004)
2005  
29
Acute oxygen-sensing mechanisms.
[16282179] N Engl J Med 353(19): 2042-55 (2005)
2005  
30
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
[15831232] Neuro Oncol 7(2): 134-53 (2005)
2002  
31
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology.
[12537605] Respir Res 3(-): 26 (2002)
2004  
32
Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.
[15031665] Exp Mol Med 36(1): 1-12 (2004)
2007  
33
RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
[17361105] Cell Cycle 6(6): 656-9 (2007)
2007  
34
HIF-1-regulated glucose metabolism: a key to apoptosis resistance?
[17404504] Cell Cycle 6(7): 790-2 (2007)
2010  
35
Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.
[20940432] Physiology (Bethesda) 25(5): 272-9 (2010)
2004  
36
Hydroxylation of HIF-1: oxygen sensing at the molecular level.
[15304631] Physiology (Bethesda) 19(-): 176-82 (2004)
2009  
37
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
[19364912] Physiology (Bethesda) 24(-): 97-106 (2009)
2009  
38
HIF in kidney disease and development.
[19118148] J Am Soc Nephrol 20(9): 1877-87 (2009)
2011  
39
Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.
[21151670] J Biomed Biotechnol 2011(-): 197946 (2011)
2010  
40
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
[20164116] Cardiovasc Res 86(2): 236-42 (2010)
2007  
41
Nitric oxide and superoxide: interference with hypoxic signaling.
[17412315] Cardiovasc Res 75(2): 275-82 (2007)
2008  
42
Role and regulation of prolyl hydroxylase domain proteins.
[18259202] Cell Death Differ 15(4): 635-41 (2008)
2008  
43
Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion.
[18259200] Cell Death Differ 15(4): 686-90 (2008)
2008  
44
The role of hypoxia-inducible factors in tumorigenesis.
[18259193] Cell Death Differ 15(4): 678-85 (2008)
2008  
45
Mitochondrial complex III regulates hypoxic activation of HIF.
[18219320] Cell Death Differ 15(4): 660-6 (2008)
2008  
46
The VHL tumor suppressor and HIF: insights from genetic studies in mice.
[18219317] Cell Death Differ 15(4): 650-9 (2008)
2008  
47
Turn me on: regulating HIF transcriptional activity.
[18202699] Cell Death Differ 15(4): 642-9 (2008)
2008  
48
Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation.
[18188166] Cell Death Differ 15(4): 672-7 (2008)
2009  
49
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
[19494350] Blood 114(10): 2015-9 (2009)
2011  
50
Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment.
[21422725] J Pharmacol Sci 115(4): 446-52 (2011)
2011  
51
Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy.
[21422727] J Pharmacol Sci 115(4): 440-5 (2011)
2011  
52
Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.
[21422728] J Pharmacol Sci 115(4): 453-8 (2011)
2004  
53
Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.
[15037806] J Pharmacol Sci 94(3): 221-32 (2004)
2009  
54
Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD.
[19151537] J Pharmacol Sci 109(1): 24-31 (2009)
2003  
55
HIF hydroxylation and the mammalian oxygen-sensing pathway.
[12639980] J Clin Invest 111(6): 779-83 (2003)
2010  
56
HIF-1: upstream and downstream of cancer metabolism.
[19942427] Curr Opin Genet Dev 20(1): 51-6 (2010)
2009  
57
When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
[19383898] Cancer Res 69(9): 3723-6 (2009)
2010  
58
PHD2 in tumour angiogenesis.
[20461086] Br J Cancer 103(1): 1-5 (2010)
2010  
59
Hypoxia inducible factors in cancer stem cells.
[20104230] Br J Cancer 102(5): 789-95 (2010)
2003  
60
Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.
[12603311] Eur J Biochem 270(5): 781-90 (2003)
2003  
61
The subtle side to hypoxia inducible factor (HIFalpha) regulation.
[12603312] Eur J Biochem 270(5): 791-8 (2003)
2004  
62
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.
[14766767] J Appl Physiol 96(3): 1173-7; discussion 1170-2 (2004)
2007  
63
Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.
[17720748] Exp Physiol 92(6): 988-91 (2007)
2010  
64
Inflammation, HIF-1, and the epigenetics that follows.
[21197398] Mediators Inflamm 2010(-): 263914 (2010)
2011  
65
Epigenetics: new questions on the response to hypoxia.
[21845106] Int J Mol Sci 12(7): 4705-21 (2011)
2010  
66
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.
[20061373] Nucleic Acids Res 38(7): 2332-45 (2010)
2008  
67
The role of oxygen availability in embryonic development and stem cell function.
[18285802] Nat Rev Mol Cell Biol 9(4): 285-96 (2008)
2010  
68
Hypoxic regulation of erythropoiesis and iron metabolism.
[20444740] Am J Physiol Renal Physiol 299(1): F1-13 (2010)
2010  
69
The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.
[21037926] Oncotarget 1(5): 379-85 (2010)
2007  
70
Endothelins and hypoxia-inducible factor in cancer.
[17639040] Endocr Relat Cancer 14(2): 233-44 (2007)
2007  
71
Reactive oxygen species and cellular oxygen sensing.
[17893032] Free Radic Biol Med 43(9): 1219-25 (2007)
2009  
72
Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke.
[19903149] Curr Med Chem 16(34): 4593-600 (2009)
2009  
73
Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.
[19671045] Curr Pharm Des 15(33): 3853-60 (2009)
2008  
74
The human side of hypoxia-inducible factor.
[18410568] Br J Haematol 141(3): 325-34 (2008)
2010  
75
SDH-related pheochromocytoma and paraganglioma.
[20833333] Best Pract Res Clin Endocrinol Metab 24(3): 415-24 (2010)
2006  
76
The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.
[16935775] Bull Cancer 93(8): E73-80 (2006)
2004  
77
HIF-1alpha: a valid therapeutic target for tumor therapy.
[20368827] Cancer Res Treat 36(6): 343-53 (2004)
2010  
78
Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.
[20599462] Semin Fetal Neonatal Med 15(4): 196-202 (2010)
2010  
79
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.
[19946328] Oncogene 29(5): 625-34 (2010)
2011  
80
How can we overcome tumor hypoxia in radiation therapy?
[21952313] J Radiat Res (Tokyo) 52(5): 545-56 (2011)
2010  
81
Extracellular matrix genes as hypoxia-inducible targets.
[19662436] Cell Tissue Res 339(1): 19-29 (2010)
2010  
82
Hypoxia-inducible factors and the response to hypoxic stress.
[20965423] Mol Cell 40(2): 294-309 (2010)
2010  
83
Inter-connection between mitochondria and HIFs.
[20158574] J Cell Mol Med 14(4): 795-804 (2010)
2009  
84
Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.
[19691672] J Cell Mol Med 13(10): 4104-12 (2009)
2009  
85
Development of HIF-1 inhibitors for cancer therapy.
[19674190] J Cell Mol Med 13(9A): 2780-6 (2009)
2009  
86
Hypoxia-inducible factors in stem cells and cancer.
[19900215] J Cell Mol Med 13(11-12): 4319-28 (2009)
2008  
87
Hypoxia-induced signaling in the cardiovascular system.
[17850210] Annu Rev Physiol 70(-): 51-71 (2008)
2011  
88
Reciprocal influence of the p53 and the hypoxic pathways.
[21614094] Cell Death Dis 2(-): e164 (2011)
2010  
89
Hypoxia-inducible factors as essential regulators of inflammation.
[20517715] Curr Top Microbiol Immunol 345(-): 105-20 (2010)
2008  
90
Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element.
[18505681] Clin Chim Acta 395(1-2): 6-13 (2008)

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