HIF1alpha und HIF1 (BASKET)

Oxygen-dependent and -independent regulation of HIF-1alpha.
[12378005] J Korean Med Sci 17(5): 581-8 (2002)

Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.
[18160990] Yale J Biol Med 80(2): 51-60 (2007)

HIF-1: the knowns and unknowns of hypoxia sensing.
[15448722] Acta Biochim Pol 51(3): 563-85 (2004)

Hypoxia inducible factor-1alpha as a cancer drug target.
[15141023] Mol Cancer Ther 3(5): 647-54 (2004)

Targeting hypoxia and angiogenesis through HIF-1alpha inhibition.
[16294030] Cancer Biol Ther 4(10): 1055-62 (2005)

Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade.
[15197355] Cancer Biol Ther 3(6): 503-4 (2004)

HIF-1: an oxygen and metal responsive transcription factor.
[14726713] Cancer Biol Ther 3(1): 29-35 (2004)

Inhibiting hypoxia-inducible factor 1 for cancer therapy.
[16940159] Mol Cancer Res 4(9): 601-5 (2006)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
[12829734] J Cell Sci 116(Pt 15): 3041-9 (2003)

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.
[16391536] EMBO Rep 7(1): 41-5 (2006)

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.
[15371333] Genes Dev 18(18): 2183-94 (2004)

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.
[14597660] Genes Dev 17(21): 2614-23 (2003)

HIF-1 and human disease: one highly involved factor.
[10950862] Genes Dev 14(16): 1983-91 (2000)

Hypoxia-inducible factor and its biomedical relevance.
[12639949] J Biol Chem 278(22): 19575-8 (2003)

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
[11595178] Cell 107(1): 1-3 (2001)

Perspectives on oxygen sensing.
[10458603] Cell 98(3): 281-4 (1999)

Physiological and pathological responses to hypoxia.
[15161623] Am J Pathol 164(6): 1875-82 (2004)

Oxygen-dependent signaling in pulmonary vascular smooth muscle.
[12225941] Am J Physiol Lung Cell Mol Physiol 283(4): L671-7 (2002)

Hypoxia-inducible factors in the kidney.
[16554418] Am J Physiol Renal Physiol 291(2): F271-81 (2006)

The HIF/VHL pathway: from oxygen sensing to innate immunity.
[17932373] Am J Respir Cell Mol Biol 38(3): 251-5 (2008)

Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps.
[17990984] Biochem J 408(2): e5-6 (2007)

Hypoxia-inducible factor: roles in development, physiology, and disease.
[18345017] Cell Death Differ 15(4): 619-20 (2008)

Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing.
[18591338] Eur Respir J 32(1): 210-7 (2008)

HIF-1: an oxygen response system with special relevance to the kidney.
[14569080] J Am Soc Nephrol 14(11): 2712-22 (2003)

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis.
[15452150] J Clin Pathol 57(10): 1009-14 (2004)

Acute oxygen-sensing mechanisms.
[16282179] N Engl J Med 353(19): 2042-55 (2005)

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
[15831232] Neuro Oncol 7(2): 134-53 (2005)

Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology.
[12537605] Respir Res 3(-): 26 (2002)

Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.
[15031665] Exp Mol Med 36(1): 1-12 (2004)

RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
[17361105] Cell Cycle 6(6): 656-9 (2007)

HIF-1-regulated glucose metabolism: a key to apoptosis resistance?
[17404504] Cell Cycle 6(7): 790-2 (2007)

Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.
[20940432] Physiology (Bethesda) 25(5): 272-9 (2010)

Hydroxylation of HIF-1: oxygen sensing at the molecular level.
[15304631] Physiology (Bethesda) 19(-): 176-82 (2004)

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
[19364912] Physiology (Bethesda) 24(-): 97-106 (2009)

HIF in kidney disease and development.
[19118148] J Am Soc Nephrol 20(9): 1877-87 (2009)

Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.
[21151670] J Biomed Biotechnol 2011(-): 197946 (2011)

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
[20164116] Cardiovasc Res 86(2): 236-42 (2010)

Nitric oxide and superoxide: interference with hypoxic signaling.
[17412315] Cardiovasc Res 75(2): 275-82 (2007)

Role and regulation of prolyl hydroxylase domain proteins.
[18259202] Cell Death Differ 15(4): 635-41 (2008)

Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion.
[18259200] Cell Death Differ 15(4): 686-90 (2008)

The role of hypoxia-inducible factors in tumorigenesis.
[18259193] Cell Death Differ 15(4): 678-85 (2008)

Mitochondrial complex III regulates hypoxic activation of HIF.
[18219320] Cell Death Differ 15(4): 660-6 (2008)

The VHL tumor suppressor and HIF: insights from genetic studies in mice.
[18219317] Cell Death Differ 15(4): 650-9 (2008)

Turn me on: regulating HIF transcriptional activity.
[18202699] Cell Death Differ 15(4): 642-9 (2008)

Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation.
[18188166] Cell Death Differ 15(4): 672-7 (2008)

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
[19494350] Blood 114(10): 2015-9 (2009)

Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment.
[21422725] J Pharmacol Sci 115(4): 446-52 (2011)

Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy.
[21422727] J Pharmacol Sci 115(4): 440-5 (2011)

Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.
[21422728] J Pharmacol Sci 115(4): 453-8 (2011)

Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.
[15037806] J Pharmacol Sci 94(3): 221-32 (2004)

Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD.
[19151537] J Pharmacol Sci 109(1): 24-31 (2009)

HIF hydroxylation and the mammalian oxygen-sensing pathway.
[12639980] J Clin Invest 111(6): 779-83 (2003)

HIF-1: upstream and downstream of cancer metabolism.
[19942427] Curr Opin Genet Dev 20(1): 51-6 (2010)

When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
[19383898] Cancer Res 69(9): 3723-6 (2009)

PHD2 in tumour angiogenesis.
[20461086] Br J Cancer 103(1): 1-5 (2010)

Hypoxia inducible factors in cancer stem cells.
[20104230] Br J Cancer 102(5): 789-95 (2010)

Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.
[12603311] Eur J Biochem 270(5): 781-90 (2003)

The subtle side to hypoxia inducible factor (HIFalpha) regulation.
[12603312] Eur J Biochem 270(5): 791-8 (2003)

O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.
[14766767] J Appl Physiol 96(3): 1173-7; discussion 1170-2 (2004)

Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.
[17720748] Exp Physiol 92(6): 988-91 (2007)

Inflammation, HIF-1, and the epigenetics that follows.
[21197398] Mediators Inflamm 2010(-): 263914 (2010)

Epigenetics: new questions on the response to hypoxia.
[21845106] Int J Mol Sci 12(7): 4705-21 (2011)

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.
[20061373] Nucleic Acids Res 38(7): 2332-45 (2010)

The role of oxygen availability in embryonic development and stem cell function.
[18285802] Nat Rev Mol Cell Biol 9(4): 285-96 (2008)

Hypoxic regulation of erythropoiesis and iron metabolism.
[20444740] Am J Physiol Renal Physiol 299(1): F1-13 (2010)

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.
[21037926] Oncotarget 1(5): 379-85 (2010)

Endothelins and hypoxia-inducible factor in cancer.
[17639040] Endocr Relat Cancer 14(2): 233-44 (2007)

Reactive oxygen species and cellular oxygen sensing.
[17893032] Free Radic Biol Med 43(9): 1219-25 (2007)

Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke.
[19903149] Curr Med Chem 16(34): 4593-600 (2009)

Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.
[19671045] Curr Pharm Des 15(33): 3853-60 (2009)

The human side of hypoxia-inducible factor.
[18410568] Br J Haematol 141(3): 325-34 (2008)

SDH-related pheochromocytoma and paraganglioma.
[20833333] Best Pract Res Clin Endocrinol Metab 24(3): 415-24 (2010)

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.
[16935775] Bull Cancer 93(8): E73-80 (2006)

HIF-1alpha: a valid therapeutic target for tumor therapy.
[20368827] Cancer Res Treat 36(6): 343-53 (2004)

Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.
[20599462] Semin Fetal Neonatal Med 15(4): 196-202 (2010)

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.
[19946328] Oncogene 29(5): 625-34 (2010)

How can we overcome tumor hypoxia in radiation therapy?
[21952313] J Radiat Res (Tokyo) 52(5): 545-56 (2011)

Extracellular matrix genes as hypoxia-inducible targets.
[19662436] Cell Tissue Res 339(1): 19-29 (2010)

Hypoxia-inducible factors and the response to hypoxic stress.
[20965423] Mol Cell 40(2): 294-309 (2010)

Inter-connection between mitochondria and HIFs.
[20158574] J Cell Mol Med 14(4): 795-804 (2010)

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.
[19691672] J Cell Mol Med 13(10): 4104-12 (2009)

Development of HIF-1 inhibitors for cancer therapy.
[19674190] J Cell Mol Med 13(9A): 2780-6 (2009)

Hypoxia-inducible factors in stem cells and cancer.
[19900215] J Cell Mol Med 13(11-12): 4319-28 (2009)

Hypoxia-induced signaling in the cardiovascular system.
[17850210] Annu Rev Physiol 70(-): 51-71 (2008)

Reciprocal influence of the p53 and the hypoxic pathways.
[21614094] Cell Death Dis 2(-): e164 (2011)

Hypoxia-inducible factors as essential regulators of inflammation.
[20517715] Curr Top Microbiol Immunol 345(-): 105-20 (2010)

Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element.
[18505681] Clin Chim Acta 395(1-2): 6-13 (2008)

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