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lüll Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1 Semenza GLExp Physiol 2007[Nov]; 92 (6): 988-91The regulation of tissue perfusion is a major mechanism by which oxygen homeostasis is maintained. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O(2) in all metazoan species. In mammals, HIF-1 promotes angiogenesis, arteriogenesis and vasculogenesis through the production of multiple angiogenic growth factors in ischaemic tissue and by cell-autonomous effects on endothelial cells and bone marrow-derived angiogenic cells. Administration of viral vectors encoding constitutively active forms of the HIF-1alpha subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease.|Animals[MESH]|Blood Circulation/*physiology[MESH]|Cardiovascular Diseases/physiopathology[MESH]|Disease Models, Animal[MESH]|Homeostasis/*physiology[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1/genetics/*physiology[MESH]|Neovascularization, Physiologic/physiology[MESH]|Oxygen/*metabolism[MESH] |