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lüll Hypoxic regulation of erythropoiesis and iron metabolism Haase VHAm J Physiol Renal Physiol 2010[Jul]; 299 (1): F1-13The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.|*Erythropoiesis/drug effects/genetics[MESH]|Anemia/blood/drug therapy/genetics[MESH]|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism[MESH]|Bone Marrow/metabolism[MESH]|Erythrocytes/drug effects/*metabolism[MESH]|Erythropoietin/biosynthesis/*blood/genetics[MESH]|Gene Expression Regulation[MESH]|Hematinics/therapeutic use[MESH]|Homeostasis[MESH]|Humans[MESH]|Hypoxia/*blood/genetics[MESH]|Iron/*blood[MESH]|Kidney/metabolism[MESH]|Oxygen/*blood[MESH]|Polycythemia/blood/genetics[MESH]|Procollagen-Proline Dioxygenase/genetics/metabolism[MESH]|Protein Processing, Post-Translational[MESH]|Von Hippel-Lindau Tumor Suppressor Protein/blood/genetics[MESH] |