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lüll When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy Ader I; Malavaud B; Cuvillier OCancer Res 2009[May]; 69 (9): 3723-6The reduction in the normal level of tissue oxygen tension or hypoxia is a characteristic of solid tumors that triggers the activation of signaling pathways promoting neovascularization, metastasis, increased tumor growth, and resistance to treatments. The activation of the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) has been identified as the master mechanism of adaptation to hypoxia. In a recent study, we identified the sphingosine kinase 1/sphingosine 1-phosphate (SphK1/S1P) pathway, which elicits various cellular processes including cell proliferation, cell survival, or angiogenesis, as a new modulator of HIF-1alpha activity under hypoxic conditions. Here, we consider how the SphK1/S1P signaling pathway could represent a very important target for therapeutic intervention in cancer.|Animals[MESH]|Cell Hypoxia/physiology[MESH]|Drug Delivery Systems[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1, alpha Subunit/metabolism[MESH]|Lysophospholipids/*metabolism[MESH]|Neoplasms/*drug therapy/*metabolism[MESH]|Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/*metabolism[MESH]|Signal Transduction[MESH]|Sphingosine/*analogs & derivatives/metabolism[MESH] |