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lüll Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Rey S; Semenza GLCardiovasc Res 2010[May]; 86 (2): 236-42The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.|*Neovascularization, Physiologic/drug effects/genetics[MESH]|*Signal Transduction/drug effects/genetics[MESH]|Angiogenesis Inducing Agents/therapeutic use[MESH]|Animals[MESH]|Blood Vessels/drug effects/*metabolism/physiopathology[MESH]|Collateral Circulation[MESH]|Coronary Circulation[MESH]|Disease Models, Animal[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1/genetics/*metabolism[MESH]|Hypoxia/genetics/*metabolism/physiopathology/therapy[MESH]|Ischemia/metabolism/physiopathology/therapy[MESH]|Neoplasms/blood supply/metabolism/therapy[MESH]|Neovascularization, Pathologic/metabolism/physiopathology/therapy[MESH]|Oxygen/metabolism[MESH]|Pulmonary Circulation[MESH]|Retinal Neovascularization/metabolism/physiopathology/therapy[MESH]|Transcriptional Activation[MESH] |