Mechanotransduction

Mechanosignal transduction coupling between endothelial and smooth muscle cells: role of hemodynamic forces.
[18344280] Am J Physiol Cell Physiol 294(3): C659-61 (2008)

Cell mechanics and mechanotransduction: pathways, probes, and physiology.
[15189819] Am J Physiol Cell Physiol 287(1): C1-11 (2004)

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases.
[12900384] Am J Physiol Cell Physiol 285(3): C499-508 (2003)

Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.
[17098825] Am J Physiol Heart Circ Physiol 292(3): H1209-24 (2007)

Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with.
[16951049] Am J Physiol Heart Circ Physiol 292(1): H28-42 (2007)

Reactive oxygen species in mechanotransduction.
[15308497] Am J Physiol Lung Cell Mol Physiol 287(3): L484-5 (2004)

Mechanisms of shear stress transmission and transduction in endothelial cells.
[9676631] Chest 114(1 Suppl): 58S-63S (1998)

Dragging along: the glycocalyx and vascular endothelial cell mechanotransduction.
[18403731] Circ Res 102(7): 747-8 (2008)

Ras, Akt, and mechanotransduction in the cardiac myocyte.
[14670833] Circ Res 93(12): 1179-92 (2003)

Spatial microstimuli in endothelial mechanosignaling.
[12623874] Circ Res 92(4): 359-70 (2003)

Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.
[12433832] Circ Res 91(10): 877-87 (2002)

Mechanical stress mechanisms and the cell. An endothelial paradigm.
[8418981] Circ Res 72(2): 239-45 (1993)

Contraction-excitation feedback in myocardium. Physiological basis and clinical relevance.
[6282491] Circ Res 50(6): 757-66 (1982)

Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis.
[18378856] Hypertension 51(5): 1265-71 (2008)

Sensing tension: recognizing ENaC as a stretch sensor.
[15381680] Hypertension 44(5): 616-7 (2004)

Shear stress and flow-mediated dilation.
[15249545] Hypertension 44(2): 119-20 (2004)

Molecules and mechanisms of mechanotransduction.
[15496654] J Neurosci 24(42): 9220-2 (2004)

Mechanisms of mechanotransduction.
[16399074] Dev Cell 10(1): 11-20 (2006)

Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress.
[16594907] J Intern Med 259(4): 393-400 (2006)

Molecular mechanisms of the vascular responses to haemodynamic forces.
[16594906] J Intern Med 259(4): 381-92 (2006)

Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells.
[16594905] J Intern Med 259(4): 373-80 (2006)

Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage.
[16594904] J Intern Med 259(4): 364-72 (2006)

Endothelial mechanotransduction, nitric oxide and vascular inflammation.
[16594903] J Intern Med 259(4): 351-63 (2006)

Mechanotransduction and the glycocalyx.
[16594902] J Intern Med 259(4): 339-50 (2006)

Redox signalling in vascular responses to shear and stretch.
[16780820] Cardiovasc Res 71(2): 269-79 (2006)

Mast cells feel the strain.
[12062704] Cardiovasc Res 55(1): 13-5 (2002)

Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways.
[10869527] Cardiovasc Res 47(1): 23-37 (2000)

Regulation of cardiovascular collagen synthesis by mechanical load.
[10434993] Cardiovasc Res 42(1): 27-44 (1999)

Physiological and pharmacological role of lysophosphatidic acid as modulator in mechanotransduction.
[11885964] Jpn J Pharmacol 87(3): 171-6 (2001)

Two families of mechanosensitive channel proteins.
[12626684] Microbiol Mol Biol Rev 67(1): 66-85, table of contents (2003)

The shear stress of it all: the cell membrane and mechanochemical transduction.
[17569643] Philos Trans R Soc Lond B Biol Sci 362(1484): 1459-67 (2007)

Responsiveness of vascular endothelium to shear stress: potential role of ion channels and cellular cytoskeleton (review).
[10493972] Int J Mol Med 4(4): 323-32 (1999)

Life on the wire: on tensegrity and force balance in cells.
[16116819] Acta Biomed 76(1): 5-12 (2005)

Transient receptor potential vanilloid 4 channel as an important modulator of chondrocyte mechanotransduction of osmotic loading.
[20583111] Arthritis Rheum 62(10): 2850-1 (2010)

Mechanisms for flow-enhanced cell adhesion.
[18299992] Ann Biomed Eng 36(4): 604-21 (2008)

Lights, camera, actin! The cytoskeleton takes center stage in mechanotransduction. Focus on "Mapping the dynamics of shear stress-induced structural changes in endothelial cells.".
[17928535] Am J Physiol Cell Physiol 293(6): C1771-2 (2007)

Angiotensin II, mechanotransduction, and pulsatile arterial hemodynamics in hypertension.
[19734358] Am J Physiol Heart Circ Physiol 297(5): H1567-75 (2009)

Shear stress and flow-mediated dilation: all shear responses are not created equally.
[19028789] Am J Physiol Heart Circ Physiol 296(1): H31-2 (2009)

A mechanosensory system controls cell shape changes during mitosis.
[17245114] Cell Cycle 6(1): 30-5 (2007)

Stretch-activated ion channels: what are they?
[20134028] Physiology (Bethesda) 25(1): 50-6 (2010)

Deciphering the endothelial shear stress sensor.
[18316496] Circulation 117(9): 1124-6 (2008)

Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells.
[18299513] Circulation 117(8): 1082-9 (2008)

Nuclear shape, mechanics, and mechanotransduction.
[18535268] Circ Res 102(11): 1307-18 (2008)

Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity.
[11744009] Cardiovasc Res 53(1): 9-11 (2002)

Shear stress and the endothelial transport barrier.
[20543206] Cardiovasc Res 87(2): 320-30 (2010)

Sensory reception is an attribute of both primary cilia and motile cilia.
[20144998] J Cell Sci 123(Pt 4): 505-9 (2010)

Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels.
[11706013] J Biol Chem 277(4): 2369-72 (2002)

Sensors, transducers, and effectors that regulate cell size and shape.
[19004817] J Biol Chem 284(11): 6595-9 (2009)

What is the hair cell transduction channel?
[16901942] J Physiol 576(Pt 1): 23-8 (2006)

Localisation of the mechanotransducer channels in mammalian cochlear hair cells provides clues to their gating.
[20026619] J Physiol 588(Pt 5): 765-72 (2010)

eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues.
[19342613] Physiol Rev 89(2): 481-534 (2009)

Neighborly relations: cadherins and mechanotransduction.
[20584914] J Cell Biol 189(7): 1075-7 (2010)

Multi-scale mechanics from molecules to morphogenesis.
[19394436] Int J Biochem Cell Biol 41(11): 2147-62 (2009)

Role of the polycytin-primary cilia complex in bone development and mechanosensing.
[20392267] Ann N Y Acad Sci 1192(-): 410-21 (2010)

Molecular mechanisms of mechanosensing in muscle development.
[19441055] Dev Dyn 238(6): 1526-34 (2009)

Mechanotransduction in development: a growing role for contractility.
[19197330] Nat Rev Mol Cell Biol 10(1): 34-43 (2009)

Mechanotransduction in vascular physiology and atherogenesis.
[19197332] Nat Rev Mol Cell Biol 10(1): 53-62 (2009)

Mechanotransduction gone awry.
[19197333] Nat Rev Mol Cell Biol 10(1): 63-73 (2009)

Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress.
[17127393] Front Biosci 12(-): 1450-62 (2007)

Live cell imaging of mechanotransduction.
[20356874] J R Soc Interface 7 Suppl 3(-): S365-75 (2010)

Mechanosensitivity of ion channels based on protein-lipid interactions.
[20356872] J R Soc Interface 7 Suppl 3(-): S307-20 (2010)

Focal adhesion kinase as a regulator of cell tension in the progression of cancer.
[17928235] Semin Cancer Biol 18(1): 45-52 (2008)

Conformation-regulated mechanosensory control via titin domains in cardiac muscle.
[21347754] Pflugers Arch 462(1): 143-54 (2011)

Cytoskeletal protein kinases: titin and its relations in mechanosensing.
[21416260] Pflugers Arch 462(1): 119-34 (2011)

Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new results.
[12552639] Anat Rec A Discov Mol Cell Evol Biol 271(1): 225-39 (2003)

Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs).
[12494484] Anat Rec A Discov Mol Cell Evol Biol 270(1): 2-10 (2003)

TRP channels in the digestive system.
[20932260] Curr Pharm Biotechnol 12(1): 24-34 (2011)

Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.
[18032552] Am J Physiol Renal Physiol 294(2): F316-25 (2008)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18378772] J Cell Biol 181(1): 143-55 (2008)

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
[19359599] Circ Res 104(9): 1123-30 (2009)

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.
[20725677] Integr Biol (Camb) 2(9): 435-42 (2010)

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.
[21606493] J Biol Chem 286(30): 26277-86 (2011)

Impaired pressure sensation in mice lacking TRPV4.
[12692122] J Biol Chem 278(25): 22664-8 (2003)

TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity.
[15753126] J Cell Biol 168(6): 869-74 (2005)

Mechanotransduction by TRP channels: general concepts and specific role in the vasculature.
[19842065] Cell Biochem Biophys 56(1): 1-18 (2010)

Vertebrate and invertebrate TRPV-like mechanoreceptors.
[12765692] Cell Calcium 33(5-6): 471-8 (2003)

TRPV channels' role in osmotransduction and mechanotransduction.
[17217074] Handb Exp Pharmacol (179): 473-87 (2007)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18443356] J Gen Physiol 131(5): i2 (2008)

TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals.
[15961428] J Physiol 567(Pt 1): 53-8 (2005)

Rat Merkel cells are mechanoreceptors and osmoreceptors.
[19898622] PLoS One 4(11): e7759 (2009)

The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study.
[21784462] J Urol 186(3): 1121-7 (2011)

Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins.
[20836083] Microsc Res Tech 74(5): 457-63 (2011)

The mechanosensitive nature of TRPV channels.
[15909178] Pflugers Arch 451(1): 193-203 (2005)

Osteocytes, mechanosensing and Wnt signaling.
[18280232] Bone 42(4): 606-15 (2008)

Cell mechanics and the cytoskeleton.
[20110992] Nature 463(7280): 485-92 (2010)

Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease.
[19466753] Cell Motil Cytoskeleton 66(8): 618-34 (2009)

Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
[17157345] Toxicon 49(2): 249-70 (2007)

Mechanosensitive channels: insights from continuum-based simulations.
[18787764] Cell Biochem Biophys 52(1): 1-18 (2008)

Tensegrity-based mechanosensing from macro to micro.
[18406455] Prog Biophys Mol Biol 97(2-3): 163-79 (2008)

Wide range scanning probe microscopy for probing mechanical effects on cellular function.
[21471658] Arch Histol Cytol 72(4-5): 235-43 (2009)

Mechanoregulation of gene expression in fibroblasts.
[17331678] Gene 391(1-2): 1-15 (2007)

Integrins and extracellular matrix in mechanotransduction.
[21084386] Cold Spring Harb Perspect Biol 2(12): a005066 (2010)

Micropatterning as a tool to decipher cell morphogenesis and functions.
[21123618] J Cell Sci 123(Pt 24): 4201-13 (2010)

Mechanical stress triggers cardiomyocyte autophagy through angiotensin II type 1 receptor-mediated p38MAP kinase independently of angiotensin II.
[24586922] PLoS One 9(2):e89629 (2014)

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