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lüll Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins Sole-Magdalena A; Revuelta EG; Menenez-Diaz I; Calavia MG; Cobo T; Garcia-Suarez O; Perez-Pinera P; De Carlos F; Cobo J; Vega JAMicrosc Res Tech 2011[May]; 74 (5): 457-63Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa(+) C) superfamily, in particular those belonging to the acid-sensing ion channel (ASIC) family, as well as some members of the transient receptor protein (TRP) channel, function as mechanosensors or may be required for mechanosensation in a diverse range of species and cell types. Therefore, we investigated the putative mechanosensitive function of human odontoblasts using immunohistochemistry to detect ENa(+) C subunits (alpha, beta, and gamma) and ASIC (1, 2, 3, and 4) proteins, as well as TRPV4, in these cells. Positive and specific immunoreactivity in the odontoblast soma and/or processes was detected for all proteins studied except alpha-ENa(+) C. The intensity of immunostaining was high for beta-ENa(+) C and ASIC2, whereas it was low for ASIC1, ASIC3, gamma-ENa(+) C, and TRPV4, being absent for alpha-ENa(+) C and ASIC4. These results suggest that human odontoblasts in situ express proteins related to mechanosensitive channels that probably participate in the mechanisms involved in teeth sensory transmission.|*Gene Expression[MESH]|Acid Sensing Ion Channels[MESH]|Adult[MESH]|Female[MESH]|Fluorescent Antibody Technique[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Male[MESH]|Membrane Proteins/*biosynthesis[MESH]|Microscopy[MESH]|Middle Aged[MESH]|Nerve Tissue Proteins/*biosynthesis[MESH]|Odontoblasts/*metabolism[MESH]|Sodium Channels/*biosynthesis[MESH]|TRPV Cation Channels/*biosynthesis[MESH] |