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Mechanisms of mechanotransduction Orr AW; Helmke BP; Blackman BR; Schwartz MADev Cell 2006[Jan]; 10 (1): 11-20Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.|Adaptation, Physiological/*physiology[MESH]|Animals[MESH]|Cell Cycle/physiology[MESH]|Humans[MESH]|Hypertension/pathology/physiopathology[MESH]|Lung/physiology[MESH]|Mechanotransduction, Cellular/*physiology[MESH]|Models, Biological[MESH]|Muscle, Smooth, Vascular/physiopathology[MESH]|Myocardium[MESH]|Neoplasms/physiopathology[MESH]|Physical Stimulation[MESH]|Protein Structure, Tertiary/physiology[MESH]|Signal Transduction/*physiology[MESH]|Stress, Mechanical[MESH] |
