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Mechanisms for flow-enhanced cell adhesion Zhu C; Yago T; Lou J; Zarnitsyna VI; McEver RPAnn Biomed Eng 2008[Apr]; 36 (4): 604-21Cell adhesion is mediated by specific receptor-ligand bonds. In several biological systems, increasing flow has been observed to enhance cell adhesion despite the increasing dislodging fluid shear forces. Flow-enhanced cell adhesion includes several aspects: flow augments the initial tethering of flowing cells to a stationary surface, slows the velocity and increases the regularity of rolling cells, and increases the number of rollingly adherent cells. Mechanisms for this intriguing phenomenon may include transport-dependent acceleration of bond formation and force-dependent deceleration of bond dissociation. The former includes three distinct transport modes: sliding of cell bottom on the surface, Brownian motion of the cell, and rotational diffusion of the interacting molecules. The latter involves a recently demonstrated counterintuitive behavior called catch bonds where force prolongs rather than shortens the lifetimes of receptor-ligand bonds. In this article, we summarize our recently published data that used dimensional analysis and mutational analysis to elucidate the above mechanisms for flow-enhanced leukocyte adhesion mediated by L-selectin-ligand interactions.|*Models, Cardiovascular[MESH]|Animals[MESH]|Blood Flow Velocity/*physiology[MESH]|Blood Pressure/*physiology[MESH]|Cell Adhesion/*physiology[MESH]|Cell Movement[MESH]|Computer Simulation[MESH]|Humans[MESH]|Leukocytes/*physiology[MESH]|Mechanotransduction, Cellular/*physiology[MESH]|Shear Strength[MESH] |
