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lüll Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology Bowman CL; Gottlieb PA; Suchyna TM; Murphy YK; Sachs FToxicon 2007[Feb]; 49 (2): 249-70Sensing the energy from mechanical inputs is ubiquitous--and perhaps the oldest form of biological energy transduction. However, the tools available to probe the mechanisms of transduction are far fewer than for the chemical and electric field sensitive transducers. The one pharmacological tool available for mechansensitive ion channels (MSCs) is a peptide (GsMTx-4) isolated from venom of the tarantula, Grammostola spatulata, that blocks cationic MSCs found in non-specialized eukaryotic tissues. In this review, we summarize the current knowledge of GsMTx-4, and discuss the inevitable crosstalk between the MSC behavior and the mechanical properties of the cell cortex.|*Ion Channel Gating/drug effects/physiology[MESH]|Animals[MESH]|Base Sequence[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins[MESH]|Molecular Sequence Data[MESH]|Peptides/chemistry/genetics/*pharmacology[MESH]|Spider Venoms/chemistry/genetics/*pharmacology[MESH]|Structure-Activity Relationship[MESH] |