TRPV1

The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor.
[18806809] Br J Pharmacol 155(8): 1145-62 (2008)

Vanilloid (capsaicin) receptors in health and disease.
[12109845] Am J Clin Pathol 118(1): 110-21 (2002)

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
[19074743] Physiology (Bethesda) 23(-): 360-70 (2008)

Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target?
[18606896] Hypertension 52(2): 213-4 (2008)

Biochemical pharmacology of the vanilloid receptor TRPV1. An update.
[15128291] Eur J Biochem 271(10): 1814-9 (2004)

Molecular architecture of the vanilloid receptor. Insights for drug design.
[15128292] Eur J Biochem 271(10): 1820-6 (2004)

Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels.
[15128293] Eur J Biochem 271(10): 1827-34 (2004)

Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.
[18481914] Physiol Res 57 Suppl 3(-): S59-68 (2008)

The role of spinal cord vanilloid (TRPV1) receptors in pain modulation.
[18481913] Physiol Res 57 Suppl 3(-): S69-77 (2008)

Role of TRPV1 in inflammation-induced airway hypersensitivity.
[19269247] Curr Opin Pharmacol 9(3): 243-9 (2009)

Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.
[21949157] Am J Physiol Lung Cell Mol Physiol 302(1): L111-9 (2012)

TRP channels in the digestive system.
[20932260] Curr Pharm Biotechnol 12(1): 24-34 (2011)

Homo- and heteromeric assembly of TRPV channel subunits.
[15713749] J Cell Sci 118(Pt 5): 917-28 (2005)

Pharmacology of vanilloid transient receptor potential cation channels.
[19297520] Mol Pharmacol 75(6): 1262-79 (2009)

Vanilloid transient receptor potential cation channels: an overview.
[18220815] Curr Pharm Des 14(1): 18-31 (2008)

N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.
[18567714] Am J Physiol Heart Circ Physiol 295(2): H728-35 (2008)

TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.
[17586621] Am J Physiol Heart Circ Physiol 293(3): H1791-8 (2007)

Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse.
[17237150] Am J Physiol Lung Cell Mol Physiol 292(5): L1173-81 (2007)

Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors.
[19812353] Am J Physiol Regul Integr Comp Physiol 297(6): R1681-90 (2009)

TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.
[18337316] Am J Physiol Regul Integr Comp Physiol 294(5): R1517-23 (2008)

Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?
[19692481] Am J Physiol Renal Physiol 297(5): F1427-34 (2009)

Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.
[18032552] Am J Physiol Renal Physiol 294(2): F316-25 (2008)

Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.
[21383614] Anesthesiology 114(5): 1190-9 (2011)

Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition.
[21232043] Br J Pharmacol 163(2): 330-45 (2011)

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.
[16107881] EMBO J 24(17): 3026-37 (2005)

TRPV1-null mice are protected from diet-induced obesity.
[18503767] FEBS Lett 582(15): 2257-62 (2008)

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain.
[18252749] Gut 57(7): 923-9 (2008)

Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.
[19858408] Hypertension 54(6): 1298-305 (2009)

Segmental regulation of sodium and water excretion by TRPV1 activation in the kidney.
[18398380] J Cardiovasc Pharmacol 51(5): 437-42 (2008)

Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa.
[21103419] J Neurogastroenterol Motil 16(4): 374-88 (2010)

TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.
[17065246] J Neurophysiol 97(1): 503-11 (2007)

Dual regulation of TRPV1 by phosphoinositides.
[17596456] J Neurosci 27(26): 7070-80 (2007)

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
[17329430] J Neurosci 27(9): 2331-7 (2007)

Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro.
[15659603] J Neurosci 25(3): 662-71 (2005)

Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors.
[16284279] J Pharmacol Exp Ther 316(3): 969-82 (2006)

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
[15837818] J Pharmacol Exp Ther 314(1): 410-21 (2005)

Transient receptor potential vanilloid 1 - a polymodal nociceptive receptor - plays a crucial role in formaldehyde-induced skin inflammation in mice.
[22302023] J Pharmacol Sci 118(2): 266-74 (2012)

Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans.
[20807792] J Physiol 588(Pt 21): 4317-26 (2010)

Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-beta/Smad signaling in DOCA-salt hypertension.
[21792478] Mol Med 17(11-12): 1204-12 (2011)

Phospholipase C mediated modulation of TRPV1 channels.
[18528787] Mol Neurobiol 37(2-3): 153-63 (2008)

Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1.
[18256211] Mol Pharmacol 73(5): 1405-12 (2008)

Protective role of palmitoylethanolamide in contact allergic dermatitis.
[19909294] Allergy 65(6): 698-711 (2010)

TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.
[17717412] Am J Nephrol 27(5): 530-7 (2007)

Pore helix domain is critical to camphor sensitivity of transient receptor potential vanilloid 1 channel.
[22314297] Anesthesiology 116(4): 903-17 (2012)

Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases.
[22477184] Arch Pharm Res 35(3): 393-6 (2012)

Increased transient receptor potential vanilloid type 1 (TRPV1) channel expression in hypertrophic heart.
[20833132] Biochem Biophys Res Commun 401(1): 98-103 (2010)

Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells.
[19196257] Clin Exp Pharmacol Physiol 36(1): 77-83 (2009)

Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.
[21846804] Endocrinology 152(10): 3811-9 (2011)

Vasorelaxation to capsaicin and its effects on calcium influx in arteries.
[22532967] Eur J Pharmacol 681(1-3): 88-93 (2012)

Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
[20826151] Eur J Pharmacol 647(1-3): 75-83 (2010)

Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo.
[19161409] Exp Dermatol 18(5): 431-6 (2009)

Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia.
[22722616] Gut (): (2012)

Expression of transient receptor potential vanilloid-1 (TRPV1) in urothelial cancers of human bladder: relation to clinicopathological and molecular parameters.
[21083604] Histopathology 57(5): 744-52 (2010)

Transient receptor potential vanilloid type 1 channels contribute to reflex cutaneous vasodilation in humans.
[22518827] J Appl Physiol 112(12): 2037-42 (2012)

TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery.
[21345654] J Dermatol Sci 62(1): 8-15 (2011)

TRPV1 deletion enhances local inflammation and accelerates the onset of systemic inflammatory response syndrome.
[22547700] J Immunol 188(11): 5741-51 (2012)

TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits.
[20950828] J Surg Res 173(1): 153-60 (2012)

Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins.
[20638226] J Vasc Surg 52(5): 1310-20 (2010)

Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels.
[15936040] Life Sci 77(14): 1651-66 (2005)

Reduction of TRPV1 expression in the trigeminal system by botulinum neurotoxin type-A.
[22820141] Neurobiol Dis 48(3): 367-378 (2012)

TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice.
[22395410] Pflugers Arch 463(5): 727-32 (2012)

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.
[22634607] Pharmacol Res 66(3): 243-50 (2012)

The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
[20138997] Pharmacol Res 61(6): 537-46 (2010)

Biochemistry and pharmacology of endovanilloids.
[17349697] Pharmacol Ther 114(1): 13-33 (2007)

TRPV channels and vascular function.
[21062421] Acta Physiol (Oxf) 203(1): 99-116 (2011)

Acid sensing by visceral afferent neurones.
[20456281] Acta Physiol (Oxf) 201(1): 63-75 (2011)

Neurophysiological characterization of mammalian osmosensitive neurones.
[17350993] Exp Physiol 92(3): 499-505 (2007)

Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
[19864432] J Biol Chem 285(1): 731-40 (2010)

A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration.
[17184838] Cell Calcium 42(1): 17-25 (2007)

The transient receptor potential vanilloid-responsive 1 and 4 cation channels: role in neuronal osmosensing and renal physiology.
[17693761] Curr Opin Nephrol Hypertens 16(5): 451-8 (2007)

Acid-sensitive ion channels and receptors.
[19655111] Handb Exp Pharmacol (194): 283-332 (2009)

Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception.
[20935279] J Dent Res 89(12): 1455-60 (2010)

Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder.
[19029406] J Histochem Cytochem 57(3): 277-87 (2009)

Effects of skin surface temperature on epidermal permeability barrier homeostasis.
[17068482] J Invest Dermatol 127(3): 654-9 (2007)

Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.
[21994383] J Neurosci 31(41): 14669-76 (2011)

Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect.
[21098091] J Pharmacol Exp Ther 336(3): 743-50 (2011)

Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.
[16081483] J Physiol 568(Pt 2): 539-51 (2005)

Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes.
[19695100] Mol Pain 5(): 49 (2009)

Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.
[17959775] Proc Natl Acad Sci U S A 104(44): 17524-9 (2007)

Physiopathology of hereditary polyuric states: a molecular view of renal function.
[22802123] Swiss Med Wkly 142(): w13613 (2012)

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia.
[19070372] Trends Pharmacol Sci 30(2): 79-84 (2009)

Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.
[12573376] Lancet 361(9355): 385-91 (2003)

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.
[22820913] Pflugers Arch 464(3): 261-72 (2012)

Inflammatory pain: the cellular basis of heat hyperalgesia.
[18615146] Curr Neuropharmacol 4(3): 197-206 (2006)

Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.
[23221478] Channels (Austin) 7(1):17-22 (2013)

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