Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
TRPV1-null mice are protected from diet-induced obesity Motter AL; Ahern GPFEBS Lett 2008[Jun]; 582 (15): 2257-62We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild-type and TRPV1-null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1-null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild-type and TRPV1-null mice were approximately 51 and 34g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1-null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3-L1 preadipocytes expressed functional calcitonin gene-related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism.|3T3-L1 Cells[MESH]|Adipocytes/*metabolism[MESH]|Adipose Tissue/metabolism/pathology[MESH]|Adiposity/*genetics[MESH]|Animals[MESH]|Body Weight/*genetics[MESH]|Calcitonin Gene-Related Peptide/metabolism[MESH]|Diet[MESH]|Dietary Fats/administration & dosage[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Obesity/*genetics/pathology[MESH]|Peripheral Nerves/metabolism/physiology[MESH]|TRPV Cation Channels/genetics/*physiology[MESH]|Thermogenesis/genetics[MESH] |
