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lüll Transient receptor potential vanilloid type 1 channels contribute to reflex cutaneous vasodilation in humans Wong BJ; Fieger SMJ Appl Physiol (1985) 2012[Jun]; 112 (12): 2037-42Mechanisms underlying the cutaneous vasodilation in response to an increase in core temperature remain unresolved. The purpose of this study was to determine a potential contribution of transient receptor potential vanilloid type 1 (TRPV-1) channels to reflex cutaneous vasodilation. Twelve subjects were equipped with four microdialysis fibers on the ventral forearm, and each site randomly received 1) 90% propylene glycol + 10% lactated Ringer (vehicle control); 2) 10 mM l-NAME; 3) 20 mM capsazepine to inhibit TRPV-1 channels; 4) combined 10 mM l-NAME + 20 mM capsazepine. Whole body heating was achieved via water-perfused suits sufficient to raise oral temperature at least 0.8 degrees C above baseline. Maximal skin blood flow was achieved by local heating to 43 degrees C and infusion of 28 mM nitroprusside. Systemic arterial pressure (SAP) was measured, and skin blood flow was monitored via laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was calculated as LDF/SAP and normalized to maximal vasodilation (%CVC(max)). Capsazepine sites were significantly reduced compared with control (50 +/- 4%CVC(max) vs. 67 +/- 5%CVC(max), respectively; P < 0.05). l-NAME (33 +/- 3%CVC(max)) and l-NAME + capsazepine (30 +/- 4%CVC(max)) sites were attenuated compared with control (P < 0.01) and capsazepine (P < 0.05); however, there was no difference between l-NAME and combined l-NAME + capsazepine. These data suggest TRPV-1 channels participate in reflex cutaneous vasodilation and TRPV-1 channels may account for a portion of the NO component. TRPV-1 channels may have a direct neural contribution or have an indirect effect via increased arterial blood temperature. Whether the TRPV-1 channels directly or indirectly contribute to reflex cutaneous vasodilation remains uncertain.|Adult[MESH]|Blood Pressure/drug effects/physiology[MESH]|Body Temperature/drug effects/physiology[MESH]|Capsaicin/analogs & derivatives/pharmacology[MESH]|Female[MESH]|Forearm/blood supply/physiology[MESH]|Heating/methods[MESH]|Humans[MESH]|Male[MESH]|Microdialysis/methods[MESH]|NG-Nitroarginine Methyl Ester/pharmacology[MESH]|Nitric Oxide/metabolism[MESH]|Nitroprusside/pharmacology[MESH]|Reflex/drug effects/*physiology[MESH]|Regional Blood Flow/drug effects[MESH]|Skin/*blood supply/drug effects/metabolism[MESH]|TRPV Cation Channels/*metabolism[MESH]|Vasodilation/drug effects/physiology[MESH]|Young Adult[MESH] |