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Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice Horton JS; Buckley CL; Stokes AJChannels (Austin) 2013[Jan]; 7 (1): 17-22Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.|Animals[MESH]|Apoptosis/drug effects[MESH]|Cardiomegaly/*drug therapy/genetics/metabolism/physiopathology[MESH]|Disease Models, Animal[MESH]|Heart Failure/*drug therapy/genetics/metabolism/physiopathology[MESH]|Humans[MESH]|Male[MESH]|Matrix Metalloproteinase 9/genetics/metabolism[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Natriuretic Peptide, Brain/genetics/metabolism[MESH]|Pyrazines/*administration & dosage[MESH]|Pyridines/*administration & dosage[MESH]|TRPV Cation Channels/*antagonists & inhibitors[MESH] |
