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Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception Ryu JJ; Yoo S; Kim KY; Park JS; Bang S; Lee SH; Yang TJ; Cho H; Hwang SWJ Dent Res 2010[Dec]; 89 (12): 1455-60Er,Cr:YSGG lasers are used clinically in dentistry. The advantages of laser therapy include minimal thermal damage and the alleviation of pain. This study examined whether the Er,Cr:YSGG laser has in vivo and in vitro antinociceptive effects in itself. In capsaicin-evoked acute licking/shaking tests and Hargreaves tests, laser irradiation with an aerated water spray suppressed nociceptive behavior in mice. Laser irradiation attenuated TRPV1 activation by capsaicin in Ca(2+) imaging experiments with TRPV1-overexpressing cells and cultured trigeminal neurons. Therefore, the laser-induced behavioral changes are probably due to the loss of TRPV1 activity. TRPV4 activity was also attenuated, but limited mechanical antinociception by the laser was observed. The laser failed to alter the other receptor functions, which indicates that the antinociceptive effect of the laser is dependent on TRPV1. These results suggest that the Er,Cr:YSGG laser has analgesic effects via TRPV1 inhibition. Such mechanistic approaches may help define the laser-sensitive pain modality and increase its beneficial uses.|Animals[MESH]|Behavior, Animal/drug effects/radiation effects[MESH]|Calcium Channel Blockers/pharmacology[MESH]|Calcium Signaling/drug effects/radiation effects[MESH]|Capsaicin/pharmacology[MESH]|Dinoprostone/pharmacology[MESH]|HEK293 Cells[MESH]|HeLa Cells[MESH]|Hot Temperature[MESH]|Humans[MESH]|Lasers, Solid-State/*therapeutic use[MESH]|Male[MESH]|Mice[MESH]|Mice, Inbred ICR[MESH]|Mice, Knockout[MESH]|Neurons/drug effects/radiation effects[MESH]|Nociceptors/drug effects/*radiation effects[MESH]|Pain Threshold/radiation effects[MESH]|Pain/*prevention & control[MESH]|Reaction Time/radiation effects[MESH]|Ruthenium Red/pharmacology[MESH]|Sensory System Agents/pharmacology[MESH]|Sensory Thresholds/radiation effects[MESH]|TRPV Cation Channels/drug effects/*radiation effects[MESH]|Thermosensing/radiation effects[MESH]|Touch/radiation effects[MESH]|Trigeminal Nerve/drug effects/radiation effects[MESH] |
