Ubiquitin

Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.
[20109157] Cell Microbiol 12(4): 424-31 (2010)

How microbes utilize host ubiquitination.
[19523153] Cell Microbiol 11(10): 1425-34 (2009)

The enzymes in ubiquitin-like post-translational modifications.
[20103862] Biosci Trends 1(1): 16-25 (2007)

The ubiquitin system, disease, and drug discovery.
[19007437] BMC Biochem 9 Suppl 1(-): S7 (2008)

Deubiquitylating enzymes and disease.
[19007433] BMC Biochem 9 Suppl 1(-): S3 (2008)

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.
[18047746] BMC Biochem 8 Suppl 1(-): S9 (2007)

Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting.
[18047744] BMC Biochem 8 Suppl 1(-): S7 (2007)

Ubiquitin domain proteins in disease.
[18047733] BMC Biochem 8 Suppl 1(-): S1 (2007)

E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation.
[15882441] Traffic 6(6): 429-41 (2005)

Structures of proteases for ubiqutin and ubiquitin-like modifiers.
[18593526] BMB Rep 41(6): 435-43 (2008)

Role of ubiquitylation in cellular membrane transport.
[16601271] Physiol Rev 86(2): 669-707 (2006)

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
[11917093] Physiol Rev 82(2): 373-428 (2002)

Pathways of ubiquitin conjugation.
[9409544] FASEB J 11(14): 1257-68 (1997)

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.
[9409543] FASEB J 11(14): 1245-56 (1997)

Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins.
[9409540] FASEB J 11(14): 1215-26 (1997)

Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs.
[17287393] J Cell Sci 120(Pt 4): 543-53 (2007)

Ubiquitylation and cell signaling.
[16148945] EMBO J 24(19): 3353-9 (2005)

The ubiquitin-proteasome pathway: on protein death and cell life.
[9857172] EMBO J 17(24): 7151-60 (1998)

The ubiquitin-proteasome system in cardiac physiology and pathology.
[16501026] Am J Physiol Heart Circ Physiol 291(1): H1-H19 (2006)

Narrative review: protein degradation and human diseases: the ubiquitin connection.
[17088581] Ann Intern Med 145(9): 676-84 (2006)

Protein partners of deubiquitinating enzymes.
[18687060] Biochem J 414(2): 161-75 (2008)

Ubiquitin-binding domains.
[17034365] Biochem J 399(3): 361-72 (2006)

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
[16212556] Biochem J 391(Pt 2): 153-66 (2005)

Getting into position: the catalytic mechanisms of protein ubiquitylation.
[14998368] Biochem J 379(Pt 3): 513-25 (2004)

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.
[16094395] Cell Death Differ 12(9): 1191-7 (2005)

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
[16094394] Cell Death Differ 12(9): 1178-90 (2005)

Discovery of the ubiquitin proteasome system and its involvement in apoptosis.
[16094390] Cell Death Differ 12(9): 1155-7 (2005)

The role of the ubiquitin-proteasome pathway in apoptosis.
[10381632] Cell Death Differ 6(4): 303-13 (1999)

Cullin-RING ubiquitin ligases: global regulation and activation cycles.
[18282298] Cell Div 3(-): 7 (2008)

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
[16816126] Exp Biol Med (Maywood) 231(7): 1197-211 (2006)

Ubiquitin-mediated degradation of cellular proteins: why destruction is essential for construction, and how it got from the test tube to the patient's bed.
[11411194] Isr Med Assoc J 3(5): 319-27 (2001)

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
[16738015] J Am Soc Nephrol 17(7): 1807-19 (2006)

Non-traditional functions of ubiquitin and ubiquitin-binding proteins.
[12860974] J Biol Chem 278(38): 35857-60 (2003)

The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
[18598940] Cancer Cell 14(1): 10-21 (2008)

A genomic and functional inventory of deubiquitinating enzymes.
[16325574] Cell 123(5): 773-86 (2005)

Back to the future with ubiquitin.
[14744430] Cell 116(2): 181-90 (2004)

RING finger proteins: mediators of ubiquitin ligase activity.
[11007473] Cell 102(5): 549-52 (2000)

Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins.
[17643365] Mol Cell 27(2): 174-5 (2007)

Conjugation and deconjugation of ubiquitin regulating the destiny of proteins.
[12642897] Exp Mol Med 35(1): 1-7 (2003)

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.
[20930542] Cancer Biol Ther 10(8): 737-47 (2010)

Targeting E3 ubiquitin ligases for cancer therapy.
[14688465] Cancer Biol Ther 2(6): 623-9 (2003)

Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor.
[15908780] Cancer Biol Ther 4(5): 506-8 (2005)

The ubiquitin proteasome system in neuropathology.
[19597829] Acta Neuropathol 118(3): 329-47 (2009)

Structural assembly of cullin-RING ubiquitin ligase complexes.
[20880695] Curr Opin Struct Biol 20(6): 714-21 (2010)

Structural regulation of cullin-RING ubiquitin ligase complexes.
[21288713] Curr Opin Struct Biol 21(2): 257-64 (2011)

Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.
[17919899] Curr Opin Struct Biol 17(6): 726-35 (2007)

Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease.
[18723090] Biochim Biophys Acta 1782(12): 795-9 (2008)

The ubiquitin-proteasome system in spongiform degenerative disorders.
[18790052] Biochim Biophys Acta 1782(12): 700-12 (2008)

Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.
[18586085] Biochim Biophys Acta 1782(12): 785-94 (2008)

Roles of ubiquitination at the synapse.
[18222124] Biochim Biophys Acta 1779(8): 495-506 (2008)

The various roles of ubiquitin in Wnt pathway regulation.
[20930545] Cell Cycle 9(18): 3700-9 (2010)

CRL4Cdt2: master coordinator of cell cycle progression and genome stability.
[21212733] Cell Cycle 10(2): 241-9 (2011)

Nuclear effects of ethanol-induced proteasome inhibition in liver cells.
[19291815] World J Gastroenterol 15(10): 1163-7 (2009)

Ubiquitylation of ion channels.
[16287989] Physiology (Bethesda) 20(-): 398-407 (2005)

Ubiquitin and ubiquitin-like proteins in protein regulation.
[17495234] Circ Res 100(9): 1276-91 (2007)

Ubiquitin, a novel paracrine messenger of cardiac cell survival.
[20100704] Cardiovasc Res 86(1): 1-3 (2010)

Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.
[18684710] J Biol Chem 284(13): 8211-5 (2009)

Polyubiquitin chains: functions, structures, and mechanisms.
[18438605] Cell Mol Life Sci 65(15): 2397-406 (2008)

Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.
[19468686] Cell Mol Life Sci 66(17): 2819-33 (2009)

Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases.
[21710433] Int J Dev Biol 55(3): 249-60 (2011)

Linear polyubiquitination: a new regulator of NF-kappaB activation.
[19543231] EMBO Rep 10(7): 706-13 (2009)

The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling.
[16113643] EMBO Rep 6(9): 815-20 (2005)

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.
[19940261] FASEB J 24(4): 981-93 (2010)

Roles of E3 ubiquitin ligases in cell adhesion and migration.
[20009572] Cell Adh Migr 4(1): 10-8 (2010)

Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.
[19887490] Clin Cancer Res 15(22): 6751-7 (2009)

E2s: structurally economical and functionally replete.
[21158740] Biochem J 433(1): 31-42 (2011)

Deubiquitinating enzymes as novel anticancer targets.
[17381419] Future Oncol 3(2): 191-9 (2007)

Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms.
[17609522] Mol Interv 7(3): 157-67 (2007)

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.
[19352404] Nat Rev Mol Cell Biol 10(5): 319-31 (2009)

Diversity of degradation signals in the ubiquitin-proteasome system.
[18698327] Nat Rev Mol Cell Biol 9(9): 679-90 (2008)

CRL4s: the CUL4-RING E3 ubiquitin ligases.
[19818632] Trends Biochem Sci 34(11): 562-70 (2009)

Polyubiquitin binding and disassembly by deubiquitinating enzymes.
[19243136] Chem Rev 109(4): 1495-508 (2009)

Ubiquitin in NF-kappaB signaling.
[19281271] Chem Rev 109(4): 1549-60 (2009)

Viral and cellular MARCH ubiquitin ligases and cancer.
[18948196] Semin Cancer Biol 18(6): 441-50 (2008)

Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine.
[20704751] Cell Div 5(-): 19 (2010)

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy.
[17224055] Cell Div 2(-): 2 (2007)

RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival.
[19660140] Cell Div 4(-): 16 (2009)

Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7.
[19664228] Cell Div 4(-): 17 (2009)

The many faces of ubiquitinated histone H2A: insights from the DUBs.
[18430235] Cell Div 3(-): 8 (2008)

MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity.
[17828282] Cancer Gene Ther 15(1): 1-8 (2008)

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
[20075161] Blood 115(11): 2251-9 (2010)

The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
[17582219] Cell Cycle 6(11): 1319-23 (2007)

Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.
[22455352] Clin Sci (Lond) 123(2): 93-8 (2012)

beta-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.
[20980462] Diabetes 60(1): 227-38 (2011)

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
[17563070] Diabetes 56(9): 2284-94 (2007)

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.
[19712108] FEBS J 276(19): 5381-9 (2009)

Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.
[20843805] J Biol Chem 285(47): 36586-96 (2010)

The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels.
[17110928] EMBO J 25(24): 5659-69 (2006)

E3 ubiquitin ligases as cancer targets and biomarkers.
[16925947] Neoplasia 8(8): 645-54 (2006)

Degradation of activated protein kinases by ubiquitination.
[19489726] Annu Rev Biochem 78(-): 435-75 (2009)

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.
[19489724] Annu Rev Biochem 78(-): 363-97 (2009)

Origin and function of ubiquitin-like proteins.
[19325621] Nature 458(7237): 422-9 (2009)

Strategies for the identification of ubiquitin ligase inhibitors.
[20074047] Biochem Soc Trans 38(Pt 1): 132-6 (2010)

The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
[16689637] Annu Rev Biophys Biomol Struct 35(-): 277-98 (2006)

Biogenesis and function of multivesicular bodies.
[17506697] Annu Rev Cell Dev Biol 23(-): 519-47 (2007)

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications.
[20131003] Apoptosis 15(11): 1292-311 (2010)

Regulation of catalytic activities of HECT ubiquitin ligases.
[17240353] Biochem Biophys Res Commun 354(2): 329-33 (2007)

E3 ubiquitin ligases in ErbB receptor quantity control.
[20868762] Semin Cell Dev Biol 21(9): 936-43 (2010)

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