LE WE PMID CA
Ubiquitin2837Ubiquitin

AIP4

Alcohol

alpha Crystallin

AMP activated protein kinase

BCA2

Bortezomib ttProteasom

BRCA1

Cbl

Cell cylce (BASKET)

Chk1

CRL4Cdt2

CUL4 Cullin4

Cullins

Cyclin D1

DDB1

Diabetes mellitus (Beta cell decay)

DUB

E3 ubiquitin ligase

Endoplasmic reticulum (associated degradation)

ERS UFR (Apoptosis)

ESCRT

Fbw7 Sel10 hCdc4 Ago

FBX4

H2A

HDM2

IAPP islet amyloid polypeptide

Interleukin24 MDA7

Ischemia reperfusion

LUBAC linear ubiquitin chain assembly complex

MARCH protein family

MTOR

Multivesicular bodies

Nedd4 2

Nervous system (Neurodegeneration)

Nervous System (Pathology)

NFKB

p27Kip1

P53

Proteasome (BASKET)

Protein kinase B Akt

Pupylation

PYZD4409 ttUBA1

RBX1

RNF5

SCF (betaTRCP)

SMURF1

SMURF2

Synapse

Synoviolin

TRAF

TRAF2

TRAF3

TRAF6

TRIM32

TRPC4

TRPV4

TRPV6

Ubc3 Cdc34

UbcH10

UbcH7

Ubiquitin

UCH L1

WD40 protein domain

Wnt beta Catenin TCF

XRNF185

2010  
1
Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.
[20109157] Cell Microbiol 12(4): 424-31 (2010)
2009  
2
How microbes utilize host ubiquitination.
[19523153] Cell Microbiol 11(10): 1425-34 (2009)
2007  
3
The enzymes in ubiquitin-like post-translational modifications.
[20103862] Biosci Trends 1(1): 16-25 (2007)
2008  
4
The ubiquitin system, disease, and drug discovery.
[19007437] BMC Biochem 9 Suppl 1(-): S7 (2008)
2008  
5
Deubiquitylating enzymes and disease.
[19007433] BMC Biochem 9 Suppl 1(-): S3 (2008)
2007  
6
Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.
[18047746] BMC Biochem 8 Suppl 1(-): S9 (2007)
2007  
7
Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting.
[18047744] BMC Biochem 8 Suppl 1(-): S7 (2007)
2007  
8
Ubiquitin domain proteins in disease.
[18047733] BMC Biochem 8 Suppl 1(-): S1 (2007)
2005  
9
E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation.
[15882441] Traffic 6(6): 429-41 (2005)
2008  
10
Structures of proteases for ubiqutin and ubiquitin-like modifiers.
[18593526] BMB Rep 41(6): 435-43 (2008)
2006  
11
Role of ubiquitylation in cellular membrane transport.
[16601271] Physiol Rev 86(2): 669-707 (2006)
2002  
12
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
[11917093] Physiol Rev 82(2): 373-428 (2002)
1997  
13
Pathways of ubiquitin conjugation.
[9409544] FASEB J 11(14): 1257-68 (1997)
1997  
14
Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.
[9409543] FASEB J 11(14): 1245-56 (1997)
1997  
15
Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins.
[9409540] FASEB J 11(14): 1215-26 (1997)
2007  
16
Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs.
[17287393] J Cell Sci 120(Pt 4): 543-53 (2007)
2004  
17
2005  
18
Ubiquitylation and cell signaling.
[16148945] EMBO J 24(19): 3353-9 (2005)
1998  
19
The ubiquitin-proteasome pathway: on protein death and cell life.
[9857172] EMBO J 17(24): 7151-60 (1998)
2006  
20
The ubiquitin-proteasome system in cardiac physiology and pathology.
[16501026] Am J Physiol Heart Circ Physiol 291(1): H1-H19 (2006)
2006  
21
Narrative review: protein degradation and human diseases: the ubiquitin connection.
[17088581] Ann Intern Med 145(9): 676-84 (2006)
2008  
22
Protein partners of deubiquitinating enzymes.
[18687060] Biochem J 414(2): 161-75 (2008)
2006  
23
2005  
24
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
[16212556] Biochem J 391(Pt 2): 153-66 (2005)
2004  
25
Getting into position: the catalytic mechanisms of protein ubiquitylation.
[14998368] Biochem J 379(Pt 3): 513-25 (2004)
2005  
26
The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.
[16094395] Cell Death Differ 12(9): 1191-7 (2005)
2005  
27
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
[16094394] Cell Death Differ 12(9): 1178-90 (2005)
2005  
28
Discovery of the ubiquitin proteasome system and its involvement in apoptosis.
[16094390] Cell Death Differ 12(9): 1155-7 (2005)
1999  
29
The role of the ubiquitin-proteasome pathway in apoptosis.
[10381632] Cell Death Differ 6(4): 303-13 (1999)
2008  
30
Cullin-RING ubiquitin ligases: global regulation and activation cycles.
[18282298] Cell Div 3(-): 7 (2008)
2006  
31
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
[16816126] Exp Biol Med (Maywood) 231(7): 1197-211 (2006)
2001  
32
Ubiquitin-mediated degradation of cellular proteins: why destruction is essential for construction, and how it got from the test tube to the patient's bed.
[11411194] Isr Med Assoc J 3(5): 319-27 (2001)
2006  
33
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
[16738015] J Am Soc Nephrol 17(7): 1807-19 (2006)
2003  
34
Non-traditional functions of ubiquitin and ubiquitin-binding proteins.
[12860974] J Biol Chem 278(38): 35857-60 (2003)
2008  
35
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
[18598940] Cancer Cell 14(1): 10-21 (2008)
2005  
36
A genomic and functional inventory of deubiquitinating enzymes.
[16325574] Cell 123(5): 773-86 (2005)
2004  
37
Back to the future with ubiquitin.
[14744430] Cell 116(2): 181-90 (2004)
2000  
38
RING finger proteins: mediators of ubiquitin ligase activity.
[11007473] Cell 102(5): 549-52 (2000)
2007  
39
Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins.
[17643365] Mol Cell 27(2): 174-5 (2007)
2003  
40
Conjugation and deconjugation of ubiquitin regulating the destiny of proteins.
[12642897] Exp Mol Med 35(1): 1-7 (2003)
2010  
41
Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.
[20930542] Cancer Biol Ther 10(8): 737-47 (2010)
2003  
42
Targeting E3 ubiquitin ligases for cancer therapy.
[14688465] Cancer Biol Ther 2(6): 623-9 (2003)
2005  
43
Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor.
[15908780] Cancer Biol Ther 4(5): 506-8 (2005)
2009  
44
The ubiquitin proteasome system in neuropathology.
[19597829] Acta Neuropathol 118(3): 329-47 (2009)
2010  
45
Structural assembly of cullin-RING ubiquitin ligase complexes.
[20880695] Curr Opin Struct Biol 20(6): 714-21 (2010)
2011  
46
Structural regulation of cullin-RING ubiquitin ligase complexes.
[21288713] Curr Opin Struct Biol 21(2): 257-64 (2011)
2007  
47
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.
[17919899] Curr Opin Struct Biol 17(6): 726-35 (2007)
2008  
48
Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease.
[18723090] Biochim Biophys Acta 1782(12): 795-9 (2008)
2008  
49
The ubiquitin-proteasome system in spongiform degenerative disorders.
[18790052] Biochim Biophys Acta 1782(12): 700-12 (2008)
2008  
50
Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.
[18586085] Biochim Biophys Acta 1782(12): 785-94 (2008)
2008  
51
Roles of ubiquitination at the synapse.
[18222124] Biochim Biophys Acta 1779(8): 495-506 (2008)
2010  
52
The various roles of ubiquitin in Wnt pathway regulation.
[20930545] Cell Cycle 9(18): 3700-9 (2010)
2011  
53
CRL4Cdt2: master coordinator of cell cycle progression and genome stability.
[21212733] Cell Cycle 10(2): 241-9 (2011)
2009  
54
Nuclear effects of ethanol-induced proteasome inhibition in liver cells.
[19291815] World J Gastroenterol 15(10): 1163-7 (2009)
2005  
55
2007  
56
Ubiquitin and ubiquitin-like proteins in protein regulation.
[17495234] Circ Res 100(9): 1276-91 (2007)
2010  
57
Ubiquitin, a novel paracrine messenger of cardiac cell survival.
[20100704] Cardiovasc Res 86(1): 1-3 (2010)
2009  
58
Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.
[18684710] J Biol Chem 284(13): 8211-5 (2009)
2008  
59
Polyubiquitin chains: functions, structures, and mechanisms.
[18438605] Cell Mol Life Sci 65(15): 2397-406 (2008)
2009  
60
Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.
[19468686] Cell Mol Life Sci 66(17): 2819-33 (2009)
2011  
61
Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases.
[21710433] Int J Dev Biol 55(3): 249-60 (2011)
2009  
62
Linear polyubiquitination: a new regulator of NF-kappaB activation.
[19543231] EMBO Rep 10(7): 706-13 (2009)
2005  
63
The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling.
[16113643] EMBO Rep 6(9): 815-20 (2005)
2010  
64
The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.
[19940261] FASEB J 24(4): 981-93 (2010)
2010  
65
Roles of E3 ubiquitin ligases in cell adhesion and migration.
[20009572] Cell Adh Migr 4(1): 10-8 (2010)
2009  
66
Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.
[19887490] Clin Cancer Res 15(22): 6751-7 (2009)
2011  
67
E2s: structurally economical and functionally replete.
[21158740] Biochem J 433(1): 31-42 (2011)
2007  
68
Deubiquitinating enzymes as novel anticancer targets.
[17381419] Future Oncol 3(2): 191-9 (2007)
2007  
69
Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms.
[17609522] Mol Interv 7(3): 157-67 (2007)
2009  
70
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.
[19352404] Nat Rev Mol Cell Biol 10(5): 319-31 (2009)
2008  
71
Diversity of degradation signals in the ubiquitin-proteasome system.
[18698327] Nat Rev Mol Cell Biol 9(9): 679-90 (2008)
2009  
72
CRL4s: the CUL4-RING E3 ubiquitin ligases.
[19818632] Trends Biochem Sci 34(11): 562-70 (2009)
2009  
73
Polyubiquitin binding and disassembly by deubiquitinating enzymes.
[19243136] Chem Rev 109(4): 1495-508 (2009)
2009  
74
Ubiquitin in NF-kappaB signaling.
[19281271] Chem Rev 109(4): 1549-60 (2009)
2008  
75
Viral and cellular MARCH ubiquitin ligases and cancer.
[18948196] Semin Cancer Biol 18(6): 441-50 (2008)
2010  
76
Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine.
[20704751] Cell Div 5(-): 19 (2010)
2007  
77
SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy.
[17224055] Cell Div 2(-): 2 (2007)
2009  
78
RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival.
[19660140] Cell Div 4(-): 16 (2009)
2009  
79
Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7.
[19664228] Cell Div 4(-): 17 (2009)
2008  
80
The many faces of ubiquitinated histone H2A: insights from the DUBs.
[18430235] Cell Div 3(-): 8 (2008)
2008  
81
MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity.
[17828282] Cancer Gene Ther 15(1): 1-8 (2008)
2010  
82
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
[20075161] Blood 115(11): 2251-9 (2010)
2007  
83
The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
[17582219] Cell Cycle 6(11): 1319-23 (2007)
2012  
84
Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.
[22455352] Clin Sci (Lond) 123(2): 93-8 (2012)
2011  
85
beta-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.
[20980462] Diabetes 60(1): 227-38 (2011)
2007  
86
Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
[17563070] Diabetes 56(9): 2284-94 (2007)
2009  
87
Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.
[19712108] FEBS J 276(19): 5381-9 (2009)
2010  
88
Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.
[20843805] J Biol Chem 285(47): 36586-96 (2010)
2006  
89
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels.
[17110928] EMBO J 25(24): 5659-69 (2006)
2006  
90
E3 ubiquitin ligases as cancer targets and biomarkers.
[16925947] Neoplasia 8(8): 645-54 (2006)
2009  
91
Degradation of activated protein kinases by ubiquitination.
[19489726] Annu Rev Biochem 78(-): 435-75 (2009)
2009  
92
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.
[19489724] Annu Rev Biochem 78(-): 363-97 (2009)
2009  
93
Origin and function of ubiquitin-like proteins.
[19325621] Nature 458(7237): 422-9 (2009)
2010  
94
Strategies for the identification of ubiquitin ligase inhibitors.
[20074047] Biochem Soc Trans 38(Pt 1): 132-6 (2010)
2006  
95
The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
[16689637] Annu Rev Biophys Biomol Struct 35(-): 277-98 (2006)
2007  
96
Biogenesis and function of multivesicular bodies.
[17506697] Annu Rev Cell Dev Biol 23(-): 519-47 (2007)
2010  
97
Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications.
[20131003] Apoptosis 15(11): 1292-311 (2010)
2007  
98
Regulation of catalytic activities of HECT ubiquitin ligases.
[17240353] Biochem Biophys Res Commun 354(2): 329-33 (2007)
2010  
99
E3 ubiquitin ligases in ErbB receptor quantity control.
[20868762] Semin Cell Dev Biol 21(9): 936-43 (2010)

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  • Ubiquitin

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